RESUMO
Effects produced by different doses of Vit C (2, 3 and 4 gr/day) on lipoprotein and hepatic lipase activities were studied between a group of 35 ambulatory patients, men and women, affected by diabetes mellitus type II with macroangiopathy at lower limbs and/or food. The medium age of patients was 62 years, ranging from 44 to 82 years. Patients were aleatory divided into four groups. One from those four groups was treated with placebo, the other three received Vit C. In the group treated with 3 gr./day of Vit C we found a significant reduction and increase (p less than 0.05) of lipoprotein and hepatic lipase activities, respectively, when we compared outcomes before and after eight weeks of treatment with Vit C. By other hand, when we compared the different groups, we found a significant increase in the hepatic lipase activity in the same group, particularly between the patients whose plasmatic Vit C levels before treatment were reduced. We didn't found any significant change in the rest of parameters.
Assuntos
Ácido Ascórbico/administração & dosagem , Diabetes Mellitus Tipo 2/tratamento farmacológico , Angiopatias Diabéticas/tratamento farmacológico , Lipólise/efeitos dos fármacos , Idoso , Idoso de 80 Anos ou mais , Glicemia/análise , Diabetes Mellitus Tipo 2/sangue , Angiopatias Diabéticas/sangue , Relação Dose-Resposta a Droga , Feminino , Humanos , Masculino , Pessoa de Meia-IdadeRESUMO
In order to evaluate the results of the lumbar sympathectomy, we studied 49 patients in the National Institute of Angiology and Vascular Surgery during two years. The hemodynamic tests were performed the day before and one month after the surgical intervention; they included: skin thermometry, measurement of arterial blood flow and resistance in the foot and in the leg, and reactive hyperemia under photoplethysmographic control. Objectively, it could be seen only an increase in the distal skin temperature and an increase of skin blood flow after this treatment.