RESUMO

Aqueous extract of Bauhinia megalandra leaves was able to inhibit the intestinal glucose absorption in a concentration-dependent way and additive to phlorizine. Moreover, B. megalandra leaf extract drastically reduced the 14C-glucose uptake by enterocyte brush border membrane vesicles. The B. megalandra leaf extract administrated orally, simultaneously with glucose improved the glucose tolerance with a significant reduction of the 30-min peak. The extract did not have an effect on the glucose tolerance when glucose was administrated subcutaneously.

Assuntos

Bauhinia , Glucose/metabolismo , Hipoglicemiantes/farmacologia , Absorção Intestinal/efeitos dos fármacos , Fitoterapia , Extratos Vegetais/farmacologia , Administração Oral , Animais , Radioisótopos de Carbono/metabolismo , Diabetes Mellitus/prevenção & controle , Glucose/administração & dosagem , Teste de Tolerância a Glucose , Hipoglicemiantes/administração & dosagem , Hipoglicemiantes/uso terapêutico , Intestino Delgado/efeitos dos fármacos , Intestino Delgado/metabolismo , Masculino , Microvilosidades/efeitos dos fármacos , Microvilosidades/metabolismo , Extratos Vegetais/administração & dosagem , Extratos Vegetais/uso terapêutico , Folhas de Planta , Ratos , Ratos Sprague-Dawley