RESUMO
BACKGROUND: It has been found that the cholesterol and triglyceride values are higher in preeclampsia than in normal pregnancy, even though it is unclear whether these levels are related to the severity. The aim of this study was to determine the correlation between dyslipidemia and severity in preeclampsia. METHODS: Comparative cross-sectional study in 200 patients, 100 with normal pregnancy and 100 with preeclampsia. The age, gynecological and obstetric history, total cholesterol and triglycerides were identified. Descriptive statistics were used: Student's t test for comparing the group of patients with preeclampsia and normal pregnancies, and ANOVA and odds ratio for the subanalysis of mild and severe preeclampsia. RESULTS: No statistically significant differences in age or cholesterol were found. Triglycerides showed a statistically significant difference: they were higher in relation to the severity of preeclampsia (normal pregnancy: 245 mg; mild preeclampsia: 308 mg; severe preeclampsia: 349 mg). CONCLUSIONS: Elevated levels of cholesterol and triglycerides in patients with preeclampsia showed no consistent relationship with the severity of preeclampsia.
Introducción: se ha identificado que los valores del colesterol y los triglicéridos (TG) son más altos en la preeclampsia que en el embarazo normal; sin embargo, aún no está claro si estos niveles tienen relación con la gravedad del proceso. El objetivo del estudio fue determinar si existe relación entre la dislipidemia y la gravedad en la preeclampsia. Métodos: estudio transversal comparativo en 200 pacientes, 100 con embarazo normal y 100 con preeclampsia. Se identificó edad, antecedentes ginecoobstétricos, colesterol total y TG. Se utilizó estadística descriptiva: t de Student para comparar el grupo de pacientes con preeclampsia y embarazos normales, y ANOVA y razón de momios para el subanálisis de preeclampsia leve y severa. Resultados: no se encontraron diferencias estadísticamente significativas en edad, ni en colesterol. Los TG presentaron una diferencia estadísticamente significativa: fueron más altos en relación con la gravedad de la preeclampsia (embarazo normal 245 mg, preeclampsia leve 308 mg y preeclampsia severa 349 mg). Conclusión: los niveles elevados de colesterol y TG en pacientes con preeclampsia no demostraron consistencia en relación con la gravedad de la preeclampsia.
Assuntos
Dislipidemias/complicações , Pré-Eclâmpsia , Adulto , Colesterol/sangue , Estudos Transversais , Dislipidemias/sangue , Feminino , Humanos , Pré-Eclâmpsia/sangue , Gravidez , Índice de Gravidade de Doença , Triglicerídeos/sangueRESUMO
Endothelial dysfunction is a fundamental characteristic in the physiopathology of preeclampsia. Currently, a series of markers which explain endothelial dysfunction have been identified. The recognition of endothelial dysfunction has been used to realize an early diagnosis of preeclampsia, as soon as the classification of a possible prognosis. Nevertheless the detection of these markers is not accessible to the majority of hospitable centers that treat patients with preeclampsia. One indirect marker of endothelial dysfunction with a greater accessibility is the assessment of peripheral blood smear. Several studies had proved the presence of endothelial dysfunction by identification of red blood cells crenated in peripheral blood smear led us also to measure the impact in the evolution of the disease.