RESUMO
INTRODUCTION: in the treatment the long head of the biceps tendon (LHBT) pathology, the «relaxed tenodesis¼ is an arthroscopic articular suprapectoral tenodesis that seeks to lower the tension on the LHBT, and therefore, theoretically avoid persistent pain. OBJECTIVE: to assess clinical and radiological results of «relaxed¼ tenodesis in a prospective cohort of patient with work related illness. MATERIAL AND METHODS: prospective cohort, 54 shoulders with «relaxed¼ tenodesis performed with an intra-articular interference screw by the same surgeon, from October 2014 to 2018, in a level 1 trauma center. Demographic, clinical, functional and radiologic results were analyzed. On 6 months follow-up, a sonographic and clinical assessment was performed. RESULTS: mean age 49 ± 9, mean follow-up 16 ± 4 months. The main diagnosis was a rotator cuff tear in 79%, primary biceps pathology in 10% and other pathologies in 11%. At the end of follow-up, the cohort showed active anterior elevation 157.7 ± 22.7, external rotation 47 ± 16.6, median internal rotation T12, Constant Score 83 ± 12.05 points, subjective shoulder value 83 ± 12.97% and pain visual analogue scale 1.4 ± 1.7 points. One patient had a biceps tear and two had cosmetic arm asymmetry. On ultrasound 98% had the LHBT in situ and 10% had inflammatory changes on the bicipital groove. There were complications in 21% of the sample. CONCLUSIONS: «relaxed biceps tenodesis¼ is a technique that shows good clinical, functional and sonographic results, with low failure rate.
INTRODUCCIÓN: en el tratamiento de la patología del tendón de la cabeza larga del bíceps (TCLB) la tenodesis «relajada¼ es una tenodesis artroscópica suprapectoral alta, que busca disminuir la tensión del TCLB y, por tanto, el dolor persistente. OBJETIVO: evaluar resultados clínicos y radiológicos de la tenodesis «relajada¼ en una serie prospectiva de sujetos sometidos a compensación laboral. MATERIAL Y MÉTODOS: cohorte prospectiva de 54 hombros con tenodesis «relajada¼ con tornillo interferencial intraarticular, mismo cirujano, Octubre de 2014 a 2018, centro de trauma nivel 1. Se analizaron datos demográficos, resultados clínicos, funcionales y radiográficos. A los seis meses se realizó una ecografía de control y se evaluaron complicaciones. RESULTADOS: edad media 49 ± 9 años, seguimiento promedio 16 ± 4 meses. El diagnóstico primario fue rotura del manguito rotador en 79%, patología primaria del bíceps en 10% y otras patologías en 11%. Al término del seguimiento, la elevación anterior activa fue 157.7 ± 22.7, rotación externa 47 ± 16.6, rotación interna mediana T12, Constant Score 83 ± 12.05 puntos, valoración subjetiva del hombro 83 ± 12.97% y escala visual análoga del dolor 1.4 ± 1.7 puntos. Un paciente sufrió una rotura del bíceps y dos casos una asimetría estética del brazo. En ecografía, en 98% se visualizó el TCLB in situ y en 10% se objetivaron cambios inflamatorios en la corredera bicipital. Reportamos 21% de complicaciones. CONCLUSIONES: la tenodesis «relajada¼ presenta resultados clínicos, funcionales e imagenológicos satisfactorios, con baja tasa de fallo.
Assuntos
Lesões do Manguito Rotador , Tenodese , Humanos , Adulto , Pessoa de Meia-Idade , Tenodese/métodos , Braço/cirurgia , Estudos Prospectivos , Artroscopia , Lesões do Manguito Rotador/cirurgia , DorRESUMO
PURPOSE: Compare functional and radiological outcomes of three different designs of reverse shoulder arthroplasty according to distalization and lateralization shoulder angle, in heterogenic diagnostics (fracture, cuff arthropathy, fracture sequela and osteoarthritis). MATERIAL AND METHODS: Prospective cohort of 33 patients of reverse shoulder arthroplasty (RSA) between December 2014 and July 2017 with a minimum one year of follow-up. We defined three groups, G: 10 patients with Grammont (155o, Medialized Glena), B: 9 patients with Bio-RSA (155º, lateralized bone glena) and A: 14 patients with Arrow (135o, lateralized metallic glena). We analyze demographic, clinical, functional and radiological outcomes (lateralization shoulder angle (LSA) and distalization shoulder angle (DSA)). For the statistical analysis, ANOVA, T-tests and linear regression tests were used, with a statistical significance of 5%. RESULTS: The LSA was significantly higher in group A (98o A, 79o G, 80o B) (p < 0.05). In DSA, group B was significantly higher than A (52o B, 39o A) (p < 0.05) and not significant to G (48o G) (p = 0.06). There was no correlation of LSA and DSA with external rotation (p = 0.51) and active elevation (p = 0.41), respectively. There was no significant clinical (anterior elevation, external rotation, internal rotation) and functional outcomes (adjusted Constant score and subjective shoulder evaluation) differences between the different RSA models (p > 0.05). CONCLUSIONS: The LSA was higher in the Arrow and the DSA was higher in Bio-RSA. We did not find Clinical - Radiological correlation in this heterogeneous series of patients.
OBJETIVO: Comparar resultados funcionales e imagenológicos de tres modelos protésicos según el índice de lateralización y distalización. En un grupo heterogéneo de diagnósticos (fractura, artropatía de manguito, secuela de fractura y artrosis glenohumeral). MATERIAL Y MÉTODOS: Cohorte prospectiva de 33 pacientes sometidos a prótesis reversa de hombro entre Diciembre 2014 y Julio 2017 con un seguimiento mínimo de un año. Se definieron tres grupos, G: 10 pacientes con Grammont clásico (155o, Glena medializada); B: nueve pacientes con Bio-RSA (155o, glena lateralizada ósea); y A: 14 con Arrow (135o, glena lateralizada metálica). Las variables fueron: datos demográficos, clínicos, funcionales y radiológicos (ángulo de lateralización y distalización). Para el análisis estadístico se utilizaron pruebas de ANOVA, T-test y regresión lineal, con una significancia estadística de 5%. RESULTADOS: El ángulo de lateralización del hombro (LSA) fue significativamente mayor en el grupo A (98o A, 79o G, 80o B) (p < 0.05). El ángulo de distalización del hombro (DSA) del grupo B fue significativamente superior al A (52o B, 39o A) (p < 0.05) y no significativamente superior al G (48o G) (p = 0.06). No se demostró una correlación entre el LSA y DSA con la rotación externa (p = 0.51) y elevación activa (p = 0.41), respectivamente. En índices clínicos (elevación anterior, rotación externa, rotación interna) y funcionales (índice Constant ajustado y evaluación subjetiva de hombro) no encontramos diferencias significativas entre los distintos modelos protésicos (p > 0.05). CONCLUSIONES: El ángulo de lateralización fue mayor en el modelo Arrow y distalización en el modelo Bio-RSA. No encontramos correlación clínica-radiológica en esta serie heterogénea de pacientes.
Assuntos
Prótese de Ombro , Humanos , Estudos ProspectivosRESUMO
Resumen: Objetivo: Comparar resultados funcionales e imagenológicos de tres modelos protésicos según el índice de lateralización y distalización. En un grupo heterogéneo de diagnósticos (fractura, artropatía de manguito, secuela de fractura y artrosis glenohumeral). Material y métodos: Cohorte prospectiva de 33 pacientes sometidos a prótesis reversa de hombro entre Diciembre 2014 y Julio 2017 con un seguimiento mínimo de un año. Se definieron tres grupos, G: 10 pacientes con Grammont clásico (155o, Glena medializada); B: nueve pacientes con Bio-RSA (155o, glena lateralizada ósea); y A: 14 con Arrow (135o, glena lateralizada metálica). Las variables fueron: datos demográficos, clínicos, funcionales y radiológicos (ángulo de lateralización y distalización). Para el análisis estadístico se utilizaron pruebas de ANOVA, T-test y regresión lineal, con una significancia estadística de 5%. Resultados: El ángulo de lateralización del hombro (LSA) fue significativamente mayor en el grupo A (98o A, 79o G, 80o B) (p < 0.05). El ángulo de distalización del hombro (DSA) del grupo B fue significativamente superior al A (52o B, 39o A) (p < 0.05) y no significativamente superior al G (48o G) (p = 0.06). No se demostró una correlación entre el LSA y DSA con la rotación externa (p = 0.51) y elevación activa (p = 0.41), respectivamente. En índices clínicos (elevación anterior, rotación externa, rotación interna) y funcionales (índice Constant ajustado y evaluación subjetiva de hombro) no encontramos diferencias significativas entre los distintos modelos protésicos (p > 0.05). Conclusiones: El ángulo de lateralización fue mayor en el modelo Arrow y distalización en el modelo Bio-RSA. No encontramos correlación clínica-radiológica en esta serie heterogénea de pacientes.
Abstract: Purpose: Compare functional and radiological outcomes of three different designs of reverse shoulder arthroplasty according to distalization and lateralization shoulder angle, in heterogenic diagnostics (fracture, cuff arthropathy, fracture sequela and osteoarthritis). Material and methods: Prospective cohort of 33 patients of reverse shoulder arthroplasty (RSA) between December 2014 and July 2017 with a minimum one year of follow-up. We defined three groups, G: 10 patients with Grammont (155o, Medialized Glena), B: 9 patients with Bio-RSA (155º, lateralized bone glena) and A: 14 patients with Arrow (135o, lateralized metallic glena). We analyze demographic, clinical, functional and radiological outcomes (lateralization shoulder angle (LSA) and distalization shoulder angle (DSA)). For the statistical analysis, ANOVA, T-tests and linear regression tests were used, with a statistical significance of 5%. Results: The LSA was significantly higher in group A (98o A, 79o G, 80o B) (p < 0.05). In DSA, group B was significantly higher than A (52o B, 39o A) (p < 0.05) and not significant to G (48o G) (p = 0.06). There was no correlation of LSA and DSA with external rotation (p = 0.51) and active elevation (p = 0.41), respectively. There was no significant clinical (anterior elevation, external rotation, internal rotation) and functional outcomes (adjusted Constant score and subjective shoulder evaluation) differences between the different RSA models (p > 0.05). Conclusions: The LSA was higher in the Arrow and the DSA was higher in Bio-RSA. We did not find Clinical - Radiological correlation in this heterogeneous series of patients.
RESUMO
PURPOSE: Baseline LDH, derived neutrophil-lymphocyte ratio (dNLR) and immune-related adverse events (irAEs) are associated with outcomes of patients with metastatic melanoma (MM). We hypothesized whether dynamic shifts in LDH, dNLR and incidence of irAEs may impact the prognosis of MM patients treated with anti-CTLA4 or anti-PD1 as single agents. METHODS: Retrospective analysis of medical charts from MM patients with prospective monitoring of dNLR, LDH values and irAE incidence. Primary endpoint was overall survival (OS). RESULTS: Patients switching from either high dNLR (≥2.5) to low dNLR (HR: 0.14; 0.03-0.74; p = 0.02) or high LDH (≥1.5 × ULN) to low LDH levels (HR: 0.08; 0.01-0.68; p = 0.02) had significantly better OS than those with high dNLR or LDH scores at the end of cycle 2. Longer OS was also observed in patients developing irAEs ≥ grade 2 as compared to no irAEs (HR: 0.2; 0.05-0.89; p = 0.03). CONCLUSIONS: We found that major shifts in dNLR and LDH measures from baseline to cycle 2 measures and shifts from baseline to cycle 2 are significantly associated with OS in MM patients receiving single agent anti-PD1 therapy. Laboratory changes and clinical variables may help optimize prognostic estimates.
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Biomarcadores Tumorais/sangue , Imunoterapia , Lactato Desidrogenases/sangue , Linfócitos/citologia , Melanoma/mortalidade , Neutrófilos/citologia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Anticorpos Monoclonais Humanizados/uso terapêutico , Feminino , Humanos , Inibidores de Checkpoint Imunológico/uso terapêutico , Imunoterapia/efeitos adversos , Ipilimumab/uso terapêutico , Masculino , Melanoma/sangue , Melanoma/secundário , Melanoma/terapia , Pessoa de Meia-Idade , Nivolumabe/uso terapêutico , Estudos Prospectivos , Estudos Retrospectivos , Resultado do Tratamento , Adulto JovemRESUMO
Brachial plexus lesions can significantly affect patient function. The type of management will depend on the severity of the injury as well as the anatomical location. Tendon transfers around the shoulder have emerged as an effective treatment alternative, and therefore we should consider them when faced with patients who might require it. There are various transfer techniques, within which the most frequently used are upper trapezium, latissimus dorsi and lower trapezium transfers, each with its specific indications and objectives depending on the type of patient. These surgeries aim to decrease the pain resulting from the hypotonia and glenohumeral subluxation as well as improve the range of movement of the shoulder, getting the patient to take his hand to the plane that requires to perform his daily life activities. We will provide a description of some of the most commonly used shoulder tendon transfer techniques associated with a bibliographic review and a description of our experience with these surgeries.
Las lesiones de plexo braquial pueden afectar de forma muy significativa la función de los pacientes. El tipo de manejo va a depender de la severidad de la lesión como también de la localización anatómica de ésta. Las transferencias tendíneas alrededor del hombro han surgido como una alternativa efectiva de tratamiento y por lo tanto, debemos considerarlas cuando nos vemos enfrentados a pacientes que la podrían requerir. Existen diversas técnicas de transferencia, las que se utilizan con más frecuencia son las transferencias de trapecio superior, de dorsal ancho y de trapecio inferior, cada una con sus indicaciones y objetivos específicos según el tipo de paciente. Estas cirugías tienen como propósito disminuir el dolor producto de la hipotonía y subluxación glenohumeral como también mejorar el rango de movimiento del hombro, logrando que el paciente lleve su mano al plano que requiera para realizar sus actividades de la vida diaria. Presentaremos algunas de las técnicas de transferencia tendínea de hombro más utilizadas asociadas a una revisión bibliográfica y una descripción de nuestra experiencia con estas cirugías.
Assuntos
Traumatismos do Nascimento , Neuropatias do Plexo Braquial , Plexo Braquial , Articulação do Ombro , Plexo Braquial/lesões , Plexo Braquial/cirurgia , Neuropatias do Plexo Braquial/etiologia , Neuropatias do Plexo Braquial/cirurgia , Humanos , Amplitude de Movimento Articular , Ombro , Transferência Tendinosa , Resultado do TratamentoRESUMO
PURPOSE: The Spanish Society of Medical Oncology (SEOM) has carried out a study to analyse the conditions of access to oncology drugs in clinical practice in Spain. For the first time, the access of predictive biomarkers has also been analyzed. METHODS: A questionnaire was sent to 146 hospitals in Spain to collect information on the process of approval of 11 oncology drugs of an unquestionable clinical benefit and five predictive biomarkers of mandatory determination for specific treatments. RESULTS: Results highlight the still existing differences in the access of oncology drugs, as well as the newly identified differences in the access to predictive biomarkers between Autonomous Communities (AACC) in Spain, as well as between different hospitals within the same Autonomous Community. Conclusions The SEOM considers it necessary to reduce the differences identified, increase homogeneity, and improve conditions of access to oncology drugs and biomarkers, and makes proposals to address these issues.
Assuntos
Antineoplásicos/provisão & distribuição , Biomarcadores Tumorais/análise , Aprovação de Drogas , Oncologia , Sociedades Médicas , Tomada de Decisão Clínica , Humanos , Neoplasias/tratamento farmacológico , Neoplasias/mortalidade , Espanha , Inquéritos e Questionários , Fatores de TempoRESUMO
Resumen: Las lesiones de plexo braquial pueden afectar de forma muy significativa la función de los pacientes. El tipo de manejo va a depender de la severidad de la lesión como también de la localización anatómica de ésta. Las transferencias tendíneas alrededor del hombro han surgido como una alternativa efectiva de tratamiento y por lo tanto, debemos considerarlas cuando nos vemos enfrentados a pacientes que la podrían requerir. Existen diversas técnicas de transferencia, las que se utilizan con más frecuencia son las transferencias de trapecio superior, de dorsal ancho y de trapecio inferior, cada una con sus indicaciones y objetivos específicos según el tipo de paciente. Estas cirugías tienen como propósito disminuir el dolor producto de la hipotonía y subluxación glenohumeral como también mejorar el rango de movimiento del hombro, logrando que el paciente lleve su mano al plano que requiera para realizar sus actividades de la vida diaria. Presentaremos algunas de las técnicas de transferencia tendínea de hombro más utilizadas asociadas a una revisión bibliográfica y una descripción de nuestra experiencia con estas cirugías.
Abstract: Brachial plexus lesions can significantly affect patient function. The type of management will depend on the severity of the injury as well as the anatomical location. Tendon transfers around the shoulder have emerged as an effective treatment alternative, and therefore we should consider them when faced with patients who might require it. There are various transfer techniques, within which the most frequently used are upper trapezium, latissimus dorsi and lower trapezium transfers, each with its specific indications and objectives depending on the type of patient. These surgeries aim to decrease the pain resulting from the hypotonia and glenohumeral subluxation as well as improve the range of movement of the shoulder, getting the patient to take his hand to the plane that requires to perform his daily life activities. We will provide a description of some of the most commonly used shoulder tendon transfer techniques associated with a bibliographic review and a description of our experience with these surgeries.
Assuntos
Humanos , Articulação do Ombro , Traumatismos do Nascimento , Plexo Braquial/cirurgia , Plexo Braquial/lesões , Neuropatias do Plexo Braquial/cirurgia , Neuropatias do Plexo Braquial/etiologia , Ombro , Transferência Tendinosa , Amplitude de Movimento Articular , Resultado do TratamentoRESUMO
BACKGROUND: Hantavirus cardiopulmonary syndrome (HCPS) is caused by new world hantaviruses, among which Andes hantavirus (ANDV) is endemic to Chile and Southern Argentina. The disease caused by ANDV produces plasma leakage leading to enhanced vascular permeability and has a high case fatality rate (35%), mainly due to respiratory failure, pulmonary edema and myocardial dysfunction, hypoperfusion and shock. Host sociodemographic and genetic factors might influence the course and outcome of the disease. Yet, they have not been thoroughly characterized. AIM: To evaluate sociodemographic factors as risk factors in severity of HCPS. PATIENTS AND METHODS: Study period: 2004-20013, attending in eight collaborative centers, etiological diagnosis was performed by serology or molecular biology, mild and severe HCPS were compared.139 Chilean patients were analyzed, 64 (46%) with severe disease among which 12 (19 %) died. RESULTS: European ethnicity had 5,1 times higher risk than Amerindian ethnic group to develop a severe HCPS, greater seriousness that was also associated with an urban residence. CONCLUSION: It was observed that ethnicity and type of residence were significant risk factors for HCPS severity. Hypotheses explaining these findings are discussed.
Assuntos
Síndrome Pulmonar por Hantavirus/mortalidade , Adolescente , Adulto , Idoso , Criança , Chile/epidemiologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Fatores de Risco , Índice de Gravidade de Doença , Fatores Socioeconômicos , Adulto JovemRESUMO
Resumen Introducción: El síndrome cardiopulmonar por hantavirus (SCPH) es causado en Chile y en el sur de Argentina por el Andes hantavirus (ANDV), el que es endémico en esta zona. La enfermedad causada por ANDV produce un aumento de permeabilidad vascular y filtración de plasma con una alta tasa de letalidad (35%), debido principalmente a insuficiencia respiratoria por edema pulmonar y al desarrollo en los casos graves de compromiso miocárdico, hipoperfusión y shock. Aunque se sabe que los factores socio-demográficos del hospedero pueden influir en el curso y el resultado de la enfermedad, estos no se han caracterizado previamente en la población chilena. Objetivo: Evaluar la relación entre los factores socio-demográficos y la gravedad del SCPH. Pacientes y Métodos: Período de análisis 2004-20013, pacientes atendidos en ocho centros colaboradores, diagnóstico etiológico serológico o por biología molecular, se comparan SCPH leve y grave. Se analizaron 139 pacientes chilenos, 64 (46%) con enfermedad grave, entre los cuales 12 murieron (19%). Resultados: La etnia europea tuvo un riesgo 5,1 veces mayor de desarrollar un SCPH grave que la etnia amerindia, gravedad mayor que también se asoció a una residencia urbana. Conclusiones: Se observó una asociación estadísticamente significativa entre etnia, lugar de residencia y evolución de SCPH. Se discuten hipótesis que expliquen estos hallazgos.
Background: Hantavirus cardiopulmonary syndrome (HCPS) is caused by new world hantaviruses, among which Andes hantavirus (ANDV) is endemic to Chile and Southern Argentina. The disease caused by ANDV produces plasma leakage leading to enhanced vascular permeability and has a high case fatality rate (35%), mainly due to respiratory failure, pulmonary edema and myocardial dysfunction, hypoperfusion and shock. Host sociodemographic and genetic factors might influence the course and outcome of the disease. Yet, they have not been thoroughly characterized. Aim: To evaluate sociodemographic factors as risk factors in severity of HCPS. Patients and Methods: Study period: 2004-20013, attending in eight collaborative centers, etiological diagnosis was performed by serology or molecular biology, mild and severe HCPS were compared.139 Chilean patients were analyzed, 64 (46%) with severe disease among which 12 (19 %) died. Results: European ethnicity had 5,1 times higher risk than Amerindian ethnic group to develop a severe HCPS, greater seriousness that was also associated with an urban residence. Conclusion: It was observed that ethnicity and type of residence were significant risk factors for HCPS severity. Hypotheses explaining these findings are discussed.
Assuntos
Humanos , Masculino , Feminino , Criança , Adolescente , Adulto , Pessoa de Meia-Idade , Idoso , Adulto Jovem , Síndrome Pulmonar por Hantavirus/mortalidade , Fatores Socioeconômicos , Índice de Gravidade de Doença , Chile/epidemiologia , Fatores de RiscoRESUMO
RESUMEN Introducción: La disfunción eréctil es una patología que afecta, en torno al 20 por ciento de la población masculina que ocasiona un importante deterioro en su calidad de vida. La DE moderada, completa aumenta en relación a la edad. La población en Chile está envejeciendo y su vida sexual se puede ver afectada. El implante de una prótesis de pene maleable es la alternativa cuando los tratamientos médicos no cumplen las expectativas del paciente. Objetivo: Evaluar el grado de satisfacción de los pacientes usuarios de prótesis de pene maleable como tratamiento de Disfunción Eréctil. Pacientes y métodos: Estudio retrospectivo analítico mediante recopilación de historias clínicas de pacientes con disfunción eréctil usuarios de prótesis de pene maleable en el HCVB en el lapso de tiempo comprendido entre mayo 2014 y julio 2017. La satisfacción del tratamiento se valoró empleando una entrevista personal, utilizando el cuestionario EDITS. Resultados: Se encuestaron a 32 pacientes usuarios de prótesis de pene maleable. La media de edad para el uso de prótesis fué de 64,5 (48 81) años. Según la escala de satisfacción EDITS el uso de las prótesis de pene 84,9 por ciento de los pacientes se encuentran satisfechos con el uso de este tratamiento. 87 por ciento de satisfacción en relación al cumplimiento de las expectativas. La maniobrabilidad y la técnica de uso una satisfacción del 90 por ciento. El 81 por ciento desea continuar usando la prótesis. El 90 por ciento de los pacientes se sienten con mayor confianza al mantener sus relaciones sexuales. El 84 por ciento de las parejas se encuentras satisfechas con el tratamiento de su pareja. Conclusión: La experiencia de nuestro servicio muestra resultados elevados de satisfacción en el uso de prótesis de pene maleables tanto para el paciente como para su pareja en el tratamiento de la disfunción eréctil. Estos resultados nos alientan a seguir con el tratamiento con prótesis maleable para pacientes beneficiarios de nuestro sistema público de salud.(AU)
ABSTRACT Introduction: Erectile dysfunction is a pathology affecting about 20 pertcent of the male population that causes a significant deterioration in their quality of life. Moderate, complete ED increases with age. The population in Chile is aging and their sex life may be affected. The implantation of a malleable penile prosthesis is the alternative when the medical treatments do not meet the expectations of the patient. Objective: To evaluate the degree of satisfaction of patients with malleable penile prosthesis as a treatment for Erectile Dysfunction. Patients and Methods: An analytical retrospective study by means of the compilation of clinical records of patients with erectile dysfunction users of malleable penile prostheses in the HCVB in the time span between May 2014 and July 2017. The satisfaction of the treatment was assessed using a personal interview, using the EDITS questionnaire. Results: We surveyed 32 patients with malleable penile prosthesis. The mean age for prosthesis use was 64.5 (48 81) years. According to the EDITS satisfaction scale the use of penile prostheses 84.9 pertcent of patients are satisfied with the use of this treatment. 87 pertcent satisfaction in relation to the fulfillment of expectations. The maneuverability and the technique of use a satisfaction of 90 pertcent. 81pertcent want to continue using the prosthesis. 90 pertcent of patients feel more confident about having sex. 84 pertcent of couples are satisfied with their partner's treatment. Conclusion: The experience of our service shows high satisfaction results in the use of malleable prostheses for both the patient and his partner in the treatment of erectile dysfunction. These results encourage us to continue with the treatment with malleable prosthesis for patients who are beneficiaries of our public health system.(AU)
Assuntos
Masculino , Satisfação Pessoal , Prótese de Pênis , Disfunção ErétilRESUMO
Postoperative pain and inflammation after oral surgery is mostly managed using non-steroidal anti-inflammatory drugs (NSAIDs). However, opioids combined with NSAIDs may improve pain management in patients, especially after traumatic oral surgery. Few studies have compared NSAIDs with and without opioid use after oral and maxillofacial surgery. This randomized, double-blind, cross-over study compared the clinical efficacy of either diclofenac (50mg) and codeine (50mg) or diclofenac alone (50mg) for the management of postoperative pain after invasive third molar surgery. Volunteers (n=46) who were scheduled to undergo the removal of symmetrically positioned lower third molars in two separate appointments were included. They reported significantly less postoperative pain at various time points within 24h after surgery and also consumed significantly less rescue medication (paracetamol (acetaminophen)) throughout the study when they took diclofenac combined with codeine than when they took only diclofenac. In conclusion, oral diclofenac with codeine was more effective for managing postoperative pain than diclofenac without codeine. It was expected that patients taking two pain medications after surgery would generally have less pain than when taking only one of the two medications. The prospective cross-over design of the present work makes this study distinct from many others.
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Analgésicos Opioides/uso terapêutico , Anti-Inflamatórios não Esteroides/uso terapêutico , Codeína/uso terapêutico , Diclofenaco/uso terapêutico , Dente Serotino/cirurgia , Dor Pós-Operatória/tratamento farmacológico , Dente Impactado/cirurgia , Administração Oral , Analgésicos Opioides/administração & dosagem , Anti-Inflamatórios não Esteroides/administração & dosagem , Codeína/administração & dosagem , Estudos Cross-Over , Diclofenaco/administração & dosagem , Método Duplo-Cego , Quimioterapia Combinada , Feminino , Humanos , Masculino , Manejo da Dor , Medição da Dor , Extração Dentária , Resultado do Tratamento , Adulto JovemRESUMO
Resumen: Objetivo: La técnica a través del abordaje del seno del tarso (AST), se ha convertido en una opción cada vez más popular para el tratamiento de las fracturas de calcáneo. A pesar de los buenos resultados reportados, las complicaciones relacionadas con la fijación interna no han sido analizadas aún. A través de mediciones en tomografías computadas con reconstrucción 3D (TC) hemos planteado el objetivo de realizar una descripción del calcáneo aplicada al uso de osteosíntesis en fracturas de dicho hueso. Métodos: Se obtuvieron, retrospectivamente, 24 estudios de TC de 22 pacientes consecutivos que presentaban calcáneos sanos sin antecedente de cirugía ni fractura, 18 hombres y cuatro mujeres, 14 derechos y 10 izquierdos. La edad promedio fue de 45.8 (rango: 19-79) años. Se realizaron mediciones del ancho y largo de tornillos que se necesitarían para fijar una fractura de calcáneo con un montaje predefinido. Resultados: Los resultados están enfocados en mediciones obtenidas de imágenes de TC, las cuales ayudarían al cirujano a un correcto posicionamiento, angulación y largo de los tornillos necesarios para la fijación interna de fracturas de calcáneo. Conclusión: Este estudio describe una serie de mediciones del calcáneo que resultan de utilidad para la fijación interna de fracturas de calcáneo a través del AST. Su propósito es minimizar las complicaciones derivadas del uso de osteosíntesis en estas fracturas.
Abstract: Objective: The mini-invasive technique, through a sinus tarsi approach (STA), has become an increasingly popular choice for the treatment of calcaneal fractures. However, despite the good results reported, the complications related with internal fixation have not yet been analyzed. Using 3D reconstruction CT scans, we proposed doing biometric description of the calcaneus with the purpose of performing osteosynthesis as treatment for calcaneal fractures. Methods: A total of 24 CT scans were retrospectively obtained from 22 consecutive patients with healthy calcanei and no history of surgery or fracture. They included 18 males and 4 females; 14 right and 10 left calcanei. Mean age was 45.8 (range 19-79). The width and length of the screws needed to fix a calcaneal fracture with a predefined montage were measured. Results: The results focus on biometric measurements obtained from CT scans that may help surgeons achieve proper positioning, angulation and length of the screws needed for the internal fixation of calcaneal fractures. Conclusion: This study describes a series of biometric calcaneal measurements that are useful for the internal fixation of calcaneal fractures using a sinus tarsi approach. The purpose is to minimize the complications resulting from osteosynthesis to treat these fractures.
Assuntos
Humanos , Masculino , Feminino , Adulto , Idoso , Calcâneo/lesões , Calcâneo/diagnóstico por imagem , Fraturas Ósseas/cirurgia , Fraturas Ósseas/diagnóstico por imagem , Fixação Interna de Fraturas , Placas Ósseas , Calcanhar , Resultado do Tratamento , Pessoa de Meia-IdadeRESUMO
OBJECTIVE: The mini-invasive technique, through a sinus tarsi approach (STA), has become an increasingly popular choice for the treatment of calcaneal fractures. However, despite the good results reported, the complications related with internal fixation have not yet been analyzed. Using 3D reconstruction CT scans, we proposed doing biometric description of the calcaneus with the purpose of performing osteosynthesis as treatment for calcaneal fractures. METHODS: A total of 24 CT scans were retrospectively obtained from 22 consecutive patients with healthy calcanei and no history of surgery or fracture. They included 18 males and 4 females; 14 right and 10 left calcanei. Mean age was 45.8 (range 19-79). The width and length of the screws needed to fix a calcaneal fracture with a predefined montage were measured. RESULTS: The results focus on biometric measurements obtained from CT scans that may help surgeons achieve proper positioning, angulation and length of the screws needed for the internal fixation of calcaneal fractures. CONCLUSION: This study describes a series of biometric calcaneal measurements that are useful for the internal fixation of calcaneal fractures using a sinus tarsi approach. The purpose is to minimize the complications resulting from osteosynthesis to treat these fractures.
La técnica a través del abordaje del seno del tarso (AST), se ha convertido en una opción cada vez más popular para el tratamiento de las fracturas de calcáneo. A pesar de los buenos resultados reportados, las complicaciones relacionadas con la fijación interna no han sido analizadas aún. A través de mediciones en tomografías computadas con reconstrucción 3D (TC) hemos planteado el objetivo de realizar una descripción del calcáneo aplicada al uso de osteosíntesis en fracturas de dicho hueso.
Assuntos
Calcâneo , Fixação Interna de Fraturas , Fraturas Ósseas , Adulto , Idoso , Placas Ósseas , Calcâneo/diagnóstico por imagem , Calcâneo/lesões , Feminino , Fraturas Ósseas/diagnóstico por imagem , Fraturas Ósseas/cirurgia , Calcanhar , Humanos , Masculino , Pessoa de Meia-Idade , Resultado do TratamentoRESUMO
This double-blind crossover randomized clinical trial compared the efficacy of 2 concentrations of articaine, 2% (A2) and 4% (A4), with 1:200,000 epinephrine, for lower third molar removal. During 2 separate appointments with either A2 or A4, both similarly positioned lower third molars in 46 volunteers were extracted. The following were evaluated: onset and duration of anesthetic action on soft tissues, intraoperative bleeding, hemodynamic parameters, postoperative analgesia, and mouth opening and wound healing during the 7th postoperative day, along with the incidence, type, and severity of adverse reactions. Nearly identical volumes of both anesthetic solutions were used for each appointment: 3.4 ± 0.9 mL ≈ 68 mg of articaine (A2) and 3.3 ± 0.8 mL ≈ 132 mg of articaine (A4). Statistical analysis indicated no differences in onset or duration of anesthetic action on soft tissues or duration of postoperative analgesia evoked by A2 and A4 anesthetic solutions (P > 0.05). The surgeon's rating of intraoperative bleeding was considered minimal throughout all surgery with both anesthetic solutions. While transient changes in blood pressure, heart rate, and oxygen saturation were observed, these factors were clinically insignificant and were uninfluenced by articaine concentration (P > 0.05). No systemic or local adverse reactions were observed in the preoperative and postoperative periods due to A2 or A4, but 1 case of bilateral paresthesia was observed. There were no significant differences between preoperative and postoperative (7th day) values of mouth opening and wound healing whether volunteers received A2 or A4 (P > 0.05). In conclusion, both A2 and A4, administered in equal volumes, were effective and safe during lower third molar surgery, and no significant differences were found between their efficacy and safety (ClinicalTrials.gov NCT02457325).
Assuntos
Anestésicos Locais/administração & dosagem , Carticaína/administração & dosagem , Dente Serotino/cirurgia , Extração Dentária/métodos , Adolescente , Adulto , Anestesia Dentária/métodos , Anestésicos Locais/efeitos adversos , Anti-Inflamatórios não Esteroides/uso terapêutico , Perda Sanguínea Cirúrgica , Pressão Sanguínea/fisiologia , Carticaína/efeitos adversos , Estudos Cross-Over , Método Duplo-Cego , Feminino , Seguimentos , Frequência Cardíaca/fisiologia , Humanos , Masculino , Mandíbula/cirurgia , Bloqueio Nervoso/métodos , Oxigênio/sangue , Dor Pós-Operatória/prevenção & controle , Piroxicam/uso terapêutico , Segurança , Dente Impactado/cirurgia , Resultado do Tratamento , Cicatrização/fisiologia , Adulto JovemRESUMO
Bacteria antimicrobial resistance is an uncontrolled public health problem that progressively increases its magnitude and complexity. The Grupo Colaborativo de Resistencia, formed by a join of experts that represent 39 Chilean health institutions has been concerned with bacteria antimicrobial susceptibility in our country since 2008. In this document we present in vitro bacterial susceptibility accumulated during year 2012 belonging to 28 national health institutions that represent about 36% of hospital discharges in Chile. We consider of major importance to report periodically bacteria susceptibility so to keep the medical community updated to achieve target the empirical antimicrobial therapies and the control measures and prevention of the dissemination of multiresistant strains.
Assuntos
Antibacterianos/farmacologia , Bactérias Gram-Negativas/efeitos dos fármacos , Bactérias Gram-Positivas/efeitos dos fármacos , Chile , Comportamento Cooperativo , Resistência Microbiana a Medicamentos , Bactérias Gram-Negativas/classificação , Bactérias Gram-Positivas/classificação , Humanos , Testes de Sensibilidade Microbiana , Vigilância da População , Sociedades MédicasRESUMO
Bacteria antimicrobial resistance is an uncontrolled public health problem that progressively increases its magnitude and complexity. The Grupo Colaborativo de Resistencia, formed by a join of experts that represent 39 Chilean health institutions has been concerned with bacteria antimicrobial susceptibility in our country since 2008. In this document we present in vitro bacterial susceptibility accumulated during year 2012 belonging to 28 national health institutions that represent about 36% of hospital discharges in Chile. We consider of major importance to report periodically bacteria susceptibility so to keep the medical community updated to achieve target the empirical antimicrobial therapies and the control measures and prevention of the dissemination of multiresistant strains.
La resistencia bacteriana es un problema de salud pública que lejos de estar controlado, aumenta en cantidad y complejidad. El Grupo Colaborativo de Resistencia, es un conjunto de profesionales que representan a 39 establecimientos de salud del país y que se ha ocupado desde 2008 de recolectar información sobre la susceptibilidad antimicrobiana de bacterias en Chile. En este documento se presenta la susceptibilidad in vitro acumulada del año 2012, de 28 establecimientos de salud del país que representan, al menos, 36% de los egresos hospitalarios de Chile. Consideramos de la mayor relevancia reportar periódicamente la susceptibilidad bacteriana de modo de mantener a la comunidad médica actualizada para orientar las terapias empíricas y las medidas de control y prevención de la diseminación de cepas multi-resistentes.
Assuntos
Humanos , Antibacterianos/farmacologia , Bactérias Gram-Negativas/efeitos dos fármacos , Bactérias Gram-Positivas/efeitos dos fármacos , Chile , Comportamento Cooperativo , Resistência Microbiana a Medicamentos , Bactérias Gram-Negativas/classificação , Bactérias Gram-Positivas/classificação , Testes de Sensibilidade Microbiana , Vigilância da População , Sociedades MédicasRESUMO
An experimental and theoretical study of the flow of liquid films around a stationary horizontal cylinder is reported. The film presents two different behaviors: The flow is stable in the upper zone (up to â¼150° with the vertical) and Rayleigh-Taylor-like instabilities appear in the lower zone. For the stable region, film thickness evolution could be described by numerically integrating an evolution equation obtained using a lubrication approximation. For the unstable region, a linear stability analysis allows us to determine the maximum growth wavelength for the Rayleigh-Taylor instability. Approximate analytical solutions were obtained for generatrices at an angle with the vertical θ=0 (stable region) and θ=π (where the instability appears).
RESUMO
La diabetes mellitus (DM) va en aumento en nuestro país, con alta prevalencia de complicaciones especialmente por mal control metabólico. Objetivo: evaluar asociación de condición de salud, variables sociodemográficas y años de diagnóstico con satisfacción del paciente con características del tratamiento de diabetes. Material y método: estudio de prevalencia en 340 pacientes de 1.100 usuarios DM2 controlados en Programa Cardiovascular de un Centro de Salud Familiar (CESFAM) de Macul, Región Metropolitana, Chile, previo consentimiento informado. Muestreo aleatorio simple (confianza 95 por ciento, merma 10 por ciento). Recolección de información en CESFAM y/o visita domiciliaria por investigadoras e internas de enfermería entrenadas. Satisfacción del paciente, medida con subescala satisfacción del cuestionario Diabetes Quality of Life (EsDQOL). Análisis con estadística descriptiva, Chi2, Odd Ratios, IC (95 por ciento). Resultados: Población mayoritariamente adulta mayor, femenina, promedio años estudio 8,7. El 42,6 por ciento tiene diagnóstico de DM hace más de 10 años. Refieren mayor satisfacción con: tratamiento medicamentoso, controles recibidos, vida en general. Existe mayor insatisfacción con: tiempo ocupado en ejercicios, cómo duerme, vida sexual. Satisfacción con tratamiento medicamentoso se asocia a compensación de diabetes (p= 0,026). Pacientes insatisfechos con tratamiento tienen 2 veces más riesgo de descompensación que los satisfechos, IC [1,08-3,7]. Insatisfacción con tiempo dedicado a enfermedad, controles, tiempo ocupado en controles y ejercicio indicado se asocian a complicaciones (p < 0,05). Conclusión: Insatisfacción con características del tratamiento de DM2 se asocia mayormente a complicaciones que a compensación de DM, pacientes insatisfechos tienen más riesgo de complicaciones que los satisfechos.
Diabetes Mellitus is increasing in our country, with a high prevalence of complications mainly because of poor metabolic control. Objectives: to evaluate association of health condition, demographic variables, and years since diagnosis with patient satisfaction regarding disease treatment. Methodology: prevalence study, 340 patient taken out of a population of 1.100 patients attended in the Cardiovascular Program of an outpatient clinic in Macul district. Informed consent was requested. Simple randomized sample (CI 95 percent, loss 10 percent). Data collected in the outpatient clinic or through home visits done by researchers or trained senior nursing students. Patient satisfaction was measured by the satisfaction subscale of the Diabetes Quality of Life Questionnaire (EsDQOL). Analysis: descriptive statistics, Chi2, Odds Ratios, CI (95 percent). Results: Population of mainly older adults, female, average years of school attendance 8.7. 42.6 percent has been diagnosed since more than 10 years. They refer greater satisfaction with: pharmacologic treatment, care received in outpatient visits, life in general. There exists more dissatisfaction with: time spent in exercise, sleep, sexual life. Satisfaction with pharmacologic treatment has association with diabetes compensation (p= 0.026). Patients dissatisfed with treatment have 2 times more risk of poor metabolic control than satisfed patients, IC[1.08-3.7]. Dissatisfaction with time spent in the disease, outpatient visits, and time spent in exercises, are associated with complications (p < 0.05). Conclusion: Dissatisfaction is more associated to complications than to poor metabolic control. Patient dissatisfed have more risk of complications than those satisfed.
Assuntos
Feminino , Pessoa de Meia-Idade , /enfermagem , Medicina de Família e Comunidade , Nível de Saúde , Enfermagem de Atenção Primária , Distribuição de Qui-Quadrado , Chile , /terapia , Satisfação do Paciente , Atenção Primária à Saúde , Qualidade de Vida , Fatores Socioeconômicos , Inquéritos e QuestionáriosRESUMO
Chemotherapy-induced nausea and vomiting (CINV) is a major determinant of quality of life in cancer patients. In addition, the perceptions that oncology professionals have about CINV quite often do not coincide with reality. Antineoplastic agents and their combinations can be categorised according to their emetogenic level, and this categorisation is helpful for classifying the severity of CINV and treating it. All CINV treatment guidelines emphasise the need to administer prophylaxis to patients who receive highly or moderately emetogenic chemotherapy. With the introduction of NK1 receptor antagonists, the control of acute and delayed CINV after highly or moderately emetogenic chemotherapy schedules has improved in the great majority of patients. NK1 receptor antagonists have been demonstrated to improve the control of CINV in all risk subgroups of patients.
Assuntos
Antineoplásicos/efeitos adversos , Náusea/induzido quimicamente , Vômito/induzido quimicamente , Antieméticos/administração & dosagem , Antineoplásicos/uso terapêutico , Humanos , Náusea/tratamento farmacológico , Náusea/fisiopatologia , Vômito/tratamento farmacológico , Vômito/fisiopatologiaRESUMO
Hybrid mesoporous materials are potentially useful for metal ion scavenging and retrieval because of their high surface areas, controlled accessibility and tailored functionalization. Some aspects that are linked to the performance of HMM include pore accessibility, stability of the organic functions and reusability. Knowledge of these aspects is critical in the design of adsorption-desorption protocols. In this work we produce and characterize propylamino-substituted large pore silica (SBA-15-N), which is submitted to Cu(II) adsorption from copper sulfate solutions, followed by desorption in acid media and material regeneration. We find that the hybrid material is an efficient adsorbent (1.15-1.75mmol Cu(II)g(-1)), although a fraction of the organic groups is lost during the adsorption process. An X-ray photoelectron spectroscopy (XPS) study demonstrates that the contents of amino groups are higher in the material surface, leading to different behaviors in Cu(II) complexation along the material. These materials can be regenerated by exposure to acidic media. Thermal processing of the hybrid materials leads to better durability in aqueous solutions during reprocessing, due to enhanced polycondensation of the inorganic framework. Thermally treated samples, once regenerated, are efficient adsorbents in a second step of Cu(II) adsorption. We discuss the materials processing factors involved in the improved adsorption of Cu(II), its quantitative release and reusability of the material.