RESUMO
INTRODUCTION/OBJECTIVES: Although inflammation in disc hernia (DH) has been recognized and it is a well-known process mediated by loss of the cellular redox balance, only a few studies about the impact of chronic oxidative stress on this neurological disorder have been made. Ozone therapy has been widely used with clinical efficacy in DH. This work aimed at characterizing the systemic redox status of patients with low back pain and neck pain as well as studying if ozone oxidative post-conditioning modified the pathological oxidative stress and protected against oxidative protein damage and if there is any relationship between oxidative changes and pain in both DH. METHODS: Redox status of 33 patients with diagnosis of DH by computerized axial tomography, nuclear magnetic resonance, and clinical evaluations was studied. Ozone was administered by paravertebral way. After ozone treatment, plasmatic levels of antioxidant/pro-oxidant markers, pain, and life quality disability parameters were evaluated. RESULTS: One hundred percent of patients showed a severe oxidative stress. Major changes in superoxide dismutase activity, total hydroperoxides, advanced oxidation protein products, fructolysine content, and malondialdehyde were observed. After ozone oxidative post-conditioning, there was a re-establishment of patients' cellular redox balance as well as a decrease in pain in both DH. A relationship between indicators of oxidative protein damage and pain was demonstrated. CONCLUSIONS: Ozone therapy protected against oxidation of proteins and reduced the pain. Relationship between markers of oxidative protein damage, disability parameters, and pain suggests the role of oxidative stress in the pathological processes involved in DH.
Assuntos
Deslocamento do Disco Intervertebral/tratamento farmacológico , Estresse Oxidativo/efeitos dos fármacos , Ozônio/uso terapêutico , Adulto , Biomarcadores/metabolismo , Feminino , Humanos , Deslocamento do Disco Intervertebral/metabolismo , Masculino , Pessoa de Meia-Idade , Oxirredução/efeitos dos fármacos , Ozônio/administração & dosagem , Ozônio/farmacologia , Proteínas/metabolismo , Adulto JovemRESUMO
BACKGROUND: The relationship and behavior of serum immunoglobulin E (IgE) level, peripheral blood mononuclear cell (PBMC) human leukocyte antigen DR (HLA-DR) expression and erythrocyte glutathione antioxidant pathway in asthma patients treated with systemic ozone therapy have not been studied before. METHODS: Asthma patients were treated about 1 year with three cycles (5 or 6 months each) with three different ozone therapy protocols. Ozone major autohemotherapy (MAHT) was applied at doses of 4 and 8 mg, 15 sessions each cycle; and ozone rectal insufflations (RI) at a dose of 10 mg, 20 sessions each cycle. Serum IgE, HLA-DR expression in PBMC and biomarkers for antioxidant pathway were measured before and at the end of each cycle. Lung function and symptoms test were recorded at the beginning and after the third cycle. RESULTS: IgE and HLA-DR decreased with the three types of treatments, while increments in reduced glutathione, glutathione peroxidase, glutation reductase and glutathione S-transferase were achieved with all treatments. Lung function and symptoms test were markedly improved. However, in all parameters the best response was obtained in the order: MAHT at 8 mg better than MAHT at 4 mg better than RI at 10 mg. Before ozone treatment, glutathione antioxidant parameters were under the normal reference values, suggesting the occurrence of oxidative stress associated with atopic asthma. CONCLUSIONS: This study demonstrates the effectiveness of ozone therapy in reducing IgE and inflammatory mediators along with the induction of antioxidant elements. The study raises the role of systemic ozone therapy in atopic asthma by means of its immunomodulatory and oxidative stress regulation properties.
Assuntos
Asma/terapia , Biomarcadores , Pulmão/fisiologia , Oxidantes Fotoquímicos/uso terapêutico , Ozônio/uso terapêutico , Adolescente , Adulto , Antioxidantes/metabolismo , Asma/imunologia , Hiper-Reatividade Brônquica , Feminino , Glutationa/metabolismo , Glutationa Peroxidase/metabolismo , Glutationa Redutase/metabolismo , Glutationa Transferase/metabolismo , Antígenos HLA-DR/sangue , Antígenos HLA-DR/imunologia , Humanos , Imunoglobulina E/sangue , Imunoglobulina E/imunologia , Masculino , Pessoa de Meia-IdadeRESUMO
Se estudió el efecto de la ozonoterapia combinada (OLEOZON® oral y ozonoterapia rectal) en el síndrome de malabsorción intestinal, secundario a parasitismo intestinal por Giardia lamblia. Se tomaron 186 pacientes y se formaron 3 grupos de 62 pacientes cada uno. El primer grupo se trató con metronidazol y vitaminoterapia, el segundo con OLEOZON® oral y vitaminoterapia y el tercero con ozonoterapia combinada y vitaminoterapia. Los pacientes fueron evaluados clínicamente por drenaje biliar y biopsia de yeyuno al inicio y final del tratamiento. Se alcanzó una mejoría importante en el tercer grupo (66,1 por ciento), de los cuales, los diagnosticados tempranamente, 40,3 por ciento obtuvo su curación. Se concluyó que la ozonoterapia combinada puede ser eficaz en esta patología