RESUMO
OBJECTIVE: To evaluate the diagnostic utility of routine gastric biopsies taken at random versus targeted biopsies with methylene blue staining for the diagnosis of intestinal metaplasia. MATERIAL AND METHODS: We performed a validation study in 376 patients. We performed 2 antral biopsies, 2 gastric body biopsies, 1 biopsy for urease test and additional biopsies if demanded. One hundred and one patients underwent 2 biopsies after methylene blue staining. A total of 1,486 biopsies were analyzed. Frequencies of histological and endoscopic diagnosis and the validation of endoscopic diagnosis of intestinal metaplasia with and without staining against histology, which followed updated Sydney and Vienna criteria, were determined RESULTS: Metaplasia was found in 37.23% ofcases and in 6.38% was incomplete in antrum and body, moderate or severe. The endoscopic diagnosis had: sensitivity 46%, specificity 91%, positive predictive value (PPV) 75% and negative predictive value (NPV) 74%. The low sensitivity indicates the need for gastric biopsies. Staining had: sensitivity 95%, specificity 67%, PPV 84% and NPV 89%, with significant difference for staining (P < 0.05). The typical endoscopic appearance of intestinal metaplasia always coincided with staining and histology. Dysplasia was found in 0.53% ofcases, gastric cancer in 1.8% and Helicobacter pylori in 56%. CONCLUSION: Directed biopsy staining is superior to those taken at random for diagnosing metaplasia. Metaplasia was not found when endoscopy was normal and typical endoscopic appearance of metaplasia agreed with staining and histology.
Assuntos
Mucosa Gástrica/patologia , Mucosa Intestinal/patologia , Azul de Metileno , Biópsia/métodos , Endoscopia Gastrointestinal/métodos , Feminino , Humanos , Masculino , Metaplasia/patologia , Pessoa de Meia-Idade , Valor Preditivo dos Testes , Estudos Prospectivos , Sensibilidade e Especificidade , Índice de Gravidade de Doença , Coloração e Rotulagem/métodosRESUMO
OBJECTIVE: To evaluate the diagnostic utility of routine gastric biopsies taken at random versus targeted biopsies with methylene blue staining for the diagnosis of intestinal metaplasia. MATERIAL AND METHODS: We performed a validation study in 376 patients. We performed 2 antral biopsies, 2 gastric body biopsies, 1 biopsy for urease test and additional biopsies if demanded. One hundred and one patients underwent 2 biopsies after methylene blue staining. A total of 1,486 biopsies were analyzed. Frequencies of histological and endoscopic diagnosis and the validation of endoscopic diagnosis of intestinal metaplasia with and without staining against histology, which followed updated Sydney and Vienna criteria, were determined RESULTS: Metaplasia was found in 37.23
ofcases and in 6.38
was incomplete in antrum and body, moderate or severe. The endoscopic diagnosis had: sensitivity 46
, specificity 91
, positive predictive value (PPV) 75
and negative predictive value (NPV) 74
. The low sensitivity indicates the need for gastric biopsies. Staining had: sensitivity 95
, specificity 67
, PPV 84
and NPV 89
, with significant difference for staining (P < 0.05). The typical endoscopic appearance of intestinal metaplasia always coincided with staining and histology. Dysplasia was found in 0.53
ofcases, gastric cancer in 1.8
and Helicobacter pylori in 56
. CONCLUSION: Directed biopsy staining is superior to those taken at random for diagnosing metaplasia. Metaplasia was not found when endoscopy was normal and typical endoscopic appearance of metaplasia agreed with staining and histology.
Assuntos
Mucosa Gástrica/patologia , Mucosa Intestinal/patologia , Azul de Metileno/diagnóstico , Biópsia/métodos , Endoscopia Gastrointestinal/métodos , Feminino , Humanos , Masculino , Metaplasia/patologia , Pessoa de Meia-Idade , Valor Preditivo dos Testes , Estudos Prospectivos , Sensibilidade e Especificidade , Índice de Gravidade de Doença , Coloração e Rotulagem/métodosRESUMO
OBJECTIVE: To evaluate the diagnostic utility of routine gastric biopsies taken at random versus targeted biopsies with methylene blue staining for the diagnosis of intestinal metaplasia. MATERIAL AND METHODS: We performed a validation study in 376 patients. We performed 2 antral biopsies, 2 gastric body biopsies, 1 biopsy for urease test and additional biopsies if demanded. One hundred and one patients underwent 2 biopsies after methylene blue staining. A total of 1,486 biopsies were analyzed. Frequencies of histological and endoscopic diagnosis and the validation of endoscopic diagnosis of intestinal metaplasia with and without staining against histology, which followed updated Sydney and Vienna criteria, were determined RESULTS: Metaplasia was found in 37.23
ofcases and in 6.38
was incomplete in antrum and body, moderate or severe. The endoscopic diagnosis had: sensitivity 46
. The low sensitivity indicates the need for gastric biopsies. Staining had: sensitivity 95
, with significant difference for staining (P < 0.05). The typical endoscopic appearance of intestinal metaplasia always coincided with staining and histology. Dysplasia was found in 0.53
ofcases, gastric cancer in 1.8
and Helicobacter pylori in 56
. CONCLUSION: Directed biopsy staining is superior to those taken at random for diagnosing metaplasia. Metaplasia was not found when endoscopy was normal and typical endoscopic appearance of metaplasia agreed with staining and histology.
Assuntos
Azul de Metileno/diagnóstico , Mucosa Gástrica/patologia , Mucosa Intestinal/patologia , Biópsia/métodos , Coloração e Rotulagem/métodos , Endoscopia Gastrointestinal/métodos , Estudos Prospectivos , Feminino , Humanos , Masculino , Metaplasia/patologia , Pessoa de Meia-Idade , Sensibilidade e Especificidade , Valor Preditivo dos Testes , Índice de Gravidade de DoençaRESUMO
BACKGROUND: The BISAP score is a simple system, which englobes clinical features (laboratory and imagenology tests) allowing to predict the mortality in acute pancreatitis within the first 24 hours of hospitalization. OBJECTIVE: To determine the validity of the BISAP score in the prediction of prognosis and severity of acute pancreatitis. METHOD: In order to validate the BISAP score, a study was performed in 57 patients with a diagnosis of acute pancreatitis at the moment of admission. The reference test was the Atlanta criteria which confirmed severe clinical course beyond the fifth day, in many cases supported by CT. RESULTS: 71.9% were women. The mean age was 45.33 years. Biliary lithiasis was the most frequent cause (66.7%). According to the reference test 71.9% were mild and 28.1% severe. According to the BISAP score 77.2% mild and 22.8% severe. The sensitivity and specificity for the BISAP score was of 75% and 97.56% respectively. The predictive positive value was 92.31% and the predictive negative value was 90.91%. CONCLUSIONS: The BISAP score allows to predict the severity of the acute pancreatitis.
Assuntos
Pancreatite/diagnóstico , Índice de Gravidade de Doença , Doença Aguda , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Pancreatite/etiologia , Valor Preditivo dos Testes , Prognóstico , Sensibilidade e Especificidade , Adulto JovemRESUMO
INTRODUCCIÓN: El score de BISAP es un sistema no complicado y factible de realizar en hospitales de referencia como el nuestro, engloba variables clínicas, de laboratorio y de imagen, permitiendo predecir la mortalidad por pancreatitis aguda, dentro de las 24 horas de inicio del cuadro clínico. OBJETIVO: Determinar la validez del score de BISAP en la gravedad y el pronóstico de la Pancreatitis Aguda. MÉTODO: Estudio de validación del score de BISAP en 57 pacientes consecutivos con diagnóstico de pancreatitis aguda al ingreso. Prueba de referencia: los criterios de Atlanta confirmados por evolución clínica grave más allá del quinto día, apoyados en muchos casos por TAC. RESULTADOS: El 71.9% fueron de sexo femenino. La media de edad fue de 45.33 años. La litiasis biliar fue la causa más frecuente (66.7%). Según la prueba de referencia, el 71.9% de casos fueron leves y el 28.1% graves. Según el score de BISAP el 77.2% leves y el 22.8% graves. La sensibilidad y especificidad para el score de BISAP fue del 75% y del 97.56% respectivamente. El valor predictivo positivo fue del 92.31% y el valor predictivo negativo, del 90.91%. CONCLUSIONES: El score de BISAP permite predecir la severidad en la pancreatitis aguda.
BACKGROUND: The BISAP score is a simple system, which englobes clinical features (laboratory and imagenology tests) allowing to predict the mortality in acute pancreatitis within the first 24 hours of hospitalization. OBJECTIVE: To determine the validity of the BISAP score in the prediction of prognosis and severity of acute pancreatitis. METHOD: In order to validate the BISAP score, a study was performed in 57 patients with a diagnosis of acute pancreatitis at the moment of admission. The reference test was the Atlanta criteria which confirmed severe clinical course beyond the fifth day, in many cases supported by CT. RESULTS: 71.9% were women. The mean age was 45.33 years. Biliary lithiasis was the most frequent cause (66.7%). According to the reference test 71.9% were mild and 28.1% severe. According to the BISAP score 77.2% mild and 22.8% severe. The sensitivity and specificity for the BISAP score was of 75% and 97.56% respectively. The predictive positive value was 92.31% and the predictive negative value was 90.91%. CONCLUSIONS: The BISAP score allows to predict the severity of the acute pancreatitis.