RESUMO
A new palladium(II) complex with methionine sulfoxide was synthesized and characterized by a set of chemical and spectroscopic techniques. Elemental and mass spectrometry analyses of the solid complex fit to the composition [Pd(C5H10NO3S)2].H2O. 13C NMR, [1H-15N] NMR and infrared spectra indicate coordination of the amino acid to Pd(II) through the carboxylate and amino groups in a square planar geometry. The complex is soluble in water. Biological activity was evaluated by cytotoxic analysis using HeLa cells. Determination of cell death was assessed using a tetrazolium salt colorimetric assay, which reflects the cells viability. After incubation for 48 h, 20% of cell death was achieved at a concentration of 200 micromol L-1 of the complex.
Assuntos
Metionina/análogos & derivados , Paládio/química , Paládio/metabolismo , Morte Celular/efeitos dos fármacos , Células HeLa , Humanos , Espectroscopia de Ressonância Magnética , Espectrometria de Massas , Metionina/síntese química , Metionina/química , Metionina/metabolismo , Metionina/farmacologia , Paládio/farmacologia , Espectrofotometria InfravermelhoRESUMO
Fundamenta a discussäo sobre a importância do selênio como um dos minerais superativo no processo de envelhecimento.