RESUMO
UNLABELLED: The role of lead (Pb) as an environmental cause of nephropathy is difficult to ascertain due to the difficulty to determine clinically its exposure. AIM: To assess lead levels and renal function in a group of males working in mechanical workshops. MATERIAL AND METHODS: Blood and urine samples were obtained from 100 mechanical workshop workers aged 38 ± 16 years and 95 non-exposed office clerks aged 37 ± 17 years. Blood lead and creatinine levels were determined. In exposed workers, urinary excretion of intestinal alkaline phosphatases (IAP) and N-acetyl-glucosaminidase (NAG) were measured as early markers of renal failure. RESULTS: Blood lead levels were 66.4 ± 43 and 33.6 ± 18 µg/L among mechanical workshop workers and non-exposed controls, respectively, p < 0.01. The figures for serum creatinine were 0.9 ± 0.1 and 0.9 ± 0.1 respectively, p = NS. Among exposed workers urinary excretion of IAP was 0.47 ± 0.6 U/L and of NAG, 0.92 ± 1.1 U/L. There was a positive correlation between blood lead levels and NAG excretion (r = 0.284) and IAP excretion (r = 0.346). CONCLUSIONS: Exposed workers had higher blood lead levels and there was a weak positive association between these levels and the urinary excretion of NAG and IAP.
Assuntos
Creatinina/sangue , Chumbo/sangue , Exposição Ocupacional/efeitos adversos , Insuficiência Renal/induzido quimicamente , Acetilglucosaminidase/urina , Adulto , Fosfatase Alcalina/urina , Biomarcadores/sangue , Estudos de Casos e Controles , Humanos , Chumbo/efeitos adversos , Masculino , Insuficiência Renal/diagnósticoRESUMO
The role of lead (Pb) as an environmental cause of nephropathy is difficult to ascertain due to the difficulty to determine clinically its exposure. Aim: To assess lead levels and renal function in a group of males working in mechanical workshops. Material and Methods: Blood and urine samples were obtained from 100 mechanical workshop workers aged 38 ± 16 years and 95 non-exposed office clerks aged 37 ± 17 years. Blood lead and creatinine levels were determined. In exposed workers, urinary excretion of intestinal alkaline phosphatases (IAP) and N-acetyl-glucosaminidase (NAG) were measured as early markers of renal failure. Results: Blood lead levels were 66.4 ± 43 and 33.6 ± 18 µg/L among mechanical workshop workers and non-exposed controls, respectively, p < 0.01. The figures for serum creatinine were 0.9 ± 0.1 and 0.9 ± 0.1 respectively, p = NS. Among exposed workers urinary excretion of IAP was 0.47 ± 0.6 U/L and of NAG, 0.92 ± 1.1 U/L. There was a positive correlation between blood lead levels and NAG excretion (r = 0.284) and IAP excretion (r = 0.346). Conclusions: Exposed workers had higher blood lead levels and there was a weak positive association between these levels and the urinary excretion of NAG and IAP.
Assuntos
Humanos , Masculino , Adulto , Exposição Ocupacional/efeitos adversos , Creatinina/sangue , Insuficiência Renal/induzido quimicamente , Chumbo/sangue , Acetilglucosaminidase/urina , Biomarcadores/sangue , Estudos de Casos e Controles , Fosfatase Alcalina/urina , Insuficiência Renal/diagnóstico , Chumbo/efeitos adversosRESUMO
Hemos realizado un estudio transversal, descriptivo con componente analítico en 30 pacientes en hemodiálisis crónica, en ambos sexos, mayores de 18 años, que se dializan 4 horas, 3 veces por semana, con baño de acetato, con la intención de determinar la incidencia y las causas de hipertrofia ventricular izquierda. Se realizó una ecocardiografía Doppler y dosaje de hemoglobina, albúmina y medición de PA. Se consideró hipertrofia ventricular izquierda cuando la masa del ventrículo izquierdo era mayor a 125 g/m2 en varones y a 110 g/m2 en mujeres. Hipertensión arterial _ 140/90. La hemoglobina fue de 7,8±1,8 g/dl, albúmina de 3,9±0,5g por ciento, PA de 132,7±20,7 / 80,2±9,7; siendo hipertensos el 33 por ciento (154,3±10,6 / 88,1±6,2) y normotensos el 67 por ciento (121,3±14,6 / 70,1±8,7). En la ecocardiografía se constató hipertrofia ventricular izquierda con una masa de 203,4±53,9 g/m2, encontrándose correlación entre la hipertrofia y la hemoglobina (r= -0,40); la hipertrofia y la presión arterial sistólica (r= 0,45); la hipertrofia y la presión arterial diastólica (r= 0,54); no habiendo correlación con el nivel de albúmina o el tiempo en diálisis. En la ecocardiografía; el espesor del tabique interventricular 12,1±1,9 mm en mujeres y 13,4±1,7 mm en varones (p< 0,05); el espesor de la pared posterior del VI 11,3±1,3 mm en mujeres y 12,5±0,9 mm en varones (p <0,05). Todos los pacientes en hemodiálisis presentaron hipertrofia ventricular izquierda, sin embargo el 67 por ciento eran normotensos. La etiología de la hipertrofia ventricular en los pacientes en hemodiálisis crónica es multifactorial, relacionada en nuestro estudio con la anemia y los niveles de presión arterial, principalmente la diastólica.Taquicardia auricular focal y extrasístoles auriculares frecuentes: Aspectos electrofisiológicos, implicancia clínica y ablación percutánea exitosa con catéter por radiofrecuencia