RESUMO
Angiosarcoma is a rare and aggressive tumor with high rates of metastasis and relapse. It shows a particular predilection for the skin and superficial soft tissues. We report three distinct and typical cases of angiosarcoma that were diagnosed in a single dermatology clinic over the course of less than a year: i) Angiosarcoma in lower limb affected by chronic lymphedema, featuring Stewart-Treves syndrome; ii) a case of the most common type of angiosarcoma loated in the scalp and face of elderly man and; iii) a skin Angiosarcoma in previously irradiated breast. All lesions presented characteristic histopathological findings: irregular vascular proliferation that dissects the collagen bundles with atypical endothelial nuclei projection toward the lumen.
Assuntos
Neoplasias de Cabeça e Pescoço/patologia , Hemangiossarcoma/patologia , Couro Cabeludo/patologia , Neoplasias Cutâneas/patologia , Adulto , Idoso de 80 Anos ou mais , Mama/patologia , Feminino , Humanos , Perna (Membro)/patologia , Linfangiossarcoma , Linfedema/complicações , Masculino , Pessoa de Meia-Idade , Fatores de RiscoRESUMO
Abstract: Angiosarcoma is a rare and aggressive tumor with high rates of metastasis and relapse. It shows a particular predilection for the skin and superficial soft tissues. We report three distinct and typical cases of angiosarcoma that were diagnosed in a single dermatology clinic over the course of less than a year: i) Angiosarcoma in lower limb affected by chronic lymphedema, featuring Stewart-Treves syndrome; ii) a case of the most common type of angiosarcoma loated in the scalp and face of elderly man and; iii) a skin Angiosarcoma in previously irradiated breast. All lesions presented characteristic histopathological findings: irregular vascular proliferation that dissects the collagen bundles with atypical endothelial nuclei projection toward the lumen.
Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Idoso de 80 Anos ou mais , Couro Cabeludo/patologia , Neoplasias Cutâneas/patologia , Neoplasias de Cabeça e Pescoço/patologia , Hemangiossarcoma/patologia , Mama/patologia , Fatores de Risco , Perna (Membro)/patologia , Linfangiossarcoma , Linfedema/complicaçõesRESUMO
Abstract Lucio’s phenomenon is an uncommon reaction characterized by severe necrotizing cutaneous lesions that occurs in patients with Lucio’s leprosy and lepromatous leprosy. It is considered by some authors as a variant of type 2 or 3 reaction. Death can occur because of blood dyscrasia or sepsis. Precipitating factors include infections, drugs and pregnancy. We report a 31-year-old female patient exhibiting both clinical and histopathological features of lepromatous leprosy and Lucio’s phenomenon presenting favorable response to treatment. We complement our report with a literature review of the Brazilian cases of Lucio’s phenomenon published in Portuguese and English.
Assuntos
Humanos , Feminino , Adulto , Úlcera Cutânea/patologia , Hanseníase Virchowiana/patologia , Pele/patologia , Úlcera Cutânea/tratamento farmacológico , Biópsia , Índice de Gravidade de Doença , Brasil , Hanseníase Virchowiana/tratamento farmacológico , Resultado do Tratamento , NecroseRESUMO
Lucio's phenomenon is an uncommon reaction characterized by severe necrotizing cutaneous lesions that occurs in patients with Lucio's leprosy and lepromatous leprosy. It is considered by some authors as a variant of type 2 or 3 reaction. Death can occur because of blood dyscrasia or sepsis. Precipitating factors include infections, drugs and pregnancy. We report a 31-year-old female patient exhibiting both clinical and histopathological features of lepromatous leprosy and Lucio's phenomenon presenting favorable response to treatment. We complement our report with a literature review of the Brazilian cases of Lucio's phenomenon published in Portuguese and English.