RESUMO

This study used [3H]dizocilpine (MK-801) binding to the N-methyl-D-aspartate (NMDA) receptor to examine glycine, redox and zinc modulatory sites in membranes derived from the frontal and parietal cortex of control subjects (n = 8) and suicide victims (n = 6). [3H]dizocilpine binding in the presence of glutamate and glutamate plus glycine was similar in control and suicide subjects. The sulphydryl redox site was assessed using the oxidizing agent 5,5'-dithio-bis (2-nitrobenzoic acid), which inhibited binding in a dose-dependent fashion. Both redox and zinc sites were unaffected in the frontal and parietal cortex of suicide victims. These data indicate that the NMDA receptor and its glycine, redox and zinc subsites are preserved in the neocortex of suicide victims.

Assuntos

Química Encefálica , Maleato de Dizocilpina/metabolismo , Glicina/farmacologia , Receptores de N-Metil-D-Aspartato/efeitos dos fármacos , Suicídio , Zinco/farmacologia , Adulto , Feminino , Lobo Frontal/química , Ácido Glutâmico/farmacologia , Humanos , Canais Iônicos/efeitos dos fármacos , Masculino , Oxirredução , Receptores de N-Metil-D-Aspartato/metabolismo