RESUMO

Casiopeinas is the generic name of a group of coordination complexes with a central copper atom bound to organic ligands, designed to be an alternative to cancer therapy. Indeed, some of these compounds can reduce implanted tumors in mice. Casiopeinas were expressly designed to interact with the genetic material, so the aim of the present work is to determine if these compounds have genotoxic activity. The results indicate that casiopeinas produce DNA fragmentation and base oxidation and suggest that their mode of action is related to reactive oxygen species (ROS) generation after copper reduction.

Assuntos

Antineoplásicos/toxicidade , Cobre/toxicidade , Fragmentação do DNA/efeitos dos fármacos , Linfócitos/efeitos dos fármacos , Compostos Organometálicos/toxicidade , Animais , Antineoplásicos/química , Ensaio Cometa , Cobre/química , Reparo do DNA , Células HeLa , Humanos , Camundongos , Modelos Moleculares , Estrutura Molecular , Testes de Mutagenicidade , Compostos Organometálicos/química , Oxirredução , Plasmídeos , Relação Estrutura-Atividade