RESUMO
The somatotrophic axis (GH-IGF) is a key regulator of animal growth and development, affecting performance traits that include milk production, growth rate, body composition, and fertility. The aim of this study was to quantify the association of previously identified SNPs in bovine growth hormone (GH1) and insulin-like growth factor 1 (IGF-1) genes with direct performance trait measurements of lactation and fertility in Holstein-Friesian lactating dairy cows. Sixteen SNPs in both IGF-1 and GH1 were genotyped across 610 cows and association analyses were carried out with traits of economic importance including calving interval, pregnancy rate to first service and 305-day milk production, using animal linear mixed models accounting for additive genetic effects. Two IGF-1 SNPs, IGF1i1 and IGF1i2, were significantly associated with body condition score at calving, while a single IGF-1 SNP, IGF1i3, was significantly associated with milk production, including milk yield (means ± SEM; 751.3 ± 262.0 kg), fat yield (21.3 ± 10.2 kg) and protein yield (16.5 ± 8.0 kg) per lactation. Only one GH1 SNP, GH33, was significantly associated with milk protein yield in the second lactation (allele substitution effect of 9.8 ± 5.0 kg). Several GH1 SNPs were significantly associated with fertility, including GH32, GH35 and GH38 with calving to third parity (22.4 ± 11.3 days) (GH32 and GH38 only), pregnancy rate to first service (0.1%) and overall pregnancy rate (0.05%). The results of this study demonstrate the effects of variants of the somatotrophic axis on milk production and fertility traits in commercial dairy cattle.
Assuntos
Composição Corporal/genética , Bovinos/genética , Fertilidade/genética , Hormônio do Crescimento/genética , Fator de Crescimento Insulin-Like I/genética , Lactação/genética , Animais , Bovinos/fisiologia , Feminino , Genótipo , Polimorfismo de Nucleotídeo Único , Regiões Promotoras GenéticasAssuntos
Nicotina/análise , Nitrosaminas/análise , Fumar , Alcatrões/análise , Indústria do Tabaco , Ásia , Austrália , Europa (Continente) , Humanos , México , Estados UnidosRESUMO
PURPOSE: A systematic examination of all available mortality data from benign prostatic hyperplasia (BPH) between 1950 and 1990 was done to estimate the changing international mortality pattern of this condition. MATERIALS AND METHODS: Mortality data in which BPH was the underlying cause of death were abstracted from the World Health Organization mortality data base. These data were available from a variety of international countries (in many since 1950). RESULTS: Mortality rates have decreased with considerable magnitude in developed western countries between the early 1950s and late 1980s. This fact could reasonably be attributed to the improved management of the most severe complications of BPH and to improvements in surgery and anesthesia, which have made surgical interventions of the prostate possible in a greater proportion of men, and safer in the immediate and subsequent postoperative period. CONCLUSIONS: The decreases noted in western countries, such as the United Kingdom (where 8,700 fewer men die each year presently than would be expected if the BPH mortality rates from the early 1950s still applied), United States (13,681 fewer deaths) and France (2,884 fewer deaths), indicate a considerable but unheralded achievement for modern medicine. Unfortunately, these decreases have not been observed to the same extent in central and eastern Europe and South America, where the residual high mortality rates could be lowered by education, and the widespread availability of modern surgical and anesthetic equipment.
Assuntos
Hiperplasia Prostática/mortalidade , Causas de Morte , Europa (Continente)/epidemiologia , Europa Oriental/epidemiologia , Humanos , Masculino , Mortalidade/tendências , América do Sul/epidemiologia , Reino Unido/epidemiologia , Estados Unidos/epidemiologiaRESUMO
It was reported over 20 years ago that there were distinct age-specific patterns of Hodgkin's disease incidence in countries with different levels of economic development, and that there was an inverse relationship between the incidence of Hodgkin's disease in children and young adults within countries. Such observations were important, leading to hypotheses on the possibly infectious aetiology of the disease. Since the initial report, diverging trends in the incidence of Hodgkin's disease in children and young adults have been observed, and data from a much larger number of countries and cancer registries have become available. This led us to reassess international age-related incidence patterns of Hodgkin's disease occurrence. Recent data show distinct differences in age-specific Hodgkin's disease incidence patterns in different geographic regions. In general, the United States (US) and European countries had the pattern of low childhood rates and high young adulthood rates. However, countries which are not part of the European Union (EU), mainly Baltic states and countries of central and eastern Europe, showed a variant of this pattern: similarly high young adult rates, but rates in children higher than those in the US and EU. Incidence-rate patterns for Latin American countries differed from those previously observed, with a shift towards patterns observed in more economically developed countries. Analysis of incidence data from earlier sources dating back to 1963 confirmed the original finding of an inverse association in incidence rates (c. 1963-1967) using a selected group of cancer registries, but not when all data were considered. This association has become weaker over the past 20 years. Using current incidence rates (1983-1987), no association between Hodgkin's disease rates in children aged 5 to 14 years (as well as 0 to 9 years) and young adults (20 to 34 years) was found.
Assuntos
Doença de Hodgkin/epidemiologia , Fatores Etários , Ásia/epidemiologia , Criança , Pré-Escolar , Europa (Continente)/epidemiologia , Humanos , Incidência , Lactente , Recém-Nascido , Masculino , América do Norte , Sistema de Registros , América do Sul/epidemiologiaRESUMO
The purpose of this pilot study was to identify the cost of providing care to Veterans Administration (VA) and Department of Defense (DOD) patients eligible for care in the Emergency Department of the New Mexico Regional Federal Medical Center in Albuquerque, New Mexico. Medical records for the Emergency Department (N = 456) were reviewed for individual medical supply item and medication usage. Cost data were then tabulated for each item and each group, respectively. The results indicated that the DOD and VA shared equally in the consumption of expendable medical supply and medication funds in the Emergency Department.
Assuntos
Serviço Hospitalar de Emergência/economia , Custos de Cuidados de Saúde , Hospitais Militares/economia , Hospitais de Veteranos/economia , Humanos , New Mexico , Projetos PilotoRESUMO
The aerobic heterotrophic bacterial flora in over 200 individuals from 10 wild populations and 3 laboratory colonies of the schistosome vector snail Biomphalaria glabrata was examined. Internal bacterial densities were inversely proportional to snail size and were higher in stressed and laboratory-reared snails. The numerically predominant bacterial genera in individual snails included Pseudomonas, Acinetobacter, Aeromonas, Vibrio, and several members of the Enterobacteriaceae. Enterobacteriaceae seldom predominated in laboratory colonies. Our data suggest that Vibrio extorquens and a Pasteurella sp. tend to predominate in high-bacterial-density snails. These snails may be compromised and may harbor opportunistic snail pathogens.
Assuntos
Bactérias/isolamento & purificação , Biomphalaria/microbiologia , Vetores de Doenças , Controle Biológico de Vetores , Aerobiose , Animais , Enterobacteriaceae/isolamento & purificação , Pasteurella/isolamento & purificação , Pseudomonas/isolamento & purificação , Porto Rico , Especificidade da Espécie , Vibrio/isolamento & purificação , Índias OcidentaisRESUMO
Trends in intellectual functioning before and after diet termination were examined in 30 children with PKU treated before 6 weeks of age and on a liberal diet for a mean of three years since the mean age of 59 months. Comparisons of trends in pre- and posttermination IQ scores with the linear spline technique revealed no significant differences. Comparisons of pretermination IQ scores with posttermination scores and scores from the most recent evaluation also yielded no significant differences. These data fail to support a relationship between termination of diet and impairment of intellectual functioning, at least during this period of observation.