RESUMO
Drimia maritima is a toxic Mediterranean plant and is considered a commercially important drug by its medicinal values and pharmacological properties. In this work, we seek to evaluate the direct and delayed effects of the ethanol extracts of this plant on vinegar fly (Drosophila melanogaster), an excellent laboratory model. The treatment was carried out by ingestion on second-stage larvae (L2) and then we evaluated the impact of this treatment on mortality, development, sexual behaviour, on female's oviposition choice, fecundity, and fertility of adults. The results showed that mortality rates can reach 100% after 15 days of treatment as we recorded an acceleration of the flies' development. After treatment, we observed incomplete nuptial courtship and a significant decrease in eggs laid number and larvae number of the first generation treated. This study indicates that D. maritima ethanolic extract has a neurotoxic property, our results confirmed the presence of toxic secondary metabolites in the extract studied.
Assuntos
Animais , Drimia/toxicidade , Dípteros/efeitos dos fármacos , Larva/crescimento & desenvolvimento , Drosophila melanogasterRESUMO
Drimia maritima is a toxic Mediterranean plant and is considered a commercially important drug by its medicinal values and pharmacological properties. In this work, we seek to evaluate the direct and delayed effects of the ethanol extracts of this plant on vinegar fly (Drosophila melanogaster), an excellent laboratory model. The treatment was carried out by ingestion on second-stage larvae (L2) and then we evaluated the impact of this treatment on mortality, development, sexual behaviour, on female's oviposition choice, fecundity, and fertility of adults. The results showed that mortality rates can reach 100% after 15 days of treatment as we recorded an acceleration of the flies' development. After treatment, we observed incomplete nuptial courtship and a significant decrease in eggs laid number and larvae number of the first generation treated. This study indicates that D. maritima ethanolic extract has a neurotoxic property, our results confirmed the presence of toxic secondary metabolites in the extract studied.(AU)
Assuntos
Animais , Drimia/toxicidade , Dípteros/efeitos dos fármacos , Larva/crescimento & desenvolvimento , Drosophila melanogasterRESUMO
Traditional medicinal plants are widely used as immunomodulatory medicines that help improve health. A total of 50 plants used for the treatment of toxicity were screened for their protective effects. Traditional medicinal are globally used and have rapidly grown in economic importance. Intrinsically active compounds are well-known for their antioxidant, anti-tumor, anti-viral, and anti-inflammatory activities. The study was conducted to investigate the effects of the ethanolic extract of C. arabica leaves on sexual behavior in Wistar rats. C. arabica, a medicinal plant with a foul odor, toxic, and hash allucinogenic effects. The experimental study was carried out on white rats (male and female) of the Wistar strain from the Pasteur Institute of Algiers (Kouba, Algeria), weighing between 150 and 200g sexually naive. The animals were raised in polyethylene cages and divided into two groups (n = 10 rats/group), which received a saline solution (male and female control group), 0.20µg/ml of the ethanolic extract of C. arabica leaves for seven days orally (male and female treated group). The sexual behavior test was performed according to three types of crossing. The results of the treated groups showed a significant increase in mating frequency compared to the control group. Overall, the results showed that C. arabica significantly affects sexual behavior. The ethanolic extract of C. arabica increased sexual behavior and orientation activity performance recorded in the treated animals. Thus, this study found that C. arabica has a significant effect on the rats' sexual behavior.
Assuntos
Animais , Camundongos , Cleome , Comportamento Sexual Animal/efeitos dos fármacos , Ratos WistarRESUMO
Traditional medicinal plants are widely used as immunomodulatory medicines that help improve health. A total of 50 plants used for the treatment of toxicity were screened for their protective effects. Traditional medicinal are globally used and have rapidly grown in economic importance. Intrinsically active compounds are well-known for their antioxidant, anti-tumor, anti-viral, and anti-inflammatory activities. The study was conducted to investigate the effects of the ethanolic extract of C. arabica leaves on sexual behavior in Wistar rats. C. arabica, a medicinal plant with a foul odor, toxic, and has hallucinogenic effects. The experimental study was carried out on white rats (male and female) of the Wistar strain from the Pasteur Institute of Algiers (Kouba, Algeria), weighing between 150 and 200g sexually naive. The animals were raised in polyethylene cages and divided into two groups (n = 10 rats/group), which received a saline solution (male and female control group), 0.20µg/ml of the ethanolic extract of C. arabica leaves for seven days orally (male and female treated group). The sexual behavior test was performed according to three types of crossing. The results of the treated groups showed a significant increase in mating frequency compared to the control group. Overall, the results showed that C. arabica significantly affects sexual behavior. The ethanolic extract of C. arabica increased sexual behavior and orientation activity performance recorded in the treated animals. Thus, this study found that C. arabica has a significant effect on the rats' sexual behavior.(AU)