RESUMO
Cementoblastoma is a rare benign odontogenic neoplasm of ectomesenchymal origin, accounting for fewer than 6% of all odontogenic tumors. Although the tumor characteristics are well known, the standard practice to treat this lesion is surgical excision and extraction of the affected tooth, with few reported cases using a tooth-conservative treatment approach. This report presents the case of a 33-year-old woman with cementoblastoma who underwent conservative treatment to preserve her tooth in the oral cavity. Endodontic treatment of the tooth was performed; 30 days later, the lesion was removed with the apical third of the root of the tooth. After 7 years of follow-up, no recurrence was observed, and the tooth retains its masticatory function. In certain cases of cementoblastoma, the affected tooth can be kept in the oral cavity instead of being extracted, thereby preserving the oral health of patients.
Assuntos
Cementoma , Neoplasias Mandibulares , Tumores Odontogênicos , Adulto , Tratamento Conservador , Feminino , Humanos , Dente MolarRESUMO
Interleukin-33 (IL-33) is a recently described member of the IL-1 family. IL-33 acts as an alarmin, chemoattractant, and nuclear factor. ST2, a member of the Toll-like receptor/IL-1R superfamily, the receptor of IL-33, triggers a plethora of downstream effectors and leads the activation of NFK-B, leading the expression of several genes. IL-33 and ST2 are expressed in the majority of cell types, and the IL-33/ST2 axis has a role in immune response, bone homeostasis, and osteoclastogenesis. Several studies show opposite roles of IL-33 in osteoclastogenesis and the implication in bone biology. Few works studied the role of IL-33 in periodontal disease, but we hypothesize a possible role of IL-33 in periodontal disease and bone loss.