RESUMO
BACKGROUND: Antisynthetase syndrome is an inflammatory myopathy that is characterized by the presence of anti-aminoacyl-tRNA synthetase antibodies. Only 30% of those who suffer from the disease can be identified. We present three Hispanic cases of antisynthetase syndrome with unusual clinical pictures were extended myositis panel results enable disease diagnosis and treatment. CASE PRESENTATION: A 57-year-old Hispanic/Latino female with an erythematous scaly plaque, unresolved fever and non-immune haemolytic anaemia in whom inpatient work-up for fever of unknown origin was positive for anti-PL12 positive myositis extended panel. A 72-year-old Hispanic/Latino male with amyopathic weakness syndrome and mechanic hands in whom impatient work-up was relevant for proximal muscle uptake and anti-PM75 and AntiPL-12 myositis extended panel. And a 67-year-old Hispanic/Latino male with progressive interstitial lung disease and unresolved fever ended in myositis extended panel positive for antiPL-7. After systemic immunosuppressor treatment, patients had favourable clinical and paraclinical responses during outpatient follow-up. CONCLUSIONS: The high variability of the antisynthetase syndrome in these cases demonstrates the importance of identification through an expanded panel and highlights the probability that this is a variable disease and that we need to include emerging molecular tests to promote the timely treatment of patients.
Assuntos
Miosite , Humanos , Pessoa de Meia-Idade , Idoso , Miosite/complicações , Miosite/diagnóstico , Miosite/tratamento farmacológico , Administração Cutânea , Febre , MãosRESUMO
BACKGROUND: Measurement of the optic nerve sheath diameter (ONSD) provides a rapid, safe, and easy method for detecting increased intracranial pressure (ICP). However, the normal mean and upper limit values may vary according to sex, age, ethnicity, and ultrasound technique. AIM: We aimed to obtain the mean ONSD in a healthy Colombian adult population and to correlate it with demographic and anthropometric measures. METHODS: In a prospective study using a 10-13 MHz linear ultrasound probe, eye transverse diameter (ETD) and ONSD in the transverse (ONSD-TP) and sagittal planes (ONSD-SP) were measured in healthy adult volunteers in Bogota, Colombia. RESULTS: A total of 100 healthy subjects were included, with a mean age of 26,7 ± 8,3 years and 62 women. The mean ETD, ONSD-TP and ONSD-SP was 23.11 mm (95% confidence interval (CI): 22.90 mm-23.32 mm), 3.96 mm (95% CI: 3.85 mm-4.07 mm) and 4.0 mm (95% CI: 3.90 mm-4.11 mm), respectively. The ONSD in both planes ranged from 2.35 mm to 5.20 mm. There was a significant correlation between ONSD-SP and ONSD-TP (p < 0.0001) but no correlation between the ocular measures and demographic or anthropometric variables (p > 0.05). The intraclass correlation between the eyes was statistically significant. CONCLUSION: Our study shows that ultrasound-measured ONSD in healthy adults in Colombia is similar to that found worldwide. An ONSD of 5.5 mm may be considered the upper limit for healthy adults in Colombia. ONSD can be measured in either plane; there is a good correlation between the two eyes; and ONSD is not modified by demographic or anthropometric characteristics.
Assuntos
Hipertensão Intracraniana , Nervo Óptico , Humanos , Adulto , Feminino , Recém-Nascido , Colômbia/epidemiologia , Estudos Prospectivos , Nervo Óptico/diagnóstico por imagem , Hipertensão Intracraniana/diagnóstico , Voluntários Saudáveis , Ultrassonografia/métodos , Pressão Intracraniana/fisiologiaRESUMO
In this paper a 14-years-old Colombian native horse is reported, which was submitted by the presence of a mass in the foreskin region (20 x 20 cm) which blocked the passage of urine. Histopathological analysis of the biopsy of the mass revealed a squamous cell carcinoma. Tumor progression, and its size increased area increasingly committed which complicated surgical resection. Subsequently, the animal showed progressive decay, and the caregiver decided compassionate euthanasia. Histopathological analysis of samples taken at necropsy revealed pulmonary metastases of the foreskin neoplasia with peribronchial distribution.
En el presente trabajo se reporta el caso de un equino de raza criollo Colombiano de 14 años, que se remitió por la presencia de una masa en la región prepucial (20 x 20 cm) la cual obstruía el paso de la orina. El análisis histopatológico de la biopsia de la masa evidenció un carcinoma de células escamosa. La evolución del tumor, y su incremento del tamaño comprometió cada vez más área lo cual complico la resección quirúrgica. Posteriormente, el animal presentó decaimiento progresivo, y el cuidador decidió la eutanasia compasiva. El análisis histopatológico de las muestras tomadas a la necropsia evidenció metástasis pulmonar de la neoplasia prepucial, con distribución peribronquial.
No presente trabalho é reportado o caso de um eqüino de raça local Colombiana de 14 anos, que foi remitido por presença de uma massa na região prepucial (20 x 20 cm) a qual impedia o passo da urina. A análise histopatológica da biopsia da massa evidenciou um carcinoma de células escamoso. A evolução do tumor, e seu incremento do tamanho comprometeu cada vez mais a área o qual complicou a ressecção cirúrgica. Posteriormente, o animal apresentou decaimento progressivo, e o cuidador decidiu a eutanásia compassiva. A análise histopatológica das amostras tomadas à necropsia evidenciou metástase pulmonar da neoplasia prepucial, com distribuição Peri bronquial.