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1.
Am J Dermatopathol ; 44(9): 669-674, 2022 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-35503889

RESUMO

ABSTRACT: Oral cavity is not a common route for metastatic dissemination; metastasis to the oral region may affect soft tissues and jawbones, accounting for approximately 1% of all oral malignant neoplasms. The diagnosis of metastatic lesions to the oral cavity is usually challenging to clinicians and pathologists because of their complexity and rarity. We present a series of 12 metastatic neoplasms to the oral cavity that were detected previously or after the diagnosis of the primary tumor. All tumors were of epithelial origin with primary sites in the esophagus (2 cases), colon (2 cases), bladder, lungs, liver, larynx, skin, uterus, prostate, and adrenal gland, each with one case. The commonest site of the metastatic masses in the oral cavity was the gingiva, frequently presented as a vegetating, friable mass. The clinical examination and histopathologic analysis of the lesions were central to establishing the final diagnosis of the tumors. Metastatic masses to the oral cavity should always be considered as differential diagnosis of benign-looking lesions, especially in patients with previous history of a malignant disease. Biopsy is mandatory to establish an accurate diagnosis.


Assuntos
Neoplasias Bucais , Diagnóstico Diferencial , Feminino , Humanos , Masculino , Neoplasias Bucais/patologia
2.
Am J Dermatopathol ; 35(2): 248-51, 2013 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-23249835

RESUMO

Oral mucosal melanoma is rare. Its incidence peaks between 41 and 60 years of age; male/female ratio is 2:1. Preferred oral sites include hard palate and maxillary gingiva. Risk factors have not been clearly identified, but pigmented lesions may be present before the diagnosis of oral melanoma. We report an unusual case of oral mucosal melanoma of long-standing duration on hard palate and maxillary alveolar ridge in a male patient. Histopathologic features confirmed the diagnosis of invasive melanoma with a prominent in situ component. A cell lineage derived from the tumor was established and characterized, with phenotypic markers of melanocytes.


Assuntos
Linhagem Celular Tumoral , Melanoma/patologia , Neoplasias Bucais/patologia , Idoso , Humanos , Masculino , Mucosa Bucal/patologia , Palato Duro/patologia
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