RESUMO

Phenotype and gene frequencies among Atacameño Indians are presented for nine serum protein polymorphisms (Hp, Gc with subtypes, Tf with subtypes, Amy, C3, Bf, PLG) and nine red-cell-enzyme polymorphisms (AcP, PGM1 with subtypes, AK, ADA, 6-PGD, GPT, EsD, GLO). Four systems--Tf, Amy, AK, ADA were found to be monomorphic. In the PGM1 subtypes an extremely high frequency of PGM1a3 could be observed. In two samples a new Gc mutant was identified and classified as Gc1A26. In the EsD system an unusual phenotype was detected in one sample.

Assuntos

Proteínas Sanguíneas/genética , Enzimas/genética , Indígenas Sul-Americanos , Polimorfismo Genético , Adulto , Criança , Chile , Eritrócitos/enzimologia , Frequência do Gene , Marcadores Genéticos , Humanos , Mutação , Fenótipo

RESUMO

Aldehyde dehydrogenase deficiency, N-acetyltransferase variation and the polymorphisms of alpha 1-antitrypsin, serum cholinesterase, paraoxonase, and delta-aminolevulinic acid dehydratase were investigated in 180 Atacameño Indians from the North of Chile. The genetic predisposition of these individuals for possible atypical reactions against environmental agents and drugs, as well as general implications of these findings, are discussed.

Assuntos

Indígenas Sul-Americanos , Isoenzimas/genética , Aldeído Oxirredutases/deficiência , Aldeído Oxirredutases/genética , Arildialquilfosfatase , Chile , Colinesterases/sangue , Colinesterases/genética , Frequência do Gene , Humanos , Isoenzimas/deficiência , Monoéster Fosfórico Hidrolases/genética , Sintase do Porfobilinogênio/genética , alfa 1-Antitripsina/genética