RESUMO
A method is described for the extraction and estimation of 17-ketosteroids and 17-ketogenic steroids in human urine suitable for use in the moderately well equipped hospital laboratory. Data obtained from normal persons of both African and European descent is presented together with examples from two clinical conditions in the diagnosis of which these assays are invaluable
Assuntos
Humanos , Adulto , Pessoa de Meia-Idade , Masculino , Feminino , 17-Cetosteroides/isolamento & purificação , Sistema Hipófise-Suprarrenal , 17-Cetosteroides/diagnósticoRESUMO
Evidence is presented from both the literature and personal observation supporting the thesis that adrenal cortical activity in the tropics is `abnormal' by existing standards. The current programme, designed to investigate the influence of the dominant variables (racial factors and environmental conditions), is outlined, with discussion of some preliminary trends (AU)
Assuntos
Humanos , Córtex Suprarrenal/anormalidades , Clima Tropical , Fatores EpidemiológicosRESUMO
The mean daily 17-ketosteroid excretion for a group of coloured Jamaicans was not found to be significantly different from that of Europeans living under the same conditions. Mean 17-ketogenic steroid excretion was significantly lower in the Jamaicans (Summary)