RESUMO
There are very few studies which have considered perception temporality when relating perceived intensity and hedonic responses in relation to body mass index (BMI; kg/cm2). The aim of the present study was to determine the relationship between BMI with the dynamic perception and liking of bitter tasting solutions. For this purpose, two different categories of bitter products were applied: 6-n-propilthiouracil (PROP) solutions (0.010, 0.032 and 0.060â¯mmol/L) and commercial beverages (coffee, yerba mate infusion and grapefruit juice). The proposed methodology to evaluate perception and hedonic response was based on the measurement of reaction-time (R-T) and multiple-sip time-intensity (T-I) registers in people with a high BMI (25â¯<â¯BMIâ¯<â¯30; overweight group) and a normal BMI (<25; normal-weight control group). The multiple-sip evaluation to describe perception of PROP solutions and liking of beverages was used as a more ecologically valid laboratory methodology to simulate a situation of usual consumption. In this sense, working with a multiple-sip design helped confirm that bitter taste has a cumulative effect since in every case the sip effect was significant when evaluating the maximum intensity; this effect was more important as the bitterness increased. Regarding the body weight group comparisons, the normal BMI group perceived bitter taste more intensely and the time to react to it was shorter (faster reaction) for both PROP solutions and the three beverages. Interestingly, even though the high BMI group rated the bitter taste as less intense, they had a lower level of acceptance than normal BMI. This result suggests that the hedonic rather than the sensory component might be playing a crucial role in the perception of bitter taste in individuals with high BMI.
Assuntos
Índice de Massa Corporal , Preferências Alimentares , Obesidade/parasitologia , Tempo de Reação , Percepção Gustatória , Paladar , Adolescente , Adulto , Café , Feminino , Sucos de Frutas e Vegetais , Humanos , Ilex paraguariensis , Masculino , Pessoa de Meia-Idade , Obesidade/fisiopatologia , Filosofia , Propiltiouracila/administração & dosagem , Fatores de Tempo , Adulto JovemRESUMO
El objetivo del presente es la caracterización de pacientes en terapia intensiva en el hospital de alta complejidad, y portadores de insuficiencia respiratoria aguda con requerimiento de asistencia ventilatoria mecánica, a su vez, el comportamiento de pacientes con infección por el virus influenza H1N1 que desarrollan síndrome de dificultad respiratorio agudo (SDRA).
Assuntos
Vírus da Influenza A , Síndrome do Desconforto Respiratório , Insuficiência Respiratória , Vírus da Influenza A Subtipo H1N1 , Unidades de Terapia IntensivaRESUMO
Introduction: Low back pain (LBP) is a prevalent condition, which causes an important economic and clinical impact to individuals during their productive work-life. Electro-anaesthesia methods of choice are Interferential Current (IC) and transcutaneous Electric Nervous Stimulation (TENS). The objetive of this study is to determine the effectiveness of both therapies, as well as variability in the measurement of pain. We also preliminary evaluate the comparative effectiveness of IC and TENS by determining the mean difference of decreased acute back pain in patients treated at Hospital of Trabajador, in Temuco, Chile. Material and Method: 30 LBP patients were studied (0-3 weeks evolution). Intensity of pain before and after the aplication of IC and TENS was assessed usin the Visual Analogue Scale (VAS). IC intervention considered an amploitude.frequency spectrum ranging from 5 Hz to 10 Hz, with vector, while TENS was an asymmetric biphasic stimulus with a phase time of 150 useg, using a frequency of 100 Hz, pulses of 2 Hz. These were applied using four rubber electrodes (60 mm by 40 mm) placed on the lumbar zone for a period of 30 minutes. Results: The study group included 67 por ciento (n = 20) male with an average age of 38.3 years (SD: 9.5 years), 67 por ciento of them were workmen. The reduction of pain mean difference in patients treated with TENS was 1.24 cm (p = 0005), and 2.18 cm (p = 0001) with IC. The difference of both results, adjusted by VAS baseline, age, sex, and occupation of patients was 0.91 cm (p = 0.0261) in favour of IC. Conclusions: The magnitude of treatment effects for TENS was 18.4 por ciento, and 31.5 por ciento for IC in relation to baseline pain. In this study group, there were no clinically relevant differences to control LBP in patients inmediately after application, between IC and TENS. Both demonstrated to be effective.
Assuntos
Humanos , Dor Lombar/diagnóstico , Dor Lombar/fisiopatologia , Dor Lombar/terapia , Estimulação Elétrica Nervosa Transcutânea/métodos , Estimulação Elétrica Nervosa Transcutânea/tendências , Estimulação Elétrica Nervosa Transcutânea , Analgesia/instrumentação , Analgesia/métodos , Analgesia , Chile , Modalidades de FisioterapiaRESUMO
A serological survey for HTLV infection identified an AIDS patient with HTLV-I/HTLV-II dual seroreactivity. Two further sequential blood samples were collected (samples A and B) for PCR, restriction fragment length polymorphism (RFLP), and sequence analyses of HTLV-I and HTLV-II strains. PCR analyses confirmed dual infection in both samples. Restriction digests of the env region amplified from sample A showed the presence of an HTLV-IIa subtype; the HTLV-II provirus was found to be defective in the pol and env regions in the second sample from this patient. RFLP analysis of the HTLV-II LTR region of both samples confirmed this finding and identified an a5/bzl restriction type. Nucleotide sequence analyses revealed full homology in the HTLV-I env and LTR regions and in the HTLV-II LTR region between the two samples. These findings document the first case of an HTLV-I/HTLV-II coinfection that was fully confirmed and characterized by means of molecular analyses.
Assuntos
Síndrome da Imunodeficiência Adquirida/complicações , Infecções por HTLV-I/complicações , Infecções por HTLV-II/complicações , Adulto , Brasil , Infecções por HTLV-I/virologia , Infecções por HTLV-II/virologia , Vírus Linfotrópico T Tipo 1 Humano/genética , Vírus Linfotrópico T Tipo 1 Humano/isolamento & purificação , Vírus Linfotrópico T Tipo 2 Humano/genética , Vírus Linfotrópico T Tipo 2 Humano/isolamento & purificação , Humanos , Masculino , Dados de Sequência Molecular , Reação em Cadeia da Polimerase , Polimorfismo de Fragmento de Restrição , Análise de Sequência de DNARESUMO
BACKGROUND: Limited data suggest that Puerto Ricans experience greater disability than other ethnic groups, but few studies have examined the factors associated with this apparent difference. METHODS: We describe the prevalence of functional limitation and disability in a representative sample of Puerto Rican and Dominican elders in Massachusetts, and in a neighborhood comparison group of non-Hispanic whites (NHWs). We then relate disability scores, based on both prevalence and severity of ADL or IADL limitation, with self-reported history of diagnosed health conditions--adjusting for age, sex, body mass index (BMI; weight kg/height m(2)), income, education, living alone, smoking, and alcohol use. RESULTS: Seventy-five percent of Dominican women and 73% of Puerto Rican women reported difficulty with at least one ADL, compared with 64% of NHW women. Puerto Rican men reported significantly more limitation than did NHW or Dominican men. Conditions significantly associated with at least two disability measures among the NHW included smoking, former heavy alcohol use, arthritis, cataract, respiratory disease, and high BMI, but not stroke, diabetes, history of heart attack, or depression. The patterns for Puerto Ricans differed, with the strongest associations between disability and stroke, arthritis, diabetes, and depression, followed by history of heart attack, high BMI, cataract, poverty status, and respiratory disease. Only arthritis and depression were consistently significantly associated with disability among this smaller sample of Dominican elders. CONCLUSIONS: Functional limitation and disability are more prevalent among Puerto Ricans and among Dominican women than among neighborhood NHWs in Massachusetts. Greater disability is associated with the presence of chronic health conditions, which differ by ethnic group. Additional research is needed to further define the social and health factors that contribute to these ethnic differences.
Assuntos
Atividades Cotidianas , Pessoas com Deficiência , Nível de Saúde , Hispânico ou Latino , População Branca , Fatores Etários , Idoso , Consumo de Bebidas Alcoólicas/etnologia , Índice de Massa Corporal , Doença Crônica , Doença/classificação , Doença/etnologia , República Dominicana/etnologia , Escolaridade , Família , Feminino , Humanos , Renda , Masculino , Massachusetts , Prevalência , Porto Rico/etnologia , Fatores Sexuais , Fumar/etnologiaRESUMO
To study issues of diet and health among Hispanic adults living in the northeastern United States, the authors adapted a version of the National Cancer Institute (NCI)/Block food frequency questionnaire. Foods that contributed to nutrient intake of Puerto Rican adults in the Hispanic Health and Nutrition Examination Survey (HHANES) were ranked to identify items to be added to the food list. Portion sizes were compared across HHANES and the Second National Health and Nutrition Examination Survey (NHANES II) to assess the adequacy of the assumed values. Within line items, frequencies of consumption of individual foods were ranked and these data were used to adjust the weighting factors within the database. To test the revised form, 24-hour recalls were collected from 90 elderly Hispanics and 35 elderly non-Hispanic whites. These data were coded into the original and revised food frequency forms and nutrient intake results were compared with recall results by paired t-test, and by Pearson and intraclass correlations. Added foods include plantains, avocado, mango, cassava, empanadas, and custard. Portion sizes differed significantly between HHANES and NHANES II, and were left open-ended. Estimated mean nutrient intakes and correlations with recall data were lower with the original versus the revised form. The authors conclude that the use in minority populations of food frequency questionnaires developed for the general population is likely to result in biased estimates of intake unless modifications are made in the questionnaires.
Assuntos
Inquéritos Nutricionais , Idoso , Métodos Epidemiológicos , Feminino , Alimentos , Hispânico ou Latino , Humanos , Masculino , Pessoa de Meia-Idade , Porto Rico , Inquéritos e Questionários , População BrancaRESUMO
We investigated the presence of human T-cell lymphotropic virus types I and II (HTLV-I and HTLV-II) infections, first searching for specific antibodies in 553 serum samples obtained from HIV-1-infected patients from São Paulo, Brazil. Sera were screened using two enzyme-linked immunosorbent assays (ELISAs): the ELISA-EM (ELISA HTLV-I/II, EMBRABIO, BR), which contains HTLV-I and HTLV-II lysates, and the ELISA-DB [ELISA HTLV-I/II, Diagnostic Biotechnology (DB), Singapore], which contains HTLV-I lysate, and HTLV-I and HTLV-II recombinant env proteins (MTA-1 and K55, respectively). Serum samples showing two positive and/or borderline results were confirmed by Western blot (WB 2.3, DB), which discriminates HTLV-I from HTLV-II. WB analyses disclosed 22 cases (4.0%) of HTLV-I and 34 (6.1%) of HTLV-II seroreactivity; 24 sera had indeterminate antibody profile (4.3%) and 2 specimens showed reactivity to both MTA-1 and K55 env proteins. Using stringent WB criteria and analyzing the population according to risk factors, the prevalence rates of HTLV-I and HTLV-II infections were 11.2% and 16.8% in i.v. drug users, 3.4% and 5.5% in heterosexual individuals, and 1.4% and 2.2% in homosexual/bisexual men, respectively. A comparison of ELISA and WB results disclosed that both ELISAs were highly sensitive in detecting HTLV-I antibodies, whereas the ELISA-DB showed 82% sensitivity and the ELISA-EM 100% sensitivity in detecting HTLV-II antibodies. PCR analyses conducted on 37 representative cells samples confirmed the presence of HTLV proviral DNA in the majority of concordant serological cases, except in one, which was HTLV-I infected and seroreacted with K55 protein of HTLV-II. Indeed, after PCR, one case of HTLV-I infection and HTLV-II coinfection, and 30% of WB-seroindeterminate or inconclusive cases infected with HTLV-II could be detected. Our data stress high prevalences of both HTLV-I and HTLV-II infections in HIV-1 coinfected i.v. drug users from São Paulo, and suggests that ELISA kits containing only K55 protein as the HTLV-II-specific antigen, may not have the appropriate sensitivity for the detection of HTLV-II infection in this geographic region, pointing out the need of improved screening tests to be used in Brazil.
Assuntos
Western Blotting/métodos , DNA Viral/isolamento & purificação , Ensaio de Imunoadsorção Enzimática/métodos , Infecções por HIV/complicações , Vírus Linfotrópico T Tipo 1 Humano/isolamento & purificação , Vírus Linfotrópico T Tipo 2 Humano/isolamento & purificação , Adolescente , Adulto , Idoso , Brasil/epidemiologia , Feminino , Anticorpos Anti-HTLV-I/sangue , Antígenos HTLV-I , Anticorpos Anti-HTLV-II/sangue , Antígenos HTLV-II , Vírus Linfotrópico T Tipo 1 Humano/genética , Vírus Linfotrópico T Tipo 1 Humano/imunologia , Vírus Linfotrópico T Tipo 2 Humano/genética , Vírus Linfotrópico T Tipo 2 Humano/imunologia , Humanos , Masculino , Pessoa de Meia-Idade , Prevalência , Fatores de Risco , Sensibilidade e EspecificidadeRESUMO
To explore the possible involvement of herpes virus (KSHV) in AIDS-associated Kaposi's sarcoma (KS) in 7 patients in Brazil, we analyzed 7 AIDS-KS lesions. Using PCR, we found KSHV specific sequences in 3 cases and by using nested PCR, we identified sequences in each of the 7 cases. Direct sequencing on nested-PCR products showed a certain degree of variability in relation to classic KSHV sequences, and identified alterations similar to those described in some endemic cases from Africa and in AIDS-associated KS specimens from North America. This mixed pattern of KSHV sequences observed in AIDS-associated KS from Brazil may reflect the geographic origin of the samples, consistent with the environmental and epidemiological backgrounds of people in this country. It is apparent that, just as in other countries in the world, Kaposi's sarcoma in HIV patients is related to herpes virus infection.
RESUMO
To estimate the presence of, and the risk factors for HTLV-I and HTLV-II infections among HIV-1 infected subjects in Sao Paulo, Brazil, a serosurvey was performed in 471 HIV-1 infected patients, including 216 intravenous drug addicts (IVDA), 229 homosexual/bisexual men, and 26 with other risk factors. Serum samples were screened for HTLV seroreactivity by ELISA; reactive samples were analyzed by Western Blot (WB), using whole HTLV-I lysate as antigen. To confirm and discriminate HTLV-I and HTLV-II infections, sera presenting any bands on WB were further analyzed by a WB containing recombinant HTLV-I and HTLV-II proteins (WB 2.3), and by enzyme immunoassays using synthetic peptides specific for envelope proteins (Synth-EIA). In 22 cases, cell samples were available for polymerase chain reaction (PCR) studies. On WB, 114 sera were reactive and, of these, 37 and 25 were concordantly positive on both WB 2.3 and Synth-EIA procedures for HTLV-I and HTLV-II specific antibodies, respectively; 37 specimens were negative on both assays, and 15 gave discordant or indeterminate results. PCR findings confirmed concordant results obtained in the discriminatory serological assays. The prevalence rates of HTLV-I and HTLV-II infections were 15.3% and 11.1% in IVDA, and 0.9% and 0.4% in homosexual/bisexual men, respectively. No case of HTLV-I/HTLV-II co-infection was found.
PIP: HTLV-I is associated with adult T-cell leukemia/lymphoma and a neurological disorder known as HTLV-I-associated myelopathy or tropical spastic paraparesis. HTLV-II was initially isolated from subjects with a T-cell variant of hairy cell leukemia, but its etiological role in that or other diseases is unclear. HTLV infections, like HIV, are transmitted sexually, via blood transfusion and contaminated needles, and from mother to infant. Many reports indicate that HTLVs are present in the same populations at risk for HIV-1, and the cofactorial role of HTLVs in AIDS progression has been suggested by in vitro studies and epidemiological data. The authors report findings from a serosurvey conducted among 216 HIV-seropositive male and female intravenous drug users (IVDU), 229 HIV-seropositive homosexual and bisexual men, and 7 HIV-seropositive men and women who had had multiple transfusions, and 19 HIV-seropositive heterosexual men with multiple partners to estimate the presence of and the risk factors for HTLV-I and HTLV-II infections among HIV-1 infected individuals in Sao Paulo, Brazil. 70.9% of the subjects were classified according to CDC criteria as having AIDS. ELISA, Western blot, and polymerase chain reaction methods were used. The prevalence rates of HTLV-I and HTLV-II infections were 15.3% and 11.1% in IVDUs, and 0.9% and 0.4% in homosexual and bisexual men, respectively. No case of HTLV-I/HTLV-II co-infection was observed.
Assuntos
Soropositividade para HIV/complicações , HIV-1 , Infecções por HTLV-I/complicações , Infecções por HTLV-I/epidemiologia , Infecções por HTLV-II/complicações , Infecções por HTLV-II/epidemiologia , Vigilância da População , População Urbana , Adolescente , Adulto , Idoso , Bissexualidade , Western Blotting , Brasil/epidemiologia , Comorbidade , Ensaio de Imunoadsorção Enzimática , Feminino , Infecções por HTLV-I/sangue , Infecções por HTLV-II/sangue , Homossexualidade Masculina , Humanos , Técnicas Imunoenzimáticas , Masculino , Pessoa de Meia-Idade , Reação em Cadeia da Polimerase , Prevalência , Fatores de Risco , Estudos Soroepidemiológicos , Abuso de Substâncias por Via Intravenosa/complicaçõesRESUMO
In a series of 97 infants born to mothers who were seropositive for human immunodeficiency virus type 1 (HIV-1), 18 were identified as infected within the first 60 days of life on the basis of viral culture and polymerase chain reaction findings. We studied viral burden in vivo by quantitative polymerase chain reaction and the in vitro replication pattern of the HIV-1 infecting strain by culturing patient cells with normal phytohemagglutinin-stimulated peripheral blood mononuclear cells. According to the lag phase before p24 antigen detection and the level of p24 production on peripheral blood mononuclear cells, HIV-1 isolates from these patients were classified as rapid/high (R/H), slow/high (S/H), and slow/low (S/L). The pattern of HIV-1 replication in vitro was significantly associated with the viral burden in vivo; the range of HIV-1 copies per 10(5) peripheral blood mononuclear cells was 10 to 38, 44 to 314, and 360 to 947 in children with isolates of the S/L, S/H, and R/H types, respectively. Viral tropism was assessed by culturing patient cells under end-point dilution conditions with either CD4+ T-lymphocytes or monocyte-derived macrophages. We found that children with S/L isolates harbored mainly monocytotropic variants; all infants with S/H or R/H isolates had T-lymphotropic variants and, in 7 of 11 cases, monocytotropic or amphitropic variants. All children with R/H isolates had HIV-related symptoms by the age of 4 months, and five had acquired immunodeficiency syndrome by the age of 1 year. At 1 year of age, four and no infants with S/H or S/L isolates, respectively, had HIV-1-related symptoms (p < 0.001), and none had acquired immunodeficiency syndrome (p = 0.006).
Assuntos
Infecções por HIV/congênito , Infecções por HIV/fisiopatologia , HIV-1/fisiologia , Linfócitos T CD4-Positivos , Pré-Escolar , Proteína do Núcleo p24 do HIV/análise , Infecções por HIV/diagnóstico , Infecções por HIV/imunologia , HIV-1/isolamento & purificação , Humanos , Lactente , Recém-Nascido , Reação em Cadeia da Polimerase , Prognóstico , Replicação ViralRESUMO
A 54 years old white woman and a 38 years old white man with short-bowel disease are reported. Both of them were submitted to surgical procedures for urinary oxalate calculi. They presented malabsorption syndrome with steatorrhea and severe malnutrition. The patients received parenteral nutrition. The woman had also cholelithiasis and acute pancreatitis. The clinical and laboratory data are presented and the pathophysiology of short-bowel disease with emphasis on bile salts depletion, the effect of bile salts on colon oxalate absorption, and intestinal loss of water is commented. The management of short-bowel disease and the use of cholesteramine and the supplementary diet is discussed.
Assuntos
Síndromes de Malabsorção/fisiopatologia , Oxalatos/metabolismo , Síndrome do Intestino Curto/fisiopatologia , Adulto , Ácidos e Sais Biliares/metabolismo , Colo/metabolismo , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Síndrome do Intestino Curto/metabolismoRESUMO
En un estudio retrospectivo de tres años (julio de 1983 a junio de 1986), se analizan todos los casos de eclampsia ocurridos en el Hospital Paula Jaraquemada, de la ciudad de Santiago de Chile. En un total de 32.729 partos, hubo 29 eclampsias, con una incidencia de 0,89%, es decir, una eclampsia cada 1.128 partos. 62% de nuestras pacientes eran nulíparas;37%, menores de 19 años;55% eran solteras, y 28 de las enfermas tuvieron asistencia prenatal. 62% presentó la crisis convulsiva en el preparto, y con respecto a la edad de gestación, 55% eran de pretérmino. En 11 de las pacientes la crisis se presentó fuera del recinto hospitalario. Todas las pacientes fueron tratadas con terapia anticonvulsiva con sulfato de magnesio, y en algunas se agregó Diazepam endovenoso. Se usó hidralazina como droga hipotensora. La resolución del parto fue mediante cesárea en 86,2%, y la anestesia general se dió en un 55%. La interrupción del embarazo fue dentro de las 12 primeras horas después de iniciadas las crisis convulsivas. La morbalidad materna fue de 31%; desprendimiento prematuro de placenta ocurrió en cuatro casos. Se consignan, además, dos casos de insuficiencia renal aguda, uno de neumonía aspirativa y dos de edema cerebral. No hubo mortalidad materna. Con respecto a los neonatos, cabe considerar que hubo un embarazo gemelar, por lo cual los recién nacidos fueron 30. Hubo una alta incidencia de recién nacidos de pretérmino (43,3%);recién nacidos de bajo peso (36,6%), pequeños para la edad de gestación (26,6%). Asimismo, hubo una alta morbilidad perinatal (53,3%), lo cual se atribuye a la prematuridad, retardo de crecimiento intrauterino, sufrimiento fetal agudo. Sólo un recién nacido falleció. La mortalidad perinatal fue de 33%. Estos resultados, tanto de mortalidad materna como perinatal, son los mejores publicados en nuestro país
Assuntos
Adolescente , Adulto , Humanos , Feminino , Eclampsia/epidemiologia , Mortalidade Materna , Mortalidade Perinatal , Estudos RetrospectivosRESUMO
Se realizó un estudio prospectivo durante 4 años de cepas de estreptococos "viridans" o no agrupables. Se estudiaron 100 cepas clínicamente significativas aisladas de hemocultivos (dos o más muestras) y de otros materiales clínicos (cuando se visualizaban al exame directo, en presencia de reacción inflamatória). Cincuenta y ocho cepas fueron identificadas con 10 reacciones bioquímicas y en 42 fue necesario realizar determinaciones adicionales. Solamente 16 cepas resultaron no identificables. Los setreptococos aislados correspondieron a infecciones piógenas (53%) (en especial S. milleri y S. mitior); endocarditis (27%) (S.bovis I. S. sanguis, S. mutans y S. bovis II); infecciones urinarias (10%) (S. bovis II, S. milleri)
Assuntos
Humanos , Endocardite Bacteriana/microbiologia , Técnicas In Vitro , Streptococcus/isolamento & purificação , Infecções Urinárias/microbiologiaRESUMO
Se realizó un estudio prospectivo durante 4 años de cepas de estreptococos "viridans" o no agrupables. Se estudiaron 100 cepas clínicamente significativas aisladas de hemocultivos (dos o más muestras) y de otros materiales clínicos (cuando se visualizaban al exame directo, en presencia de reacción inflamatória). Cincuenta y ocho cepas fueron identificadas con 10 reacciones bioquímicas y en 42 fue necesario realizar determinaciones adicionales. Solamente 16 cepas resultaron no identificables. Los setreptococos aislados correspondieron a infecciones piógenas (53%) (en especial S. milleri y S. mitior); endocarditis (27%) (S.bovis I. S. sanguis, S. mutans y S. bovis II); infecciones urinarias (10%) (S. bovis II, S. milleri) (AU)
Assuntos
Humanos , Técnicas In Vitro , Streptococcus/isolamento & purificação , Endocardite Bacteriana/microbiologia , Infecções Urinárias/microbiologiaRESUMO
In a 4 year prospective study of "viridans" or non-groupable streptococci 100 clinically significant strains were isolated. Strains were defined as significant when found in two or more samples of blood cultures, or when seen on Gram staining together with inflammatory reaction. Fifty-two strains were speciated by 10 physiological characteristics. In 42 cases additional tests were performed. Only 16 isolates were unidentifiable by the techniques used. Sources of isolates included purulent lesions (53%) (mainly S. milleri and S. mitior); endocarditis (27%) (S. bovis I, S. sanguis, S. mutans, S. bovis II) and urinary tract infections (10%) (S. bovis II, S. milleri).
Assuntos
Infecções Estreptocócicas/microbiologia , Streptococcus/classificação , Endocardite Bacteriana/microbiologia , Humanos , Estudos Prospectivos , Streptococcus/isolamento & purificaçãoRESUMO
Se estudiaron los niveles séricos de aminoglucósidos y cloramfenicol en 67 enfermos con infecciones severas. Se realizaron 114 determinaciones mediante el método microbiológico. El control interno de calidad demonstró una exactitud (límite de confiabilidad 95%) de 22,4%. Los resultados obtenidos indujeron a modificar la dosis unitaria en 29 casos y el intervalo de administración en 12 enfermos. En total, de 61,2% de los enfermos requirieron modificaciones en la posología pese al uso de un monogramo y/o programa de ajuste de dosis (Hewlett-Packard 01784D y 01785D