RESUMO
Infection of the upper respiratory tract is a major cause of morbidity and mortality in patients with lymphoproliferative syndromes and multiple myeloma. Nebulizations with IgA tested in a randomized double blind trial to evaluate its efficacy to prevent respiratory infections in patients with lymphoproliferative syndromes and multiple myeloma. Forty nine patients were evaluated (chronic lymphocytic leukaemia, 22; multiple myeloma, 11; lymphoma, 8; HCL, 6; Waldenström and lymphoepiteliod tymoma, 1 patient each) were randomized to receive nebulizations every 12 hours during 3 months of IgA or placebo. Seven infectious episodes (4 respiratory tract infections) in 25 IgA treated patients and 25 episodes (16 respiratory tract infections) in 24 control patients were recorded (p <0.0002). Eighteen patients belonging to the treated group remained free of infections against only 5 from the control group (p < 0.001). No difference related to the grade of infections was observed between groups. The arithmetic media for the first infection observed in each group was 45.6 +/- 22.0 days for the IgA treated and 28.6 +/- 17.5 days for the placebo (p < 0.025). According to this study, IgA nebulization therapy was useful to prevent respiratory tract infections and also delay the onset of infection in patients with lymphoproliferative syndromes and myeloma.
Assuntos
Imunoglobulina A/uso terapêutico , Controle de Infecções/métodos , Transtornos Linfoproliferativos/complicações , Mieloma Múltiplo/complicações , Administração Intranasal , Aerossóis , Idoso , Infecções Oculares/complicações , Infecções Oculares/epidemiologia , Infecções Oculares/prevenção & controle , Feminino , Gastroenterite/complicações , Gastroenterite/epidemiologia , Gastroenterite/prevenção & controle , Humanos , Hospedeiro Imunocomprometido , Imunoglobulina A/administração & dosagem , Masculino , Nebulizadores e Vaporizadores , Infecções Respiratórias/complicações , Infecções Respiratórias/epidemiologia , Infecções Respiratórias/prevenção & controle , Dermatopatias Infecciosas/complicações , Dermatopatias Infecciosas/epidemiologia , Dermatopatias Infecciosas/prevenção & controle , Resultado do Tratamento , Infecções Urinárias/complicações , Infecções Urinárias/epidemiologia , Infecções Urinárias/prevenção & controleRESUMO
The recently described monocytoid B-cell lymphoma is a low-grade lymphoma presenting most frequently in elderly women and commonly associated with autoimmune diseases. Leukaemic expression of this disease has been reported in advanced stages. A case of monocytoid lymphocytosis without lymph node enlargement is presented herein. A 60-year old woman complaining of easy bruises was found to have a 2-cm splenomegaly. Her laboratory data included the following: haemoglobin, 125 g/L; haematocrit, 0.35 L/L; white cell count, 29 x 10(9)/L with 32% PMN, 3% stabs, 2% myelocytes, 1% metamyelocytes, 30% lymphocytes and 32% atypical mononucleated cells showing wide, pale cytoplasm neatly contoured and oval nucleus with monocytoid features. The basal coagulation study showed prothrombin 50%, APTT 40 seconds, fibrinogen 68 mg/dL and FDP between 80 and 160 ng/dL. Splenomegaly without lymph-node enlargement was found on CT scan. The bone-marrow biopsy showed a 68% monocytoid lymphocytic infiltration, acid-phosphatase positive and tartrate-sensitive, without fibrosis. Bone-marrow and peripheral immunophenotype showed those cells to be CD22, CD 19 and CD11 positive, while T and CD25 markers were absent. The patient was treated with alpha-2b interferon at a dose of 3MU three times a week for 6 months, with general improvement and regression of the leukaemic expression. Eleven months after diagnosis she died of a central nervous system haemorrhage. The morphological, immunological and cytochemical features of the monocytoid lymphocytes in this case are commented, along with their variable behaviour. A review of the literature is also carried out, attention being laid on the onset and the response to therapy of B-cell monocytoid lymphomas as the singularity of this case lies on its exclusively leukaemic onset. It is concluded that an interrelationship between monocytoid B-lymphocytic leukaemia and B-cell monocytoid lymphoma might possibly exist, such as that between chronic lymphocytic leukaemia and diffuse lymphocytic lymphoma.
Assuntos
Leucemia de Células B , Medula Óssea/patologia , Feminino , Humanos , Fatores Imunológicos/uso terapêutico , Imunofenotipagem , Interferon alfa-2 , Interferon-alfa/uso terapêutico , Leucemia de Células B/complicações , Leucemia de Células B/patologia , Leucemia de Células B/terapia , Pessoa de Meia-Idade , Células-Tronco Neoplásicas/imunologia , Células-Tronco Neoplásicas/patologia , Púrpura/etiologia , Proteínas Recombinantes , Esplenomegalia/etiologia , Resultado do TratamentoRESUMO
The effectiveness of a commercial drug containing fibrinogen, thrombin and factor XIL (Tissucol, Immuno) was assessed in 127 patients receiving oral anticoagulant treatment with acenocoumarin who were subjected to 183 minor surgical procedures: 107 exodontia, 53 periodontal procedures, 17 combinations of the former, 4 liver biopsies and 2 skin biopsies. All but the liver biopsies were performed in the outpatient clinic. Mild haemorrhage appeared in 21 instances. None of the patients required systemic administration of coagulation factors, and the maneuvers did not take any longer than in patients with integrity of the coagulation mechanisms. The outstanding benefits of this technique are: less discomfort for patients, who can be subjected to a single procedure while otherwise requiring several sessions; anticoagulation needs not be discontinued, subcutaneous heparin being otherwise necessary; low risk of complications and avoidance of substitutive therapy; lesser economic burden, as no hospital admission is needed.
Assuntos
Acenocumarol/efeitos adversos , Biópsia/efeitos adversos , Adesivo Tecidual de Fibrina/uso terapêutico , Hemorragia/prevenção & controle , Transtornos Hemorrágicos/induzido quimicamente , Hemostasia Cirúrgica/métodos , Periodontia , Extração Dentária/efeitos adversos , Adulto , Idoso , Procedimentos Cirúrgicos Ambulatórios , Avaliação de Medicamentos , Feminino , Transtornos Hemorrágicos/tratamento farmacológico , Humanos , Fígado/patologia , Masculino , Pessoa de Meia-Idade , Segurança , Pele/patologiaRESUMO
Presentamos una leucemia monoblástica aguda con múltiples infiltrados dérmicos específicos iniciales rebeldes a la quimioterapia, hematológicamente eficaz. Insistimos en la necesidad de diagnosticar (impronta) y evaluar la magnitud de los mismos con fines diagnósticos (biopsia), así como en la detección de posibles santuarios cutáneos, para lo cual la inmunomarcación de muramidasa resultó de gran valor
Assuntos
Adolescente , Humanos , Masculino , Leucemia Monocítica Aguda/patologia , Biópsia , Leucemia Monocítica Aguda/tratamento farmacológico , Muramidase/uso terapêuticoRESUMO
Presentamos una leucemia monoblástica aguda con múltiples infiltrados dérmicos específicos iniciales rebeldes a la quimioterapia, hematológicamente eficaz. Insistimos en la necesidad de diagnosticar (impronta) y evaluar la magnitud de los mismos con fines diagnósticos (biopsia), así como en la detección de posibles santuarios cutáneos, para lo cual la inmunomarcación de muramidasa resultó de gran valor (AU)
Assuntos
Adolescente , Humanos , Masculino , Leucemia Monocítica Aguda/patologia , Biópsia , Leucemia Monocítica Aguda/tratamento farmacológico , Muramidase/uso terapêuticoRESUMO
Utilizando el metodo inmunohistoquimico de anticuerpos libres peroxidasa-antiperoxidasa, se realizo la caracterizacion de inmunoglobulinas intracitoplasmaticas, en material de biopsia de medula osea incluida en parafina de once pacientes portadores de mieloma multiple. Se obtuvo franca correlacion entre la inmunomarcacion plasmocitaria y el componente "M" serico, demostrandose la eficacia de la tecnica a pesar de los procedimientos agresivos que sufre el tejido medular para su procesamiento histologico. Esta marcacion inmunologica realza su valor en los casos de plasmocitomas no secretores, o con bajo componente plasmocitario proliferante y el diagnostico diferencial de plasmocitosis reactivas, al ser altamente especifica para la demonstracion de mono o policlonalidad celular
Assuntos
Humanos , Técnicas Imunoenzimáticas , Imunoglobulinas , Mieloma MúltiploRESUMO
Utilizando el metodo inmunohistoquimico de anticuerpos libres peroxidasa-antiperoxidasa, se realizo la caracterizacion de inmunoglobulinas intracitoplasmaticas, en material de biopsia de medula osea incluida en parafina de once pacientes portadores de mieloma multiple. Se obtuvo franca correlacion entre la inmunomarcacion plasmocitaria y el componente "M" serico, demostrandose la eficacia de la tecnica a pesar de los procedimientos agresivos que sufre el tejido medular para su procesamiento histologico. Esta marcacion inmunologica realza su valor en los casos de plasmocitomas no secretores, o con bajo componente plasmocitario proliferante y el diagnostico diferencial de plasmocitosis reactivas, al ser altamente especifica para la demonstracion de mono o policlonalidad celular