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1.
J Sports Med Phys Fitness ; 57(7-8): 1051-1056, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-27433932

RESUMO

BACKGROUND: There is a lack of information regarding the positive effects of different types of physical training on HIV-positive patient immune function, body composition and physical fitness. The goal of this study was two-fold: 1) to determine the effects of a three-month progressive strength training program on lymphocyte CD4+ cell counts in HIV-positive patients; and 2) to measure strength improvements, body composition and cardiovascular alterations in HIV-positive patients after a strength training program. METHODS: Sixteen HIV-positive male subjects participated in a strength-training program. CD4+ cell count, heart rate body composition and strength measurements were acquired at rest two days before and two days after the program. RESULTS: The average CD4+ cell count was increased (%=23%, P=0.0005), and all strength tests also showed improvement (%=95%, P=0,0001). Patient resting heart rate decreased (%=9%, P=0.0042), as did the skinfold sum (%=16%, P=0.002). Limb circumference sum and body weight did not change. CONCLUSIONS: Considering that a decrease in CD4+ cell count, muscle mass and overall physical fitness are expected results of HIV infection, the strength training protocol described here is an effective and safe way to improve immune function, body composition and cardiovascular fitness in HIV-positive patients. The results provided an important evidence for the effectiveness of a 3-month progressive resistance exercise training program at increasing immune function and physical fitness, strongly recommending its inclusion in the standardized treatment plan of HIV-positive patients.


Assuntos
Composição Corporal/fisiologia , Soropositividade para HIV/imunologia , Soropositividade para HIV/fisiopatologia , Frequência Cardíaca/fisiologia , Força Muscular/fisiologia , Treinamento Resistido/métodos , Adulto , Peso Corporal , Contagem de Linfócito CD4 , Exercício Físico/fisiologia , Humanos , Linfócitos , Masculino , Pessoa de Meia-Idade , Aptidão Física/fisiologia
2.
J Int Soc Sports Nutr ; 9(1): 30, 2012 Jun 26.
Artigo em Inglês | MEDLINE | ID: mdl-22734448

RESUMO

BACKGROUND: Exercise is an excellent tool to study the interactions between metabolic stress and the immune system. Specifically, high-intensity exercises both produce transient hyperammonemia and influence the distribution of white blood cells. Carbohydrates and glutamine and arginine supplementation were previously shown to effectively modulate ammonia levels during exercise. In this study, we used a short-duration, high-intensity exercise together with a low carbohydrate diet to induce a hyperammonemia state and better understand how arginine influences both ammonemia and the distribution of leukocytes in the blood. METHODS: Brazilian Jiu-Jitsu practitioners (men, n = 39) volunteered for this study. The subjects followed a low-carbohydrate diet for four days before the trials and received either arginine supplementation (100 mg·kg-1 of body mass·day-1) or a placebo. The intergroup statistical significance was calculated by a one-way analysis of variance, followed by Student's t-test. The data correlations were calculated using Pearson's test. RESULTS: In the control group, ammonemia increased during matches at almost twice the rate of the arginine group (25 mmol·L-1·min-1 and 13 µmol·L-1·min-1, respectively). Exercise induced an increase in leukocytes of approximately 75%. An even greater difference was observed in the lymphocyte count, which increased 2.2-fold in the control group; this increase was partially prevented by arginine supplementation. The shape of the ammonemia curve suggests that arginine helps prevent increases in ammonia levels. CONCLUSIONS: These data indicate that increases in lymphocytes and ammonia are simultaneously reduced by arginine supplementation. We propose that increased serum lymphocytes could be related to changes in ammonemia and ammonia metabolism.

3.
Appl Physiol Nutr Metab ; 37(2): 334-44, 2012 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-22458821

RESUMO

We compared the effects of 12 weeks of 3 different exercise types on type 2 diabetic (T2DM) male and female human subjects, randomly divided into 4 groups: aerobic training (AT; n = 11), strength training (ST; n = 10), combined training (CBT; n = 10), and no training (NT; n = 12). Metabolic control, anthropometric parameters, lipid and hematological profiles, kidney and liver function markers, hormones, antioxidant enzymes, and oxidative stress markers were assessed prior to and after the training programs. At baseline, fasting blood glucose and hemoglobin A(1c) in the ST group were higher than in the NT group; after the training, we no longer observed differences in these groups, suggesting an improvement on these parameters. In the AT group, catalase and superoxide dismutase activity, nitrite concentration, levels of sulfhydryl groups, and peak rate of oxygen consumption were elevated after the training (p < 0.05). No changes were observed in antioxidant enzymes or oxidative stress markers in the ST group. The levels of sulfhydryl groups diminished in the NT group (p < 0.01) and increased in the CBT group (p < 0.05). These data demonstrate that the AT program for the T2DM subjects provided important upregulation in antioxidant enzymes and increased nitric oxide bioavailability, which may help minimize oxidative stress and the development of the chronic complications of diabetes. We propose that the beneficial effects observed in the metabolic parameters of the ST group occurred in response to the poor baseline metabolic health n this group, and not necessarily in response to the training itself.


Assuntos
Antioxidantes/metabolismo , Diabetes Mellitus Tipo 2/terapia , Exercício Físico/fisiologia , Estresse Oxidativo/fisiologia , Adulto , Idoso , Biomarcadores/sangue , Glicemia/análise , Composição Corporal , Catalase/sangue , Diabetes Mellitus Tipo 2/sangue , Feminino , Humanos , Rim/metabolismo , Peroxidação de Lipídeos/fisiologia , Fígado/metabolismo , Masculino , Pessoa de Meia-Idade , Músculo Esquelético/metabolismo , Nitritos/sangue , Consumo de Oxigênio , Espécies Reativas de Oxigênio/metabolismo , Superóxido Dismutase/sangue
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