RESUMO
PURPOSE: To assess and compare the prevalence of medication nonadherence (MNA) (implementation and persistence) to immunosuppressants and co-medications in heart transplant recipients. METHODS: MNA prevalence was assessed using the Basel Assessment of Adherence to Immunosuppressive Medications Scale (self-report) and compared using logistic regression in a 4-continent sample of 1397 heart transplant recipients from 36 heart transplant centers in 11 countries. FINDINGS: MNA was significantly (a » 0.05) higher to co-medications than to immunosuppressants (taking nonadherence: 23.9% vs 17.3%; odds ratio [OR] » 1.5; 95% CI, 1.30e1.73; drug holiday: 5.7% vs 1.9%; OR » 3.17; 95% CI, 2.13e4.73; dose alteration: 3.8% vs 1.6%; OR » 2.46; 95% CI, 1.49e4.06; and discontinuation: 2.6% vs 0.5%; OR » 5.15; 95% CI, 2.36e11.20).