RESUMO
Oral squamous cell carcinoma (SCC) is a malignant epithelial tumor that is uncommon in individuals younger than 45 years. This study compared the cell proliferation and angiogenic index in SCCs of the tongue between young and older patients. Forty SCCs of the tongue, 20 diagnosed in young patients (≤ 40 y) and 20 diagnosed in older patients (>50 y) were evaluated by immunohistochemistry. Cell proliferation was evaluated using the Ki-67 labeling index (LI). The angiogenic index was determined by microvessel count (MVC) using anti- von Willebrand factor antibody. The mean Ki-67 LI in SCCs of the tongue was 43.8% (range, 26.0% to 72.4%) in young patients and 42.5% (range, 9.0% to 59.4%) in older patients (P=0.968). No significant difference in the Ki-67 LI was observed in relation to clinical stage or histologic grade of malignancy in either group (P>0.05). The mean MVC in SCCs of the tongue was 24.3 (range, 8.6 to 51.6) in young patients and 25.6 (range, 5.4 to 42.4) in older patients (P=0.543). There was no significant difference in MVC in relation to clinical stage or histologic grade of malignancy in either group (P>0.05). In addition, no significant correlation was observed between the Ki-67 LI and the angiogenic index (P>0.05). The results of this study suggest that the more aggressive biological behavior of SCC of the tongue in young patients may not be related to a higher cell proliferation rate or a higher angiogenic index.
Assuntos
Biomarcadores Tumorais/genética , Carcinoma de Células Escamosas , Antígeno Ki-67/genética , Neoplasias da Língua , Língua/irrigação sanguínea , Fator de von Willebrand/genética , Adolescente , Adulto , Fatores Etários , Idoso , Carcinoma de Células Escamosas/irrigação sanguínea , Carcinoma de Células Escamosas/diagnóstico , Carcinoma de Células Escamosas/patologia , Proliferação de Células , Feminino , Expressão Gênica , Humanos , Imuno-Histoquímica , Masculino , Microvasos/patologia , Pessoa de Meia-Idade , Estadiamento de Neoplasias , Neovascularização Patológica , Prognóstico , Língua/patologia , Neoplasias da Língua/irrigação sanguínea , Neoplasias da Língua/diagnóstico , Neoplasias da Língua/patologiaRESUMO
PURPOSE: The purpose of this study was to retrospectively analyze the clinical, demographic, and pathologic properties of oral pyogenic granuloma occurring in a Brazilian population. PATIENTS AND METHODS: We retrieved an archival number of 293 cases that were diagnosed as having oral pyogenic granuloma at the Service of Pathological Anatomy, Discipline of Oral Pathology, Department of Dentistry, Federal University of Rio Grande do Norte, Natal, Brazil, during a 38-year period, from 1970 to 2008. The records were reviewed, and information on gender, age, race, lesion site, predisposing factors, clinical features, and clinical diagnosis, treatment, and recurrence was collected. RESULTS: There was a female predilection, and the female-to-male ratio was 2.38:1. The mean age of the patients was 27 years. A high degree of occurrence was observed in the second decade of life. White patients were most commonly affected (44.7%). The most frequently involved site was the gingiva (83%), with a higher prevalence in the maxilla. The majority of cases were symptomatic and showed bleeding; the lesions were described as nodules (71.9%) with a soft consistency (62.3%) and a red surface (73.2%). The base was pedunculated in 61.1% of cases, and the mean size was 1.3 cm. The recurrence rate was 8.2% of cases. CONCLUSION: The clinical, demographic, and pathologic features of oral pyogenic granuloma in the Brazilian population in this study were similar to those in studies of populations from other countries.
Assuntos
Doenças da Gengiva/patologia , Granuloma Piogênico/patologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Brasil , Criança , Pré-Escolar , Feminino , Humanos , Lactente , Masculino , Pessoa de Meia-Idade , Mucosa Bucal/patologia , Estudos Retrospectivos , Razão de Masculinidade , Adulto JovemRESUMO
A lesão central de células gigantes (LCCG) é considerada uma lesão rara de natureza proliferativa, de etiologia e patogenia desconhecidas. Ocorre mais em região de mandíbula e no gênero feminino. Este artigo relata um caso de LCCG em uma paciente do gênero feminino, 30 anos, melanoderma, e aborda aspectos atuais desta lesão, no tocante ao comportamento clínico, etiopatogenia e tratamento.
The central giant cell granuloma (CGCG) is regarded as a rare proliferative lesion of unknown etiology and pathogenesis. It occurs frequently in the jaw region and in females. This article reports a case of CGCG in a female patient, 30 years-old, black and addresses current aspects of this lesion with regard to clinical behavior, pathogenesis and treatment.
Assuntos
Humanos , Feminino , Adulto , Radiografia Panorâmica , Mandíbula , Cirurgia Bucal , Granuloma de Células GigantesRESUMO
Esta revisão de literatura contempla a afirmativa de que a prática odontológica é definitivamente dependente de um bom diagnóstico e de uma boa aplicação dos materiais dentários. Diante de tal afirmação, o profissional que atua na área de restauradora deve conhecer a evolução das resinas compostas de uso direto desde o seu primórdio até o estágio atual, para que se possibilite o entendimento da performance de restaurações com este material, observando-se fatores como resistência, estética e função. Da mesma forma, o conhecimento das propriedades intrínsecas dos materiais permite que o Cirurgião-dentista utilize-os com maior segurança