RESUMO
We present the results obtained with a ureterovesical implant after ipsilateral ureteral obstruction in the rat, suitable for the study of renal function after deobstruction in these animals. Thirty-seven male Wistar rats weighing 260 to 300 g were submitted to distal right ureteral ligation and divided into 3 groups, A (N = 13, 1 week of obstruction), B (N = 14, 2 weeks of obstruction) and C (N = 10, 3 weeks of obstruction). The animals were then submitted to ureterovesical implantation on the right side and nephrectomy on the left side. During the 4-week follow-up period serum levels of urea and creatinine were measured on the 2nd, 7th, 14th, 21st and 28th day and compared with preoperative levels. The ureterovesical implantation included a psoas hitch procedure and the ureter was pulled into the bladder using a transvesical suture. During the first week of the postoperative period 8 animals died, 4/13 in group A (1 week of obstruction) and 4/14 in group B (2 weeks of obstruction). When compared to preoperative serum levels, urea and creatinine showed a significant increase (P < 0.05) on the 2nd postoperative day in groups A and B, with a gradual return to lower levels. However, the values in group B animals were higher than those in group A at the end of the follow-up. In group C, 2/10 animals (after 3 weeks of obstruction) were sacrificed at the time of ureterovesical implantation due to infection of the obstructed kidneys. The remaining animals in this group were operated upon but all of them died during the first week of follow-up due to renal failure. This technique of ureterovesical implantation in the rat provides effective drainage of the upper urinary tract, permitting the development of an experimental model for the study of long-term renal function after a period of ureteral obstruction.
Assuntos
Modelos Animais de Doenças , Testes de Função Renal/métodos , Obstrução Ureteral/fisiopatologia , Animais , Masculino , Ratos , Ratos Wistar , Fatores de TempoRESUMO
OBJECTIVE: In this report we assessed the results obtained with cutaneous vesicostomy for the temporary diversion of urine in small children. PATIENTS AND METHODS: We analyzed the medical records of 20 patients (17 boys and 3 girls) that underwent this type of diversion at our institution. Cutaneous vesicostomy was done due to severe hydronephrosis with low renal function and/or urinary tract infection with metabolic acidosis. RESULTS: The urinary tract anomalies were posterior urethral valves in 12 children, vesicoureteral reflux in 7 and anterior urethral valve in one. Elevated levels of serum urea and creatinine were found in 16 patients during pre-operative evaluation. During the follow-up there was a reduction of hydronephrosis in all patients, and 5 progressed to chronic renal failure. These patients had worse development of weight and body lenght when compared to those with normal renal function. The post-operative complications were prolapse in 2 patients and stenosis of the stoma in 2. CONCLUSION: cutaneous vesicostomy has proved to be an useful form of urinary diversion. In our experience it is an effective and easily reversible temporary treatment for infants and children with severe hydronephrosis associated with urinary tract infection due to infravesical obstruction or vesicoureteral reflux.
RESUMO
We present the results obtained with a ureterovesical implant after ipsilateral ureteral obstruction in the rat, suitable for the study of renal function after deobstruction in these animals. Thirty-seven male Wistar rats weighing 260 to 300 g were submitted to distal right ureteral ligation and divided into 3 groups, A (N = 13, 1 week of obstruction), B (N = 14,2 weeks of obstruction) and C (N = 10, 3 weeks of obstruction). The animals were then submitted to ureterovesical implantation on the right side and nephrectomy on the left side. During the 4-week follow-up period serum levels of urea and creatinine were measured on the 2nd, 7 th, 14th, 21st and 28th day and compared with preoperative levels. The ureterovesical implantation included a psoas hitch procedure and the ureter was pulled into the bladder using a transvesical suture. During the first week of the postoperative period 8 animals died, 4/13 in group A (1 week of obstruction) and 4/14 in group B (2 weeks of obstruction). When compared to preoperative serum levels, urea and creatinine showed a significant increase (P<0.05) on the 2nd postoperative day in groups A and B, with a gradual return to lower levels. However, the values in group B animals were higher than those in group A at the end of the follow-up. In group C,2/10 animals (after 3 weeks of obstruction) were sacrificed at the time of ureterovesical implantation due to infection of the obstructed kidneys. The remaining animals in this group were operated upon but all of them died during the first week of follow-up due to renal failure. This technique of ureterovesical implantation in the rat provides effective drainage of the upper urinary tract, permitting the development of an experimental model for the study of long-term renal function after period of ureteral obstruction.
Assuntos
Ratos , Animais , Masculino , Modelos Animais de Doenças , Testes de Função Renal/métodos , Obstrução Ureteral/fisiopatologia , Doenças Urológicas/fisiopatologia , Ratos WistarRESUMO
Spermatic cord torsion is an urologic emergency that requires urgent evaluation and possibly emergency surgical management. In a neonate it occurs during testicular descent and is usually due to an extravaginal torsion, where the testis and sperinatic cord twist. We present a case of intravaginal testicular torsion in a neonate. In this situation, as the anomalous implant of the tunica vaginalis can occur bilaterally, it is important to fix the contralateral testis in order to prevent late torsion of this gonad.