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Ann Plast Surg ; 68(1): 22-8, 2012 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-21659848

RESUMO

BACKGROUND: Pathologic skin scarring reversion remains a big challenge for surgeons, as disfiguring scars have a dramatic influence on patient's quality of life. METHODS: A controlled clinical trial was conducted to evaluate 8% pirfenidone (PFD) gel administered topically 3 times a day during 6 months to 33 pediatric patients with hypertrophic scars caused by burns. A total of 30 patients with hypertrophic scars with identical Vancouver Scar Scale values were treated with pressure therapy and included as controls. Improvements were evaluated by Vancouver Scar Scale and a Visual Analog Scale. Safety parameters were determined by the presence of adverse events and monitoring laboratory and hematology parameters. RESULTS: Patients treated with PFD during 6 months presented a continuous monthly statistically significant scar regression in comparison with the initial Vancouver measurement (P = <0.001). PFD group showed a higher improvement of all scar features as compared with control group treated with pressure therapy (P = <0.001). In the PFD group, 9 of 33 patients (27%) had their scores decreased in Vancouver classification by more than 55%, 22 patients (67%) had a 30% to 45% decrease, whereas 2 patients (6%) had a 30% decrease or less. Control group treated with pressure therapy showed a slight improvement in 16% of cases on an average. Patients did not show serious adverse effects or laboratory alterations throughout the study. CONCLUSIONS: Topical administration of 8% PFD gel 3 times a day is more effective and safe in the treatment of hypertrophic scars caused by burns in children, as compared with standard pressure therapy.


Assuntos
Anti-Inflamatórios não Esteroides/uso terapêutico , Queimaduras/complicações , Cicatriz Hipertrófica/tratamento farmacológico , Bandagens Compressivas , Piridonas/uso terapêutico , Administração Cutânea , Adolescente , Criança , Pré-Escolar , Cicatriz Hipertrófica/etiologia , Cicatriz Hipertrófica/terapia , Esquema de Medicação , Feminino , Géis , Humanos , Masculino , Projetos Piloto , Estudos Prospectivos , Resultado do Tratamento
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