RESUMO

(-)-Hinokinin (1) is a dibenzylbutyrolactone lignan obtained by the partial synthesis of (-)-cubebin. This study reports the antigenotoxic and anticarcinogenic potential of 1 by the comet and aberrant crypt focus assays in the peripheral blood and colon of 4-5-week-old Wistar rats, respectively. The rats were exposed to 1,2-dimethylhydrazine (40 mg/kg) and were treated by gavage with doses of 10, 20, and 40 mg/kg of 1. The results showed that the dose of 40 mg/kg was neither genotoxic nor carcinogenic. In the comet assay, all 1 doses displayed antigenotoxic effects. In addition, this compound (20 and 40 mg/kg) exhibited an anticarcinogenic effect in the aberrant crypt focus assay.

Assuntos

1,2-Dimetilidrazina/farmacologia , 4-Butirolactona/análogos & derivados , Dioxóis/farmacologia , Lignanas/farmacologia , 4-Butirolactona/química , 4-Butirolactona/farmacologia , Animais , Anticarcinógenos/farmacologia , Benzodioxóis , Carcinógenos/farmacologia , Colo/efeitos dos fármacos , Ensaio Cometa , Dano ao DNA/efeitos dos fármacos , Dimetilidrazinas/química , Dioxóis/química , Lignanas/química , Masculino , Estrutura Molecular , Piper/química , Ratos , Ratos Wistar , Estereoisomerismo