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J Agric Food Chem ; 64(9): 1899-909, 2016 Mar 09.
Artigo em Inglês | MEDLINE | ID: mdl-26872073

RESUMO

Seventeen polyphenols (e.g, apigenin, genistein, and luteolin glycosides) and 11 lipophilic compounds (e.g., fatty acids, sterols, and terpenes) were detected by LC-MS/MS-ESI and GC-MS, respectively, in Jatropha platyphylla. Extracts from pulp, kernel, and leaves and fractions were studied to know their effect on some pro-inflammatory mediators. Phenolic and lipophilic extracts showed significant inhibitory effects on ROS and NO production while not affecting mitochondrial activity or superoxide generation rate in lipopolysaccharide (LPS)-induced inflammation in RAW 264.7 macrophage cells. In addition, NO production was also diminished by lipophilic leaf fractions F1 and F2 with the latter fraction showing a greater effect and composed mainly of sterols and terpene. Furthermore, total extracts showed nonselective inhibitions against cyclooxygenase COX-1 and COX-2 activities. All together, these results suggest that J. platyphylla extracts have potential in treating inflammatory diseases and their activity is mediated by flavonoids and lipophilic compounds.


Assuntos
Anti-Inflamatórios/farmacologia , Flavonoides/farmacologia , Jatropha/química , Lipopolissacarídeos/farmacologia , Macrófagos/efeitos dos fármacos , Animais , Inibidores de Ciclo-Oxigenase/farmacologia , Macrófagos/fisiologia , Camundongos , Óxido Nítrico/biossíntese , Fitoterapia , Extratos Vegetais/química , Extratos Vegetais/farmacologia , Células RAW 264.7 , Espécies Reativas de Oxigênio/metabolismo , Esteróis/farmacologia , Terpenos/farmacologia
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