RESUMO
The prevalence of antibodies to cytomegalovirus (CMV) was determined by the indirect enzyme-linked immunosorbent assay in a selected population of 2655 in Jamaica. The overall prevalence rate was 95 percent, increasing from 56.2 percent in children 1-4 years of age to 90 percent in the 15-19 years age group and by 25 years of age 97 percent of subjects had been exposed to CMV. The prevalence rate in children (58.4 percent) was significantly lower than that in blood donors (84 percent), sexually transmitted disease clinic attendants (95 percent) and antenatal women (97 percent) (P< 0.001). The prevalence rate in STD clinic attendants and pregnant women was also significantly higher than in blood donors (P< 0.05). The prevalence of CMV infection in the selected population, the clinical implications, routes of transmission and socioenvironmental factors are discussed (AU)
Assuntos
Humanos , Gravidez , Recém-Nascido , Lactente , Pré-Escolar , Criança , Adolescente , Feminino , Citomegalovirus , Ensaio de Imunoadsorção Enzimática , Testes Sorológicos , Fatores Socioeconômicos , Anticorpos Antivirais/sangueRESUMO
Seroprevalence of toxoplasma gondii, rubella virus, cytomegalovirus, herpes simplex virus infections (TORCH) and syphilis were determined in order to assess the immune/susceptibility status in Jamaican pregnant women in 1986. The positive rates were 57 percent (T. gondii), 69 percent (rubella), 97percent (CMV), 91 percent (HSV), and 4.9 percent (syphilis), respectively. The rate of reactivity for rubella was over 50 percent in all parishes, the highest being 85 percent in St. Thomas. The seroprevalence of T. gondii was lowest in Trelawny (37.5 percent). There were no significant differences in seropositivity of CMV and HSV infections between women from various parishes. The importance of seroprevalence of the TORCH group of agents and syphilis on perinatal morbidity and mortality in Jamaican women is discussed, and appropriate recommendations for prevention and control of congenital infections in Jamaica are suggested. (AU)
Assuntos
Humanos , Adolescente , Adulto , Feminino , Gravidez , Toxoplasma/imunologia , Vírus da Rubéola/imunologia , Citomegalovirus/imunologia , Simplexvirus/imunologia , Sífilis/imunologia , Sorodiagnóstico da Sífilis , Testes Sorológicos , Anticorpos Antiprotozoários , Anticorpos Antivirais , Toxoplasmose Congênita/prevenção & controle , Sífilis Congênita/prevenção & controle , Síndrome da Rubéola Congênita/prevenção & controle , JamaicaRESUMO
Five hundred and four patients with suspected genital herpes simplex virus (HSV) infection were investigated in Jamaica between 1982 and 1984. Of these, 100 (19.8 percent) were virologically confirmed. There were 12 patients with primary/first episode, 45 recurrent and 6 "provoked' type of genital herpes simplex virus infections. Genital herpes in women was more severe than in men. Eighty-eight per cent of genital herpes was confirmed by virus isolation. Forty HSV isolates were identified as HSV type 2. There was a sero-response in 75 percent primary, 18 percent recurrent and 17 percent provoked type of genital herpes. Virus isolation is the most sensitive and specific test for the diagnosis of genital herpes simplex virus infection. The measurement of serum anti herpes simplex complement-fixing antibodies was not useful in the diagnosis of suspected patients with genital ulcers and their contacts. The infectiousness of the virus, clinical manifestations, complications such as neonatal herpes infections, psychosocial problems and methods of prevention are issues that clinicians should discuss with patients with genital herpes (AU)
Assuntos
Adulto , Feminino , Humanos , Masculino , Herpes Genital/epidemiologia , Herpes Genital/diagnóstico , Simplexvirus/classificação , Sorotipagem , JamaicaRESUMO
The prevalence of genital herpes simplex infection is unknown in Jamaica and in other Caribbean countries. From November 1982 to October 1984, 504 patients with suspected genital herpes simplex virus infection were investigated in Jamaica. Of these 100 (19.8 percent) were virologically confirmed. The confirmation rate was 21.3 percent in patients attending the sexually transmitted disease clinic and 16.8 percent of patients referred from private practitioners. Of the virologically confirmed cases, there were 12 patients with primary/first episode, 45 recurrent and 6 provoked type of genital herpes simplex virus infection. In 35 patients, the type was unknown. Symptoms of genital herpes were more severe in women than men. Genital herpes in women was accompanied by systematic symptoms (53 percent), local pain (70 percent), itching (46 percent) and genital ulcers (100 percent). There was a serological response in 75 percent primary, 18 percent recurrent and 17 percent provoked type of genital herpes simplex infections. Twenty herpes virus isolates were identified as Herpes simplex type 2 by indirect immunofluorescent antibody test. No Herpes simplex type I isolates were made. Virus isolation is the most sensitive and specific test for the diagnosis of genital herpes simplex virus infection. The measurement of serum anti-herpes simplex complement fixing antibodies was not useful in the diagnosis of suspected genital ulcer patients and their contacts. The presence of genital herpes in Jamaica should alert clinicians to the possibility of unrecognised neonatal Herpes infections and aseptic meningitis (AU)