RESUMO
This paper presents CA2JU, a hardware/software tool that aims to help individuals with severe speech or language problems in their communication in order to promote their social and digital inclusion. CA2JU is composed of two applications: CA2JU Accelerated, which makes typing faster by suggesting potential words to the user; and CA2JU Illustrated, which automatically converts a sentence of words into a sequence of pictographic symbols, allowing a user familiar with the symbols to verify whether the written sentence is correct. We have implemented, evaluated in a controlled scenario, and deployed CA2JU in a real environment with children with cerebral palsy. In the controlled settings, the results confirm CA2JU Accelerated speed up typing by reducing the number of clicks made by users, and CA2JU Illustrated obtained high accuracy by suggesting the correct pictograms from sentences. In the real scenario, the two use cases show that the children improved their communication and linguistic abilities.
Assuntos
Paralisia Cerebral/prevenção & controle , Auxiliares de Comunicação para Pessoas com Deficiência , Periféricos de Computador , Software , Interface Usuário-Computador , Processamento de Texto/métodos , Brasil , Criança , Pré-Escolar , Desenho de Equipamento , Análise de Falha de Equipamento , Humanos , Masculino , Processamento de Texto/instrumentaçãoRESUMO
Molecular plant components have long been aimed at the angiogenesis and anti-angiogenesis pathways, and have been tested as sources for antineoplasic drugs with promising success. The present work deals with the anti-angiogenic effects of Methyl Jasmonate. Jasmonate derivatives were demonstrated to selectively damage the mitochondria of cancer cells. In vitro, 1-10 mM Methyl Jasmonate induced the cell death of the human umbilical vein endothelial cells (HUVEC) and the Murine melanoma cells (B16F10), while micromolar concentrations were ineffective. In vivo, comparable concentrations were toxic and reduced the vessel density of the Chorioallantoic Membrane of the Chicken Embryo (CAM). However, 1-10 microM concentrations produced a complex effect. There was increased capillary budding, but the new vessels were leakier and less organised than corresponding controls. It is suggested that not only direct toxicity, but also the drug effects upon angiogenesis are relevant to the antineoplasic effects of Methyl Jasmonate.