RESUMO
Introducción. El limitar la longitud de la extirpación (stripping) de la vena safena mayor al segmento insuficiente con base en los hallazgos de la ecografía Doppler a color, permite disminuir la morbilidad. Materiales y métodos. Se llevó a cabo un estudio prospectivo y aleatorio de 155 pacientes intervenidos durante 24 meses, de los cuales 74 fueron sometidos a una safenectomía corta y 81 a una safenectomía larga. Las variables evaluadas durante el seguimiento fueron: tipo de anestesia, porcentaje de atención ambulatoria, morbilidad quirúrgica, días de incapacidad temporal y recidivas varicosas. Los síntomas de afectación neurológica ligados a la safenectomía se evaluaron de forma temprana y a largo plazo. Resultados. El 91,6 % de los enfermos fueron intervenidos de forma ambulatoria, con un período de incapacidad temporal menor de tres semanas y 18 % de recidivas. El costo unitario de las intervenciones concertadas con el Sistema Público de Salud fue inferior a USD$ 950. La safenectomía corta tuvo mejores resultados que la larga en casi todos los parámetros estudiados, con menos días de ausencia laboral (18,2 Vs. 22,6; p=0,013), morbilidad (14,9 % Vs. 33,3 %; p=0,036) y secuelas neurológicas a la finalización del estudio (2 % Vs. 11,9 %; p=0,043). Discusión. La safenectomía clásica es una técnica útil, con excelentes resultados clínicos y estéticos, escasas complicaciones y bajo costo. En ausencia de insuficiencia distal del eje safeno, la safenectomía corta es de elección por su menor morbilidad
Background: Limited stripping from the great saphenous vein to the insufficient segment based on the Doppler color echography findings reduces morbidity. Material and methods: A prospective randomized study was conducted on 155 patients who underwent surgery over a 24 months period, of which 74 were subjected to limited saphenectomy and 81 to total saphenectomy. The monitored variables during the followed up were: type of anesthesia, percentage as ambulatory surgery, surgical morbidity, temporary disability days, and recurrent varicose veins. Symptoms of neurological disturbances linked to saphenectomy were evaluated early and also at long term followup. Results: 91.6% were operated on as outpatients, exhibiting shorter period of temporary disability (3 weeks) and 18% recurrence rate. The cost of the actions agreed with the Public Health System interventions tariff, less than $950 USD. The limited saphenectomy procedure appeared better than the total saphenectomy in almost all parameters studied, with fewer days of sick leave (18,2 vs 22,6 p=0.013), morbidity rate (14.9% vs 33.3% p=0.036), and neurological sequelae at completion of the study (2% vs 11.9% p=0.043). Discussion: The classical saphenectomy is a useful technique, with excellent clinical and cosmetic results, few complications and low cost. In the absence of distal saphenous insufficiency axis, the limited saphenectomy appears as the preferred procedure in view of its lower morbidity
Assuntos
Humanos , Veia Safena , Varizes , Procedimentos Cirúrgicos Vasculares , Insuficiência VenosaRESUMO
Objetivo: El infarto de miocardio es la causa más común de fallo cardíaco congestivo. El objetivo de este trabajo es evaluar, en el animal de experimentación, los efectos morfológicos e histológicos de la implantación de plasma autógeno rico en plaquetas en el corazón de ovejas previamente infartadas. Métodos: Se utilizaron 24 ovejas lacha hembras, en las que se produjo quirúrgicamente un infarto agudo de miocardio, mediante toracotomía izquierda y ligadura permanente de 2 arterias coronarias (primera y segunda diagonal). Tras la ligadura de las arterias coronarias 3 ovejas fallecieron por fibrilación ventricular. Pasadas 3 semanas de la ligadura coronaria, las ovejas fueron reoperadas por esternotomía media vertical. En 6 de ellas (grupo control) se inyectó suero fisiológico en la zona del infarto. En 15 se inyectó gel plaquetario. Todas las ovejas fueron sacrificadas a las 9 semanas de evolución de la segunda cirugía. Resultados: En los corazones tratados con plasma rico en factores de crecimiento (PRGF) destaca la neoformación vascular en los cortes de hematoxilina-eosina y de factor VIII, a diferencia de los no tratados. Conclusiones: La inyección de factores de crecimiento plaquetarios, PRGF, en el corazón de ovejas previamente infartadas favorece la mitogénesis y la angiogénesis. El uso de PRGF autógeno es sencillo y seguro, no provocando toxicidad ni desencadenando reacciones inmunológicas ni inflamatorias.
Objective: Myocardial infarction is the most common cause of congestive heart failure. The objective of this work is to evaluate, in experimental animals, morphological and histological effects of the implantation of autologous platelet-rich plasma in infarcted heart sheep. Methods: Twenty-four ewes were used, they were surgically infarcted through left thoracotomy and two coronary arteries were ligated (first and second diagonal). After coronary artery ligation three sheep died of ventricular fibrillation. Three weeks after coronary ligation, sheep were reoperated through median sternotomy. Normal saline solution was injected in the infarcted zone in 6 of them (control group) whereas platelet gel was injected in 15 of them. All sheep were euthanized at 9 weeks of evolution of the second surgery. Results: Noteworthy is the formation of new vessels in hematoxylin-eosin-stained sections and factor VIII in plasma rich in growth-factors (PRGF)-treated hearts. Conclusions: Injection of platelet growth factors, PRGF, in previously infarcted sheep hearts promotes mitogenesis and angiogenesis. The use of autologous PRGF is simple and safe, causing no toxicity or immune-inflammatory reactions.
Assuntos
Animais , Feminino , Infarto do Miocárdio/terapia , Plasma Rico em Plaquetas , Infarto do Miocárdio/patologia , OvinosRESUMO
OBJECTIVE: Myocardial infarction is the most common cause of congestive heart failure. The objective of this work is to evaluate, in experimental animals, morphological and histological effects of the implantation of autologous platelet-rich plasma in infarcted heart sheep. METHODS: Twenty-four ewes were used, they were surgically infarcted through left thoracotomy and two coronary arteries were ligated (first and second diagonal). After coronary artery ligation three sheep died of ventricular fibrillation. Three weeks after coronary ligation, sheep were reoperated through median sternotomy. Normal saline solution was injected in the infarcted zone in 6 of them (control group) whereas platelet gel was injected in 15 of them. All sheep were euthanized at 9 weeks of evolution of the second surgery. RESULTS: Noteworthy is the formation of new vessels in hematoxylin-eosin-stained sections and factor viii in plasma rich in growth-factors (PRGF)-treated hearts. CONCLUSIONS: Injection of platelet growth factors, PRGF, in previously infarcted sheep hearts promotes mitogenesis and angiogenesis. The use of autologous PRGF is simple and safe, causing no toxicity or immune-inflammatory reactions.