RESUMO
OBJECTIVE: The aim of this study was to develop an initial valid tool to measure attitudes toward cancer-related cognitive changes. SUBJECTS AND METHODS: After revising the literature, three main dimensions were hypothesized. Eight judges were contacted to obtain content validity evidence. A robust Exploratory Factor Analysis (EFA) was performed via a parallel analysis with an Unweighted Least Squares (ULS) estimator and polychoric correlations. The results were crossed with sociodemographic variables to find possible statistical differences and estimate the size effect. Analysis was performed in the software Factor and the statistical package R. RESULTS: A sample of 374 participants was obtained, involving oncology patients, their caregivers, and people from the general community. A statistical fit was found in two dimensions: Awareness and Judgments [root mean squared error of approximation (RMSEA) = 0.042, standardized root mean square residual (SRMR) = 0.02, comparative fit index (CFI) = 0.99, Tucker-Lewis index (TLI) = 0.98] with a moderate correlation between them (r = 0.612). Optimal reliability indices were obtained for the total scale and its dimensions. No real statistical difference was found between sociodemographic variables; the interpretation norms were established via the quartiles. CONCLUSIONS: The first attempt to measure the construct of interest was developed with two primary validity evidence based on the content and its internal structure. This instrument could help strengthen the prevention of cancer-related cognitive changes. More research is needed to adhere more valid evidence to the scale.
Assuntos
Oncologia , Neoplasias , Humanos , Colômbia , Reprodutibilidade dos Testes , Software , CogniçãoRESUMO
Injuries in the metatarsophalangeal joint complex of the hallux are seen with greater frequency in athletes, their importance lies in the functional limitation it generates. Early diagnosis and treatment can reduce the sequelae, however, the recognition of chronic lesions and with it the implementation of adequate therapeutic management generate improvements in quality of life. This document records a case of inveterate dislocation of the metatarsophalangeal joint of the hallux of more than one year of evolution with involvement of the intersesamoid ligament which was corrected with arthrodesis achieving immediate satisfactory results, in the medium and long term with the subsequent functional recovery and total reduction of pain.
Las lesiones en el complejo articular metatarsofalángico del hallux son vistas con mayor frecuencia en deportistas, su importancia radica en la limitación funcional que genera. El diagnóstico y tratamiento temprano puede disminuir las secuelas; sin embargo, el reconocimiento de lesiones crónicas y con ello la implementación del adecuado manejo terapéutico, generan mejoras en la calidad de vida. Se registra en este documento un caso de luxación inveterada de la articulación metatarsofalángica del hallux de más de un año de evolución con compromiso del ligamento intersesamoideo, la cual fue corregida con artrodesis, se lograron resultados satisfactorios inmediatos, a mediano y largo plazo con la posterior recuperación funcional y disminución total del dolor.
Assuntos
Hallux Valgus , Hallux , Articulação Metatarsofalângica , Artrodese , Humanos , Articulação Metatarsofalângica/diagnóstico por imagem , Articulação Metatarsofalângica/cirurgia , Qualidade de VidaRESUMO
Haemocyanins (Hcs) are copper-containing, respiratory proteins that occur in the haemolymph of many arthropod species. Here, we report the presence of Hcs in the chilopode Myriapoda, demonstrating that these proteins are more widespread among the Arthropoda than previously thought. The analysis of transcriptome of S. subspinipes subpinipes reveals the presence of two distinct subunits of Hc, where the signal peptide is present, and six of prophenoloxidase (PPO), where the signal peptide is absent, in the 75 kDa range. Size exclusion chromatography profiles indicate different quaternary organization for Hc of both species, which was corroborated by TEM analysis: S. viridicornis Hc is a 6 × 6-mer and S. subspinipes Hc is a 3 × 6-mer, which resembles the half-structure of the 6 × 6-mer but also includes the presence of phenoloxidases, since the 1 × 6-mer quaternary organization is commonly associated with hexamers of PPO. Studies with Chelicerata showed that PPO activity are exclusively associated with the Hcs. This study indicates that Scolopendra may have different proteins playing oxygen transport (Hc) and PO function, both following the hexameric oligomerization observed in Hcs.
Assuntos
Catecol Oxidase/metabolismo , Quilópodes/metabolismo , Precursores Enzimáticos/metabolismo , Hemocianinas/química , Hemocianinas/metabolismo , Análise de Sequência de DNA/métodos , Animais , Proteínas de Artrópodes/química , Proteínas de Artrópodes/genética , Proteínas de Artrópodes/metabolismo , Catecol Oxidase/química , Quilópodes/genética , Cromatografia em Gel , Precursores Enzimáticos/química , Regulação da Expressão Gênica , Hemocianinas/genética , Hemolinfa/metabolismo , Modelos Moleculares , Peso Molecular , Filogenia , Conformação Proteica , Multimerização ProteicaRESUMO
Haemocyanins (Hcs) are copper-containing, respiratory proteins that occur in the haemolymph of many arthropod species. Here, we report the presence of Hcs in the chilopode Myriapoda, demonstrating that these proteins are more widespread among the Arthropoda than previously thought. The analysis of transcriptome of S. subspinipes subpinipes reveals the presence of two distinct subunits of Hc, where the signal peptide is present, and six of prophenoloxidase (PPO), where the signal peptide is absent, in the 75 kDa range. Size exclusion chromatography profiles indicate different quaternary organization for Hc of both species, which was corroborated by TEM analysis: S. viridicornis Hc is a 6 × 6-mer and S. subspinipes Hc is a 3 × 6-mer, which resembles the half-structure of the 6 × 6-mer but also includes the presence of phenoloxidases, since the 1 × 6-mer quaternary organization is commonly associated with hexamers of PPO. Studies with Chelicerata showed that PPO activity are exclusively associated with the Hcs. This study indicates that Scolopendra may have different proteins playing oxygen transport (Hc) and PO function, both following the hexameric oligomerization observed in Hcs.
RESUMO
Ichthyc biodiversity of seagrass meadows from the Northwest coast of Cariaco Gulf , Venezuela. Seagrasses are highly productive coastal ecosystems with a high diversity and abundance of fishes, very important to support artisanal fisheries. We analyzed the fish community structure of Thalassia testudinum in the communities of Manzanillo (M) and La Brea (LB), Northwest coast of Cariaco Gulf, Venezuela. Samples were taken monthly (Nov. 2006-Oct. 2007) from each place, using a beach net. A total of 34 810 fishes were captured, grouped into 13 orders, 36 families and 83 species. In both areas (M and LB), the number of species was similar, but a variation in their abundance was found: a total of 55 species and 13 210 organisms for M, and 58 species and 21 600 organisms for LB. The most abundant species and those with the highest biomasses in both areas were: Nicholsina usta, Haemulon boschmae, H. steindachneri, Harengula jaguana, Halichoeres bivittatus and Hemiramphus brasiliensis. The occasional visitors were the most frequent community components with a 59%, the cyclical and permanent residents were represented by the 22% and 19%, respectively. The H’n average for M was of 1.71±0.64bits/ind., while for LB was of 1.95±0.51bits/ind. The diversity values were directly related to the evenness and inversely related to the dominance. The low values of similarity indexes among localities allow us to assert that these fish communities are dissimilar, because of the structure of each Thalassia meadow and their connectivity with other systems. Rev. Biol. Trop. 60 (2): 635-648. Epub 2012 June 01.
Los pastos marinos son ecosistemas costeros de alta productividad, con gran diversidad y abundancia de peces, la cual es aprovechada por pescadores artesanales. En este estudio se analizó la estructura comunitaria íctica de praderas de Thalassia testudinum en Manzanillo (M) y La Brea (LB), costa noroeste del Golfo de Cariaco, Venezuela. También, se realizaron muestreos mensuales (11-2006 al 10-2007), con la utilización de una red playera. Se capturaron 34 810 organismos agrupados en 13 órdenes, 36 familias y 83 especies. En ambas zonas, el número de especies fue similar, aunque el número de organismos vario, y se encontró para M un total de 55 especies y 13 210 organismos y para LB 58 especies y 21 600 organismos. Las especies más abundantes y de mayor biomasa en el área muestreada fueron: Nicholsina usta, Haemulon boschmae, H. steindachneri, Harengula jaguana, Halichoeres bivittatus y Hemiramphus brasiliensis. Los visitantes ocasionales fue el componente comunitario más frecuente con 59%, los cíclicos y los residentes permanentes obtuvieron 22 y 19%, respectivamente. En M la H’n fue de 1.71±0.64bits/ind; entretanto en LB fue 1.95±0.51bits/ind. Los valores de la diversidad estuvieron relacionados directamente con la equitabilidad e inversamente con la dominancia. Los bajos valores del índice de similaridad, entre localidades permite establecer que estas comunidades ícticas son disimiles, debido quizás a la estructuración de cada pradera de Thalassia y a la conectividad con otros sistemas.
Assuntos
Animais , Biodiversidade , Biomassa , Peixes/classificação , Hydrocharitaceae , Ecossistema , Pesqueiros , Densidade Demográfica , Água do Mar , VenezuelaRESUMO
Seagrasses are highly productive coastal ecosystems with a high diversity and abundance of fishes, very important to support artisanal fisheries. We analyzed the fish community structure of Thalassia testudinum in the communities of Manzanillo (M) and La Brea (LB), Northwest coast of Cariaco Gulf, Venezuela. Samples were taken monthly (Nov. 2006-Oct. 2007) from each place, using a beach net. A total of 34 810 fishes were captured, grouped into 13 orders, 36 families and 83 species. In both areas (M and LB), the number of species was similar, but a variation in their abundance was found: a total of 55 species and 13 210 organisms for M, and 58 species and 21 600 organisms for LB. The most abundant species and those with the highest biomasses in both areas were: Nicholsina usta, Haemulon boschmae, H. steindachneri, Harengula jaguana, Halichoeres bivittatus and Hemiramphus brasiliensis. The occasional visitors were the most frequent community components with a 59%, the cyclical and permanent residents were represented by the 22% and 19%, respectively. The H'n average for M was of 1.71+/-0.64bits/ind., while for LB was of 1.95+/-0.51bits/ind. The diversity values were directly related to the evenness and inversely related to the dominance. The low values of similarity indexes among localities allow us to assert that these fish communities are dissimilar, because of the structure of each Thalassia meadow and their connectivity with other systems.
Assuntos
Biodiversidade , Biomassa , Peixes/classificação , Hydrocharitaceae , Animais , Ecossistema , Pesqueiros , Densidade Demográfica , Água do Mar , VenezuelaRESUMO
Introducción: Los accidentes cerebrovasculares (ACV) durante la gestación son trastornos poco comunes pero poseen significativa morbilidad y mortalidad. El embarazo podría por sí mismo ser responsable de esta evolución. Por otra parte, algunos aspectos de esta patología son pobremente comprendidos. Objetivo: Describrir los ACV diagnosticados durante la gestación y relacionar sus características clínicas con el tipo de ACV (hemorrágico o isquémico). Material y métodos: Análisis retrospectivo de 12 pacientes embarazadas con diagnóstico de ACV por TAC cerebral y/o RMN. Resultados: Al momento del diagnóstico del ACV, todas las pacientes se encontraron cursando el tercer trimestre de gestación, fueron antepartum y se pudo diagnosticar un estado hipertensivo asociado a la gestación. Ocho pacientes tuvieron un ACV hemorrágico (7 intracerebrales y 1 intrarraquídeo cervical). En el grupo ACV hemorrágico, 4 fueron parietooccipitales, 3 frontales y 1 intrearraquídeo (al nivel de C4 y C7 y signos de disección de arteria vertebrobasilar en la RMN) y del grupo ACV isquémico, 3 fueron parietooccipitales y 1 frontal...(AU)
Assuntos
Humanos , Adolescente , Adulto , Feminino , Gravidez , Complicações Cardiovasculares na Gravidez/etiologia , Acidente Vascular Cerebral/diagnóstico , Hemorragia Cerebral/diagnóstico , Complicações Cardiovasculares na Gravidez/epidemiologia , Acidente Vascular Cerebral/classificação , Acidente Vascular Cerebral/etiologia , Período Pós-Parto , Hemorragia Cerebral/epidemiologia , Hemorragia Cerebral/etiologia , Pré-Eclâmpsia , Síndrome HELLP , Fatores de Risco , Pré-Eclâmpsia/complicações , Eclampsia/complicaçõesRESUMO
Introducción: Los accidentes cerebrovasculares (ACV) durante la gestación son trastornos poco comunes pero poseen significativa morbilidad y mortalidad. El embarazo podría por sí mismo ser responsable de esta evolución. Por otra parte, algunos aspectos de esta patología son pobremente comprendidos. Objetivo: Describrir los ACV diagnosticados durante la gestación y relacionar sus características clínicas con el tipo de ACV (hemorrágico o isquémico). Material y métodos: Análisis retrospectivo de 12 pacientes embarazadas con diagnóstico de ACV por TAC cerebral y/o RMN. Resultados: Al momento del diagnóstico del ACV, todas las pacientes se encontraron cursando el tercer trimestre de gestación, fueron antepartum y se pudo diagnosticar un estado hipertensivo asociado a la gestación. Ocho pacientes tuvieron un ACV hemorrágico (7 intracerebrales y 1 intrarraquídeo cervical). En el grupo ACV hemorrágico, 4 fueron parietooccipitales, 3 frontales y 1 intrearraquídeo (al nivel de C4 y C7 y signos de disección de arteria vertebrobasilar en la RMN) y del grupo ACV isquémico, 3 fueron parietooccipitales y 1 frontal...
Assuntos
Humanos , Adolescente , Adulto , Feminino , Gravidez , Hemorragia Cerebral , Complicações Cardiovasculares na Gravidez , Acidente Vascular Cerebral , Hemorragia Cerebral , Eclampsia , Síndrome HELLP , Período Pós-Parto , Pré-Eclâmpsia , Complicações Cardiovasculares na Gravidez , Fatores de Risco , Acidente Vascular CerebralAssuntos
Humanos , Masculino , Feminino , Pré-Escolar , Adolescente , Crescimento , Diabetes Mellitus Tipo 1 , Metabolismo , ArgentinaAssuntos
Humanos , Masculino , Feminino , Pré-Escolar , Adolescente , Diabetes Mellitus Tipo 1 , Crescimento , Metabolismo , ArgentinaRESUMO
Doce pacientes con fibrosis endomiócardica, con comprobación angiográfica y/o histológica, fueron estudiados mediante ecocardiografía Doppler con el propósito de describir las características ecocardiográficas e identificar los sitios de afección. La edad promedio de los pacientes fue de 41 años (límites de 16 a 59 años); 2 hombres y 10 mujeres. Tres paciente (25 por ciento) tuvieron afección aislada del ventrículo derecho; 1 paciente (8 por ciento), del ventrículo izquierdo y, en 8 pacientes (66 por ciento), el compromiso fue biventricular. Los hallazgos ecocardiográficos Doppler fueron: dilatación de la aurícula derecha (91 por ciento), dilatación del tracto de salida del ventrículo derecho (83 por ciento), movimiento septal paradójico (83 por ciento), dilatación de la aurícula izquierda (33 por ciento), prolapso valvular mitral y tricuspídeo (50 por ciento), derrame pericárdico (41 por ciento), insuficiencia mitral (75 por ciento), insuficiencia tricuspídea (100 por ciento), obliteración de ápex (50 por ciento) y patrón de llenado tipo restrictivo (50 por ciento). La ecocardiografía Doppler es un método útil en el diagnóstico de la fibrosis endomiocárdica, los hallazgos de ventrículos normales o pequeños con obliteración del ápex, que contrasta con aurículas muy dilatadas, de insuficiencia mitral y/o tricuspídea con un patrón de llenado de tipo restrictivo son característicos de esta enfermead. En nuestro medio, la localización aislada o predominante del ventrículo derecho fue la más frecuente: respresentó el 83 por ciento de los casos.
Assuntos
Humanos , Masculino , Feminino , Adolescente , Adulto , Ecocardiografia Doppler , Fibrose EndomiocárdicaRESUMO
In order to investigate the presence of secondary amyloidosis in patients with rheumatoid artritis (RA), we performed and abdominal subcutaneous fat biopsy with a truc-cut needle in 50 patients. The tissue was stained with Congo red and was observed with polarized light microscopy. We found amyloid deposits in 78 percent of our patientas. We randomly selected ten patients with a positive biopsy and a second procedure was performed. Tissues were studied with electron microscopy. We found unbranced fibrils characteristic of amyloid in all of them. We found a direct correlation with rheumatoid factor titers: the more intense the amyloid deposit, the higher the rheumatoid factor titers (p< 0.001). We did not find any correlation betwen amyloid deposits and clinical manifestations of disease. Amyloid deposits in RA are more frequent than previously thought, and their clinical importance remains to be determined
Assuntos
Humanos , Masculino , Feminino , Adolescente , Adulto , Pessoa de Meia-Idade , Amiloidose/diagnóstico , Artrite Reumatoide/fisiopatologiaRESUMO
The need to control recurrent biliary strictures implies the practice of repeated major surgical procedures. The hepaticojejunostomy with subcutaneous jejunal access (Chen's procedure) allows the permanent option of a non-operative management of recurrent biliary tract anastomosis complications. Through the subcutaneous jejunal access, the application of a Gianturco metallic prosthesis is permitted and the correction of biliary-intestinal anastomosis strictures with non-operative methods is possible. This report is a review of a series of 20 patients treated with the Chen procedure, of whom 3 patients also had implantation of Gianturco stents via hepaticojejunostomy with subcutaneous access.
Assuntos
Doenças Biliares/cirurgia , Ducto Hepático Comum/cirurgia , Jejunostomia/métodos , Stents , Adulto , Idoso , Anastomose em-Y de Roux , Constrição Patológica , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , RecidivaRESUMO
El estudio de las otoemisiones acusticas, por su rapidez, objetividad, simplicidad e inocuidad presenta una nueva alternativa en la evaluación precoz de la audición en lactantes, complementaria a las técnicas electrofisiológicas. Su indicación en la valoración de la audición en adultos y diagnóstico de diferentes tipos de hipoacusia, esta aun restringido y discutido. Otro gran atractivo de este novedoso examen es de caracter investigativo en el estudio de la fisiologia y patologia del oído interno
Assuntos
Protocolos Clínicos , Audição , ZumbidoRESUMO
Estudiamos cuatro casos de P.A.N. cutánea, entre los cuales destacamos el cuadro clínico caracterizado por una etapa inicial de fiebre, pérdida de peso, artralgias, mialgias y lesiones eritemato-papulares dolorosas y quemantes que afectan especialmente los miembros inferiores; en la segunda etapa, las lesiones se transformaban en lesione úlcero-necróticas entre la 2a. y 3a. semanas de la lesión antes mencionada y finalmente, la 3a. etapa, en la cual después de un tratamiento adecuado, estas lesiones se convertían en cicatrices atróficas. Revisamos los 94 casos comunicados en la literatura y no encontramos esta forma de presentación, razón por la cual queremos proponer esta variante de P.A.N. cutánea
Assuntos
Adolescente , Adulto , Humanos , Masculino , Feminino , Poliarterite Nodosa/complicações , Poliarterite Nodosa/tratamento farmacológico , Poliarterite Nodosa/patologia , Úlcera/complicações , Úlcera/patologia , Úlcera/tratamento farmacológico , Azatioprina/uso terapêutico , Ciclofosfamida/uso terapêutico , Prednisona/uso terapêuticoRESUMO
This is a report of a case a larval granulomatosis associated with immunoblastic lymphadenopathy, corroborated by laboratory and histologic studies compatible with that. The etiopathogenesis, clinical picture and diagnosis of both diseases are commented, and the possible relationship between them is stressed.