RESUMO
BACKGROUND: A genetic association between osteoarthritis (OA) and a polymorphism in the aspartic acid (D) repeat of the asporin (ASPN) gene has been reported in Japanese, Han Chinese, Greek and UK Caucasian populations of patients having knee and hip OA. Such an association has not been previously described among the Mexican mestizo population. The aim of this study was to analyze the association of the ASPN gene D-repeat polymorphism in a Mexican mestizo population with primary knee OA as well as in healthy controls. MATERIALS AND METHODS: A case-control study was conducted on a Mexican mestizo population of northern Mexico. The repeat polymorphism was genotyped in 440 subjects (218 cases and 222 healthy controls). Primary knee OA was diagnosed according to American College of Rheumatology and Kellgren-Lawrence criteria, and allelic association was examined adjusting for other risk variables. RESULTS: After adjusting for some covariates, menopause and the D16 allele showed a trend toward being risk factors for knee OA in a Mexican mestizo population. Also, the D12 allele could be considered as a protective factor. CONCLUSIONS: These findings suggest that polymorphisms within the ASPN gene could influence knee OA susceptibility, but these associations must be confirmed by independent studies in larger samples and different ethnic groups to support the role of the D-repeat polymorphism in the ASPN gene as risk or protection factors for knee OA in a Mexican population.
Assuntos
Proteínas da Matriz Extracelular/genética , Osteoartrite do Joelho/genética , Polimorfismo Genético , Estudos de Casos e Controles , Feminino , Humanos , Masculino , México , Pessoa de Meia-IdadeRESUMO
We describe for the first time the high-resolution profiling of HLA-A, -B, -C, -DRB1, -DQB1 and -DPB1 in a culturally and geographically distinct Mexican ethnic group, the Tarahumaras. The alleles most frequently found by reference strand-mediated conformational analysis in this population were for class I: HLA-A*240201, *020101/09, *0206, *310102, *680102; HLA-B*4002, *1501, *510201, *3501/02/03, *4005, *4801; HLA-Cw*0304, *0801, *0102, *040101; and for class II: HLA-DRB1*080201, *1402, *040701; HLA-DQB1*0402, *0301, *0302/07; HLA-DPB1*0402, *0401, *020102. In addition, a novel allele, HLA-A*0257, was found. Based on comparison of presently known HLA-DRB1 and -DQB1 allele frequencies in Amerindian groups and worldwide populations, the Tarahumaras are unexpectedly more related to the geographically and linguistically distant Aymara and Terena Amerindian groups than they are to neighbouring tribes.
Assuntos
Genes MHC da Classe II , Genes MHC Classe I , Indígenas Norte-Americanos/genética , Filogenia , Etnicidade/genética , Geografia , Haplótipos , Análise Heteroduplex , Humanos , Idioma , México , Polimorfismo GenéticoRESUMO
At present there are no poison center or toxicology services available in Ecuador. In preparation to begin such a service it was decided to evaluate the occurrence and causes of poisoning in Quito (population 1.5 million). A retrospective chart review was performed for all of 1995 of all the patients admitted to the emergency departments of 3 main public hospitals of Quito for poisoning, excluding those who had ethanol and food poisoning. We analyzed sex, age, socio-economic status, origin and principal causes of poisoning; 850 cases were located. Predominant age groups seen were 15-30 y and 31-45 y. Poisoning with drugs was the major cause with 211 cases, followed by organophosphate and phosphorus poisoning. Principal drugs seen in poisoning were benzodiazepine, acetaminophen and aspirin. The occurrence of poisoning in Quito showed unique regional differences that will help prepare local health officials to establish intervention strategies for the reduction of morbidity and mortality from poisoning. Significant efforts in both public and professional education will need to be made to both reduce occurrence and better treat poisonings.