RESUMO
The objective of this study was to analyze the serum sample levels of selenium and copper in healthy volunteers living in the city Rio de Janeiro. Thirty individuals were submitted for nutritional assessment, electrocardiogram, echocardiogram, and serum selenium and copper analysis through hydride generation and flame atomic absorption spectrometry, respectively. The accuracy and precision of these methods were evaluated using certified reference materials. None of the studied individuals was undernourished; 53% were overweight and 13.3% were slightly obese. The mean serum selenium level was 73.18+/-9.9 microg/l (56.50-94.50 microg/l). Among women it was 76.28+/-8.7 microg/l and in men 72.23+/-10.24 microg/l (P=0.35). Among non-white individuals the mean was 73.12+/-12.57 microg/l and in the white individuals it was 73.20+/-9.11 microg/l (P=0.98). The mean serum level of copper was 1.09+/-0.39 mg/l (0.56-1.80 mg/l). The mean found in women was 0.99+/-0.22 mg/l and in the men 1.13+/-0.43 mg/l (P=0.42). In non-white individuals it was 1.36+/-0.48 mg/l and in white individuals was 1.00+/-0.31 mg/l (P=0.02). The authors concluded that selenium and copper serum levels observed in this study were similar to those found in other cities.
Assuntos
Cobre/sangue , Exposição Ambiental , Selênio/sangue , Adulto , Brasil , Etnicidade , Feminino , Humanos , Masculino , Estado Nutricional , Valores de Referência , Fatores Sexuais , População UrbanaRESUMO
OBJECTIVE: To analyze the association of thiamin, selenium, and copper serum levels with cardiac function in patients with idiopathic dilated cardiomyopathy using diuretics, and also to compare them with levels in control patients with no evidence of disease. METHODS: The study comprised 30 patients with heart disease and 30 healthy control individuals. Thiamin was analyzed by measuring the activity of erythrocytic transketolase and the effect of thiamin pyrophosphate. Selenium and copper serum levels were measured by hydride generation and flame atomic absorption spectrophotometry, respectively. RESULTS: Thiamin deficiency was observed in 10% of the control individuals and in 33% of the patients with heart disease (p=0.02). The mean selenium and copper serum levels in control individuals and patients with heart disease were, respectively, 73.2+/-9.9 microg/L (56.5 to 94.5 microg/L) and 72.3+/-14.3 microg/L (35.5 to 94 microg/L) (p=0.77); 1.1+/-0.4 mg/L (0.6 to 1.8 mg/L) and 1.2+/- 0.4 mg/L (0.6 to 2.2 mg/L) (p=0.27). No association between the levels of these nutrients and cardiac function was observed. CONCLUSION: Thiamin deficiency was significantly more frequent in patients with heart disease. No significant difference was observed between the mean selenium and copper serum levels in control individuals and in patients with heart disease. The results suggest possible benefits with thiamin replacement in patients taking diuretics.
Assuntos
Cardiomiopatia Dilatada/sangue , Cobre/sangue , Diuréticos/uso terapêutico , Selênio/sangue , Tiamina/sangue , Adulto , Cardiomiopatia Dilatada/tratamento farmacológico , Diuréticos/efeitos adversos , Feminino , Humanos , Masculino , Estado Nutricional , Volume Sistólico , Tiamina/uso terapêutico , Deficiência de Tiamina/sangue , Deficiência de Tiamina/induzido quimicamente , Deficiência de Tiamina/tratamento farmacológicoRESUMO
OBJECTIVE - To analyze the association of thiamin, selenium, and copper serum levels with cardiac function in patients with idiopathic dilated cardiomyopathy using diuretics, and also to compare them with levels in control patients with no evidence of disease. METHODS - The study comprised 30 patients with heart disease and 30 healthy control individuals. Thiamin was analyzed by measuring the activity of erythrocytic transketolase and the effect of thiamin pyrophosphate. Selenium and copper serum levels were measured by hydride generation and flame atomic absorption spectrophotometry, respectively. RESULTS - Thiamin deficiency was observed in 10 percent of the control individuals and in 33 percent of the patients with heart disease (p=0.02). The mean selenium and copper serum levels in control individuals and patients with heart disease were, respectively, 73.2±9.9 µg/L (56.5 to 94.5 µg/L) and 72.3±14.3 µg/L (35.5 to 94 µg/L) (p=0.77); 1.1±0.4mg/L (0.6 to 1.8mg/L) and 1.2± 0.4mg/L (0.6 to 2.2mg/L) (p=0.27). No association between the levels of these nutrients and cardiac function was observed. CONCLUSION - Thiamin deficiency was significantly more frequent in patients with heart disease. No significant difference was observed between the mean selenium and copper serum levels in control individuals and in patients with heart disease. The results suggest possible benefits with thiamin replacement in patients taking diuretics