RESUMO

Eighteen normotensive patients with coronary disease and stable effort-induced angina were selected. The effect of captopril was studied. A Bruce stress test was obtained before and after administration of conventional treatment with captopril or placebo. The captopril induced less systolic pressure elevation during maximal exercise without modification of heart rate. By decreasing myocardial oxygen consumption, increasing the time in which angina appears during exercise. Captopril may prove to be useful adjunct to the antianginal drug regimens of patients with stable angina and systolic arterial pressure greater than 110 mm Hg.

Assuntos

Angina Pectoris/tratamento farmacológico , Captopril/uso terapêutico , Adulto , Idoso , Angina Pectoris/diagnóstico , Angina Pectoris/fisiopatologia , Pressão Sanguínea/efeitos dos fármacos , Captopril/administração & dosagem , Relação Dose-Resposta a Droga , Avaliação de Medicamentos , Eletrocardiografia , Teste de Esforço , Feminino , Frequência Cardíaca/efeitos dos fármacos , Humanos , Masculino , Pessoa de Meia-Idade