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Curr Top Med Chem ; 20(9): 738-745, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32101124

RESUMO

AIMS: The present study aims to determine the phototoxic and haemolytic activity of organophosphorus. The use of alternative in vitro assays with human erythrocytes is suggested to predict the polluting effect of these products on health. METHODOLOGY: Human erythrocytes from Toluca Blood Bank were used. Sodium dodecyl sulfate was employed as a positive control. Additionally, the haemolysis percentage of three organophosphate (Acetate, Chlorpyrifos, Malathion, Methamidophos, Methyl Parathion) induced photo haemolysis formulated with surfactants on a concentration of 2 x 109 erythrocytes were evaluated. Finally, the products were classified as irritant or phototoxic. RESULTS: Results showed that the HC50 red blood cells were similar for each organophosphate (Malathion and Methamidophos) indicating very irritant action with ratio classification (L/D) of 0.041 and 0.053, respectively. On the other hand, Chlorpyrifos was classified as an irritant with L/D= 0.14. On the other hand, the HC50 obtained photo hemolysis assays irradiated red blood cells was similar for each organophosphate (Acetate, Chlorpyrifos, Malathion, Methamidophos, Methyl Parathion) indicating no phototoxic action. CONCLUSION: As a conclusion, it can be said that the parameters of haemolysis and denaturation of proteins are good indicators to classify organophosphorus formulated with surfactants as irritating or phototoxic.


Assuntos
Eritrócitos/metabolismo , Hemólise/efeitos dos fármacos , Hemólise/efeitos da radiação , Compostos Organofosforados/química , Fotoquimioterapia/métodos , Tensoativos/química , Clorpirifos/química , Humanos , Técnicas In Vitro , Malation/química , Intoxicação por Organofosfatos , Compostos Organotiofosforados/química , Desnaturação Proteica/efeitos dos fármacos
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