RESUMO
Although coronary atherosclerosis is considered to have several etiologic factors there is little doubt that elevated plasmatic cholesterol level is the main one. The present study was carried out because of the lack of information concerning cholesterol, lipoproteins and triglycerides levels in the coronary population in Argentina. Patients were selected on the basis of a demonstrated coronary atherosclerosis, detected either by an abnormal coronary arteriogram or a documented myocardial infarction. Total seric cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C) and triglycerides (TG) were determined in a core laboratory. Blood samples were obtained after a 12 hour fasting period. LDL-C was also calculated by the Friedewald formula. Patients were stratified according to sex, age, having or not myocardial infarction, type (Q or non Q wave) and localization of myocardial infarction. A total of 653 patients were included. The mean values obtained were: TC 227 +/- 1.8 mg/dL; LDL-C 153 +/- 1.8 mg/dL; HDL-C 48 +/- 0.4 mg/dL and TG 180 +/- 3.6 mg/dL (expressed as mean +/- SE). Mean values in the male and female subsets are given in Table 1. In women, TC, LDL-C and HDL-C are significantly higher than in men. Cholesterol values according to age are displayed in Table 3. Young people have higher TC and LDL-C mean values than older ones. Different cholesterol levels were not observed when the coronary population in our study was stratified according to the presence or not of previous myocardial infarction (Table 4).(ABSTRACT TRUNCATED AT 250 WORDS)
Assuntos
Doença da Artéria Coronariana/sangue , Lipídeos/sangue , Adulto , Fatores Etários , Idoso , Argentina , Colesterol/sangue , HDL-Colesterol/sangue , LDL-Colesterol/sangue , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Infarto do Miocárdio/sangue , Fatores Sexuais , Triglicerídeos/sangueRESUMO
El Estudio Nacional de Lípidos en Pacientes Coronarios (ES.NA.LI.CO) es un estudio multicéntrico realizado en 8 ciudades del país. Se analizaron los niveles de colesterol total, HDL, LDL y triglicéridos en 653 pacientes con enfermedad coronaria aterosclerótica confirmada por coronariografia y/o infarto de miocardio documentado. El colesterol LDL fue medido además de calculado por la fórmula de Friedewald. Los pacientes fueron estratificados por protocolo según sexo, edad, presencia o no de infarto de miocardio, tipo de enfarto (Q o no Q) y localización del mismo. Los valores medios para la población total fueron: colesterol total 227 mg/dL; HDL 46 mg/dL y LDL 153 mg/dL. El colesterol total y LDL fueron significativamente mayores en las mujeres, en los más jóvenes, en los pacientes con infarto de miocardio sin onda Q y en los infartos anteriores. No hubo diferencias significativas en los grupos con y sin infarto de miocardio. El colesterol LDL medido fue 7% mayor que el calculado. En conclusión, el nivel medio de colesterol total y LDL en los pacientes con enfermedad coronaria se encuentra dentro del rango considerado normal hasta hace poco tiempo. Las mujeres y los jóvenes con enfermedad coronaria tienen colesterol total y LDL mayores que el promedio. Los pacientes con infarto no Q tienen colesterol total y LDL más alto que los pacientes con infarto con Q. La fórmula de Friedewald debería ser modificada reemplazando 1/5 por 1/6 de los triglicéridos. Se debe recomendar a la población valores de lípidos más bajos que los hallados por nosotros en los enfermos cornonarios
Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Doença da Artéria Coronariana/sangue , Lipídeos/sangue , Fatores Etários , Argentina , HDL-Colesterol/sangue , LDL-Colesterol/sangue , Colesterol/sangue , Infarto do Miocárdio/sangue , Estudos Multicêntricos como Assunto , Fatores Sexuais , Triglicerídeos/sangueRESUMO
Although coronary atherosclerosis is considered to have several etiologic factors there is little doubt that elevated plasmatic cholesterol level is the main one. The present study was carried out because of the lack of information concerning cholesterol, lipoproteins and triglycerides levels in the coronary population in Argentina. Patients were selected on the basis of a demonstrated coronary atherosclerosis, detected either by an abnormal coronary arteriogram or a documented myocardial infarction. Total seric cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C) and triglycerides (TG) were determined in a core laboratory. Blood samples were obtained after a 12 hour fasting period. LDL-C was also calculated by the Friedewald formula. Patients were stratified according to sex, age, having or not myocardial infarction, type (Q or non Q wave) and localization of myocardial infarction. A total of 653 patients were included. The mean values obtained were: TC 227 +/- 1.8 mg/dL; LDL-C 153 +/- 1.8 mg/dL; HDL-C 48 +/- 0.4 mg/dL and TG 180 +/- 3.6 mg/dL (expressed as mean +/- SE). Mean values in the male and female subsets are given in Table 1. In women, TC, LDL-C and HDL-C are significantly higher than in men. Cholesterol values according to age are displayed in Table 3. Young people have higher TC and LDL-C mean values than older ones. Different cholesterol levels were not observed when the coronary population in our study was stratified according to the presence or not of previous myocardial infarction (Table 4).(ABSTRACT TRUNCATED AT 250 WORDS)
RESUMO
El Estudio Nacional de Lípidos en Pacientes Coronarios (ES.NA.LI.CO) es un estudio multicéntrico realizado en 8 ciudades del país. Se analizaron los niveles de colesterol total, HDL, LDL y triglicéridos en 653 pacientes con enfermedad coronaria aterosclerótica confirmada por coronariografia y/o infarto de miocardio documentado. El colesterol LDL fue medido además de calculado por la fórmula de Friedewald. Los pacientes fueron estratificados por protocolo según sexo, edad, presencia o no de infarto de miocardio, tipo de enfarto (Q o no Q) y localización del mismo. Los valores medios para la población total fueron: colesterol total 227 mg/dL; HDL 46 mg/dL y LDL 153 mg/dL. El colesterol total y LDL fueron significativamente mayores en las mujeres, en los más jóvenes, en los pacientes con infarto de miocardio sin onda Q y en los infartos anteriores. No hubo diferencias significativas en los grupos con y sin infarto de miocardio. El colesterol LDL medido fue 7% mayor que el calculado. En conclusión, el nivel medio de colesterol total y LDL en los pacientes con enfermedad coronaria se encuentra dentro del rango considerado normal hasta hace poco tiempo. Las mujeres y los jóvenes con enfermedad coronaria tienen colesterol total y LDL mayores que el promedio. Los pacientes con infarto no Q tienen colesterol total y LDL más alto que los pacientes con infarto con Q. La fórmula de Friedewald debería ser modificada reemplazando 1/5 por 1/6 de los triglicéridos. Se debe recomendar a la población valores de lípidos más bajos que los hallados por nosotros en los enfermos cornonarios (AU)
Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Idoso , Doença da Artéria Coronariana/sangue , Lipídeos/sangue , Colesterol/sangue , HDL-Colesterol/sangue , LDL-Colesterol/sangue , Triglicerídeos/sangue , Fatores Sexuais , Fatores Etários , Infarto do Miocárdio/sangue , Estudos Multicêntricos como Assunto , ArgentinaRESUMO
Although coronary atherosclerosis is considered to have several etiologic factors there is little doubt that elevated plasmatic cholesterol level is the main one. The present study was carried out because of the lack of information concerning cholesterol, lipoproteins and triglycerides levels in the coronary population in Argentina. Patients were selected on the basis of a demonstrated coronary atherosclerosis, detected either by an abnormal coronary arteriogram or a documented myocardial infarction. Total seric cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C) and triglycerides (TG) were determined in a core laboratory. Blood samples were obtained after a 12 hour fasting period. LDL-C was also calculated by the Friedewald formula. Patients were stratified according to sex, age, having or not myocardial infarction, type (Q or non Q wave) and localization of myocardial infarction. A total of 653 patients were included. The mean values obtained were: TC 227 +/- 1.8 mg/dL; LDL-C 153 +/- 1.8 mg/dL; HDL-C 48 +/- 0.4 mg/dL and TG 180 +/- 3.6 mg/dL (expressed as mean +/- SE). Mean values in the male and female subsets are given in Table 1. In women, TC, LDL-C and HDL-C are significantly higher than in men. Cholesterol values according to age are displayed in Table 3. Young people have higher TC and LDL-C mean values than older ones. Different cholesterol levels were not observed when the coronary population in our study was stratified according to the presence or not of previous myocardial infarction (Table 4).(ABSTRACT TRUNCATED AT 250 WORDS)