RESUMO
Hemos planteado el presente trabajo, teniendo en cuenta los siguientes aspectos: describir las características epidemiológicas y demográficas en la población estudiada y además caracterizar especialmente los factores higiénicos, sanitarios y culturales que por su heterogeneidad, tuvieron influencia en la capacidad de infección por el Helicobacter Pylori
Assuntos
Adolescente , Adulto , Humanos , Idoso , Demografia , Escolaridade , Estudos Epidemiológicos , Indicadores Básicos de Saúde , Helicobacter pylori , Indicadores Econômicos/estatística & dados numéricos , Qualidade de Vida , Classe SocialRESUMO
Hemos planteado el presente trabajo, teniendo en cuenta los siguientes aspectos: describir las características epidemiológicas y demográficas en la población estudiada y además caracterizar especialmente los factores higiénicos, sanitarios y culturales que por su heterogeneidad, tuvieron influencia en la capacidad de infección por el Helicobacter Pylori
Assuntos
Adolescente , Adulto , Humanos , Idoso , Helicobacter pylori/classificação , Estudos Epidemiológicos , Qualidade de Vida , Classe Social , Indicadores Econômicos/estatística & dados numéricos , Indicadores Básicos de Saúde , Qualidade de Vida , Escolaridade , DemografiaRESUMO
OBJECTIVE: To compare the acid-supressing capacity of omeprazole (OZ) 20 mg tablets vs pantoprazole (PZ) 20 and 40 mg tablets, in healthy volunteers, with 24-h intragastric pH-metry. MATERIAL AND METHODS: Open, randomized, cross-over trial in 10 healthy volunteers; on days 0.8 and 22, 24-h intragastric pH-metry. Day 0, basal, thereafter 7 days with OZ or PZ 20 mg/day; day 8, pH-metry, then "wash out" for 7 days and thereafter 7 more days' therapy with PZ or OZ. On day 22 a 24-h intragastric pH control was performed again. In the last treatment stage, all of them were administered pantoprazole 40 mg/day for 8 days again with a 24-h pH recording at the end. RESULTS: 24-h pH-metry expressed as the time (hours) in which the pH was < or = 4 and the values as mean +/- standard deviation. BASAL 22.12 +/- 1.54, POST-OZ 9.78 +/- 6.72, POST-PZ 20 15.65 +/- 5.65, POST-PZ 40 8.57 +/- 5.93. Statistical evaluation with two way repeated measures ANOVA p < 0.0001. Newman Keuls post-hoc test: (1) vs (2) p < 0.003; (1) vs (3) p < 0.03; (2) vs (4) 0.65. CONCLUSIONS: According to the results it might be stated that both proton pump inhibitors have acid-supressing capacity and omeprazole in equal dosis is more effective than pantoprazole as acid-supressor, with statistically significative differences. There was no difference between 20 mg omeprazole and 40 mg pantoprazole.
Assuntos
Antiulcerosos/farmacologia , Benzimidazóis/farmacologia , Ácido Gástrico/metabolismo , Omeprazol/farmacologia , Inibidores da Bomba de Prótons , Sulfóxidos/farmacologia , 2-Piridinilmetilsulfinilbenzimidazóis , Adulto , Análise de Variância , Estudos Cross-Over , Feminino , Humanos , Concentração de Íons de Hidrogênio , Masculino , Pessoa de Meia-Idade , Pantoprazol , Fatores de TempoRESUMO
OBJECTIVE: To compare the acid-supressing capacity of omeprazole (OZ) 20 mg tablets vs pantoprazole (PZ) 20 and 40 mg tablets, in healthy volunteers, with 24-h intragastric pH-metry. MATERIAL AND METHODS: Open, randomized, cross-over trial in 10 healthy volunteers; on days 0.8 and 22, 24-h intragastric pH-metry. Day 0, basal, thereafter 7 days with OZ or PZ 20 mg/day; day 8, pH-metry, then [quot ]wash out[quot ] for 7 days and thereafter 7 more days therapy with PZ or OZ. On day 22 a 24-h intragastric pH control was performed again. In the last treatment stage, all of them were administered pantoprazole 40 mg/day for 8 days again with a 24-h pH recording at the end. RESULTS: 24-h pH-metry expressed as the time (hours) in which the pH was < or = 4 and the values as mean +/- standard deviation. BASAL 22.12 +/- 1.54, POST-OZ 9.78 +/- 6.72, POST-PZ 20 15.65 +/- 5.65, POST-PZ 40 8.57 +/- 5.93. Statistical evaluation with two way repeated measures ANOVA p < 0.0001. Newman Keuls post-hoc test: (1) vs (2) p < 0.003; (1) vs (3) p < 0.03; (2) vs (4) 0.65. CONCLUSIONS: According to the results it might be stated that both proton pump inhibitors have acid-supressing capacity and omeprazole in equal dosis is more effective than pantoprazole as acid-supressor, with statistically significative differences. There was no difference between 20 mg omeprazole and 40 mg pantoprazole.
RESUMO
OBJECTIVE: To compare the acid-supressing capacity of omeprazole (OZ) 20 mg tablets vs pantoprazole (PZ) 20 and 40 mg tablets, in healthy volunteers, with 24-h intragastric pH-metry. MATERIAL AND METHODS: Open, randomized, cross-over trial in 10 healthy volunteers; on days 0.8 and 22, 24-h intragastric pH-metry. Day 0, basal, thereafter 7 days with OZ or PZ 20 mg/day; day 8, pH-metry, then "wash out" for 7 days and thereafter 7 more days therapy with PZ or OZ. On day 22 a 24-h intragastric pH control was performed again. In the last treatment stage, all of them were administered pantoprazole 40 mg/day for 8 days again with a 24-h pH recording at the end. RESULTS: 24-h pH-metry expressed as the time (hours) in which the pH was < or = 4 and the values as mean +/- standard deviation. BASAL 22.12 +/- 1.54, POST-OZ 9.78 +/- 6.72, POST-PZ 20 15.65 +/- 5.65, POST-PZ 40 8.57 +/- 5.93. Statistical evaluation with two way repeated measures ANOVA p < 0.0001. Newman Keuls post-hoc test: (1) vs (2) p < 0.003; (1) vs (3) p < 0.03; (2) vs (4) 0.65. CONCLUSIONS: According to the results it might be stated that both proton pump inhibitors have acid-supressing capacity and omeprazole in equal dosis is more effective than pantoprazole as acid-supressor, with statistically significative differences. There was no difference between 20 mg omeprazole and 40 mg pantoprazole.(AU)
Assuntos
Estudo Comparativo , Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Benzimidazóis/farmacologia , Omeprazol/farmacologia , Ácido Gástrico/metabolismo , Inibidores Enzimáticos/farmacologia , Bombas de Próton/antagonistas & inibidores , Sulfóxidos/farmacologia , Benzimidazóis/administração & dosagem , Omeprazol/administração & dosagem , Estudos Cross-Over , Concentração de Íons de Hidrogênio , Inibidores Enzimáticos/administração & dosagem , Fatores de Tempo , Determinação da Acidez Gástrica , Distribuição Aleatória , Análise de Variância , Manometria , Sulfóxidos/administração & dosagemRESUMO
OBJECTIVE: To compare the acid-supressing capacity of omeprazole (OZ) 20 mg tablets vs pantoprazole (PZ) 20 and 40 mg tablets, in healthy volunteers, with 24-h intragastric pH-metry. MATERIAL AND METHODS: Open, randomized, cross-over trial in 10 healthy volunteers; on days 0.8 and 22, 24-h intragastric pH-metry. Day 0, basal, thereafter 7 days with OZ or PZ 20 mg/day; day 8, pH-metry, then "wash out" for 7 days and thereafter 7 more days' therapy with PZ or OZ. On day 22 a 24-h intragastric pH control was performed again. In the last treatment stage, all of them were administered pantoprazole 40 mg/day for 8 days again with a 24-h pH recording at the end. RESULTS: 24-h pH-metry expressed as the time (hours) in which the pH was < or = 4 and the values as mean +/- standard deviation. BASAL 22.12 +/- 1.54, POST-OZ 9.78 +/- 6.72, POST-PZ 20 15.65 +/- 5.65, POST-PZ 40 8.57 +/- 5.93. Statistical evaluation with two way repeated measures ANOVA p < 0.0001. Newman Keuls post-hoc test: (1) vs (2) p < 0.003; (1) vs (3) p < 0.03; (2) vs (4) 0.65. CONCLUSIONS: According to the results it might be stated that both proton pump inhibitors have acid-supressing capacity and omeprazole in equal dosis is more effective than pantoprazole as acid-supressor, with statistically significative differences. There was no difference between 20 mg omeprazole and 40 mg pantoprazole.
Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Benzimidazóis/farmacologia , Inibidores Enzimáticos/farmacologia , Ácido Gástrico , Omeprazol/farmacologia , Bombas de Próton/antagonistas & inibidores , Sulfóxidos/farmacologia , Análise de Variância , Benzimidazóis/administração & dosagem , Estudos Cross-Over , Inibidores Enzimáticos/administração & dosagem , Determinação da Acidez Gástrica , Concentração de Íons de Hidrogênio , Manometria , Omeprazol/administração & dosagem , Distribuição Aleatória , Sulfóxidos/administração & dosagem , Fatores de TempoRESUMO
Nowadays technics for Helicobacter pylori detection in stools like culture, and PCR, are expensive and difficult to perform. The aim of this study was to evaluate ELISA test efficacy for detection of H. Pylori antigens in stools comparing this results with standarized technics like histology (Giemsa), ureasa test and UBT C 14. 26 patients were evaluated in this study, ages between 15-75 with upper gastrointestinal symptoms; all of them required gastroduodenal endoscopy, status H. Pylori was determined with methods upon mentioned. 24 hours after endoscopy H. Pylori antigens in stools with the technique Premier Platinum Htsa, Elisa were determined. The detection of H. Pylori antigens in stools accurately identified active H. Pylori infection. The performance characteristics of this non-invasive method was similar in sensibility and specificity to conventional tests
Assuntos
Humanos , Masculino , Feminino , Adolescente , Adulto , Pessoa de Meia-Idade , Antígenos de Bactérias , Fezes , Infecções por Helicobacter , Helicobacter pylori , Técnicas Imunoenzimáticas , Ensaio de Imunoadsorção Enzimática , Sensibilidade e EspecificidadeRESUMO
Nowadays technics for Helicobacter pylori detection in stools like culture, and PCR, are expensive and difficult to perform. The aim of this study was to evaluate ELISA test efficacy for detection of H. Pylori antigens in stools comparing this results with standarized technics like histology (Giemsa), ureasa test and UBT C 14. 26 patients were evaluated in this study, ages between 15-75 with upper gastrointestinal symptoms; all of them required gastroduodenal endoscopy, status H. Pylori was determined with methods upon mentioned. 24 hours after endoscopy H. Pylori antigens in stools with the technique Premier Platinum Htsa, Elisa were determined. The detection of H. Pylori antigens in stools accurately identified active H. Pylori infection. The performance characteristics of this non-invasive method was similar in sensibility and specificity to conventional tests (AU)
Assuntos
Humanos , Masculino , Feminino , Adolescente , Adulto , Pessoa de Meia-Idade , Idoso , Antígenos de Bactérias/análise , Fezes/microbiologia , Infecções por Helicobacter/diagnóstico , Helicobacter pylori/imunologia , Técnicas Imunoenzimáticas/métodos , Ensaio de Imunoadsorção Enzimática/normas , Sensibilidade e EspecificidadeRESUMO
Nowadays technics for Helicobacter pylori detection in stools like culture, and PCR, are expensive and difficult to perform. The aim of this study was to evaluate ELISA test efficacy for detection of H. Pylori antigens in stools comparing this results with standarized technics like histology (Giemsa), ureasa test and UBT C 14. 26 patients were evaluated in this study, ages between 15-75 with upper gastrointestinal symptoms; all of them required gastroduodenal endoscopy, status H. Pylori was determined with methods upon mentioned. 24 hours after endoscopy H. Pylori antigens in stools with the technique Premier Platinum Htsa, Elisa were determined. The detection of H. Pylori antigens in stools accurately identified active H. Pylori infection. The performance characteristics of this non-invasive method was similar in sensibility and specificity to conventional tests.
Assuntos
Antígenos de Bactérias/análise , Fezes/microbiologia , Infecções por Helicobacter/diagnóstico , Helicobacter pylori/imunologia , Técnicas Imunoenzimáticas/métodos , Adolescente , Adulto , Idoso , Ensaio de Imunoadsorção Enzimática/normas , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Sensibilidade e EspecificidadeRESUMO
Some papers report helicobacter pylori existence in bile from surgical specimens obtained during gallbladder or bile ducts surgery. The aim of this work was search by PCR, H. Pylori presence in bile specimens from patients suffering of gallbladder stones or by bile ducts stones. Bile samples were obtained by gallbladder punction during cholecystectomy in 26 patients, 19 of them with gallbladder stones and 7 also with gallbladder stones and bile duct stones. Age ranged from 22-69 years old, median 49.6 years old. Samples were sent to specialized biomolecular laboratory to perform PCR techniques. Two of 26 patients (7.6%) had positive reaction for the presence of DNA of H. Pylori in bile samples. Our research suggest that DNA of H. Pylori can be founded in bile samples patients with gallbladders and duct stones in Argentina.
Assuntos
Colelitíase/microbiologia , Infecções por Helicobacter/microbiologia , Helicobacter pylori/isolamento & purificação , Adulto , Idoso , Doenças dos Ductos Biliares/microbiologia , DNA Bacteriano/análise , Humanos , Pessoa de Meia-IdadeRESUMO
Algunos trabajos describen la presencia de H. Pylori en muestras de bilis obtenidas durante la cirurgía por litiasis en vesícula y vías biliares. El objetivo de este trabajo, ha sido detectar la presencia del ADN del H. Pylori por medio de la Reacción en cadena de la Polimerasa (PCR) en muestras de bilis de pacientes con litasis vesicular y/o de vías biliares. Las muestras de bilis fueron obtenidas de 26 pacientes, 19 con litiasis vesicular y 7 con litiasis vesicular y coledociana, con edades comprendidas entre 22 a 69 años, media de 49,6 años, por punción de vesicular durante la colecistectomia. Las muestras fueron tratadas adecuadamente y preparadas para su investigación por PCR. 2 de 26 casos (7,6 por ciento) fueron positivos para la presencia en bilis del DNA del H. Pylori. Nuestro trabajo sugiere que el DNA del H P puede ser encontrado en muestras de bilis de pacientes portadores de litiasis biliar en la Argentina.
Assuntos
Humanos , Idoso , Pessoa de Meia-Idade , Adulto , Colelitíase/microbiologia , Infecções por Helicobacter/microbiologia , Helicobacter pylori/isolamento & purificação , Doenças dos Ductos Biliares/microbiologia , Colecistectomia , DNA Bacteriano/análise , Reação em Cadeia da PolimeraseRESUMO
Algunos trabajos describen la presencia de H. Pylori en muestras de bilis obtenidas durante la cirurgía por litiasis en vesícula y vías biliares. El objetivo de este trabajo, ha sido detectar la presencia del ADN del H. Pylori por medio de la Reacción en cadena de la Polimerasa (PCR) en muestras de bilis de pacientes con litasis vesicular y/o de vías biliares. Las muestras de bilis fueron obtenidas de 26 pacientes, 19 con litiasis vesicular y 7 con litiasis vesicular y coledociana, con edades comprendidas entre 22 a 69 años, media de 49,6 años, por punción de vesicular durante la colecistectomia. Las muestras fueron tratadas adecuadamente y preparadas para su investigación por PCR. 2 de 26 casos (7,6 por ciento) fueron positivos para la presencia en bilis del DNA del H. Pylori. Nuestro trabajo sugiere que el DNA del H P puede ser encontrado en muestras de bilis de pacientes portadores de litiasis biliar en la Argentina. (AU)
Assuntos
Humanos , Idoso , Pessoa de Meia-Idade , Adulto , Helicobacter pylori/isolamento & purificação , Colelitíase/microbiologia , Infecções por Helicobacter/microbiologia , Reação em Cadeia da Polimerase , Doenças dos Ductos Biliares/microbiologia , Colecistectomia , DNA Bacteriano/análiseRESUMO
The mechanisms of transmission and reservoir of Helicobacter pylori is still unclear; even it has been suggested that dental plaque could be the bacterial reservoir and one important factor in the reinfection. The aim of the study was to evaluate the prevalence of Helicobacter pylori in dental plaque in 20 patients with non ulcer dyspepsia (12 females, 7 males; mean age 40.5 years) and antral infection; and to establish the presence of bacteria in dental plaque and gastric mucosa after eradication. Gastric colonization in all of them was confirmed by five samples (three of antrum and two of body) with Giemsa conventional technique, clotest and culture. When clotest was positive in gastric mucosa, we performed the scrape of dental plaque and sending the material for culture. All patients were treated with a scheme of seven days with one protom pump inhibitor and two antibiotics. After four weeks all the patients were controlled with endoscopy and culture of dental plaque to confirm eradication. Dental plaque culture was positive in 1/20 patients (5%), and this results was similar to developed countries, using as detection method culture or polymerase chain reaction (PCR).
Assuntos
Placa Dentária/microbiologia , Dispepsia/microbiologia , Infecções por Helicobacter/transmissão , Helicobacter pylori/isolamento & purificação , 2-Piridinilmetilsulfinilbenzimidazóis , Adolescente , Adulto , Idoso , Amoxicilina/uso terapêutico , Benzimidazóis/uso terapêutico , Claritromicina/uso terapêutico , Reservatórios de Doenças , Quimioterapia Combinada , Dispepsia/tratamento farmacológico , Inibidores Enzimáticos/uso terapêutico , Feminino , Infecções por Helicobacter/tratamento farmacológico , Humanos , Masculino , Pessoa de Meia-Idade , Omeprazol/análogos & derivados , Pantoprazol , Prevalência , Recidiva , Sulfóxidos/uso terapêuticoRESUMO
Si bien la forma de transmisión y el reservorio del Helicobacter pylori no son claros, se ha sugerido que la placa dentaria puede ser reservorio del germen y poseer inplicancias en la reinfección, una vez erradicada la bacteria. El objetivo de este trabajo fue evaluar la prevalencia del Helicobacter pylori en placa dentaria en 20 pacientes portadores de dispepsia no ulcerosa (12 mujeres y 7 varones con media etaria de 40.5 años)e infección antral por Helicobacter pylori y establecer la presencia en placa dentaria y mucosa gástrica luego de la erradicación. En todas ellas se confirmó la colonización gástrica mediante 5 biopsias (3 de antro y 2 de cuerpo) realizándose histología convencional com Giemsa clotest y cultivo en medio de anaerobiosis com generador de microaerofilia, usando como medio de transporte Stuard-carbón activado. Confirmada la positividad del clotest en mucosa gástrica, se procedió al raspado de placa dentaria en el servicio de odontología, enviándose el material en las mismas condiciones descriptas para el cultivo de la bacteria. Todos los pacientes fueron tratados com un esquema de erradicación a 7 días que incluía un IBP en dos tomas diarias; amoxicilina 1 gr. X 2 y claritromicina 500 mg. X 2. Cuatro semanas después de finalizado el esquema se realizó nueva endoscopía y cultivo de placa dentaria para confirmar erradicación. El cultivo de placa dentaria fue positivo en 1 de 20 es decir el 5 por ciento, confirmándose su erradicación com la terapeútica en el control a las 4 semanas. Nuestros resultados en cuanto a prevalencia de Hp en placa dentaria son similares a los obtenidos en países desarrollados, utilizando como método de detección de la bacteria el cultivo de PCR.
Assuntos
Adulto , Pessoa de Meia-Idade , Feminino , Humanos , Adolescente , Placa Dentária/microbiologia , Dispepsia/microbiologia , Infecções por Helicobacter/transmissão , Helicobacter pylori/isolamento & purificação , Amoxicilina/uso terapêutico , Benzimidazóis/uso terapêutico , Claritromicina/uso terapêutico , Reservatórios de Doenças , Quimioterapia Combinada , Dispepsia , Inibidores Enzimáticos/uso terapêutico , Infecções por Helicobacter/tratamento farmacológico , Infecções por Helicobacter/microbiologia , Reação em Cadeia da Polimerase , Prevalência , RecidivaRESUMO
Si bien la forma de transmisión y el reservorio del Helicobacter pylori no son claros, se ha sugerido que la placa dentaria puede ser reservorio del germen y poseer inplicancias en la reinfección, una vez erradicada la bacteria. El objetivo de este trabajo fue evaluar la prevalencia del Helicobacter pylori en placa dentaria en 20 pacientes portadores de dispepsia no ulcerosa (12 mujeres y 7 varones con media etaria de 40.5 años)e infección antral por Helicobacter pylori y establecer la presencia en placa dentaria y mucosa gástrica luego de la erradicación. En todas ellas se confirmó la colonización gástrica mediante 5 biopsias (3 de antro y 2 de cuerpo) realizándose histología convencional com Giemsa clotest y cultivo en medio de anaerobiosis com generador de microaerofilia, usando como medio de transporte Stuard-carbón activado. Confirmada la positividad del clotest en mucosa gástrica, se procedió al raspado de placa dentaria en el servicio de odontología, enviándose el material en las mismas condiciones descriptas para el cultivo de la bacteria. Todos los pacientes fueron tratados com un esquema de erradicación a 7 días que incluía un IBP en dos tomas diarias; amoxicilina 1 gr. X 2 y claritromicina 500 mg. X 2. Cuatro semanas después de finalizado el esquema se realizó nueva endoscopía y cultivo de placa dentaria para confirmar erradicación. El cultivo de placa dentaria fue positivo en 1 de 20 es decir el 5 por ciento, confirmándose su erradicación com la terapeútica en el control a las 4 semanas. Nuestros resultados en cuanto a prevalencia de Hp en placa dentaria son similares a los obtenidos en países desarrollados, utilizando como método de detección de la bacteria el cultivo de PCR. (AU)
Assuntos
Adulto , Pessoa de Meia-Idade , Idoso , Feminino , Humanos , Adolescente , Placa Dentária/microbiologia , Helicobacter pylori/isolamento & purificação , Infecções por Helicobacter/transmissão , Dispepsia/microbiologia , Quimioterapia Combinada , Amoxicilina/uso terapêutico , Claritromicina/uso terapêutico , Benzimidazóis/uso terapêutico , Reação em Cadeia da Polimerase , Recidiva , Prevalência , Reservatórios de Doenças , Inibidores Enzimáticos/uso terapêutico , Dispepsia , Infecções por Helicobacter/tratamento farmacológico , Infecções por Helicobacter/microbiologiaRESUMO
Systemic sclerosis is a collagen disease with high frequency of oesophageal affection, specially if we use manometry as an evaluation method that has a high rate of clinic complication in high rate of patients. The aim of the study was to evaluate the prevalence of the oesophageal affection through the clinical, radiological, endoscopical and manometrical studies and to compare the results with other authors. Between January 1978 and February 1993, we evaluated 101 patients with different clinical types of scleroderma 89 females and 12 males with ages between 16-83 (mean: 49, 19 years). In order to determine systemic sclerosis diagnosis following Masi Rodman criterion's we found from 101 cases 83 had dysphagia (82.2%) motor 66 (65%) organic 17 (34.7%) GER was seem in 41 cases (40.5%). According to Heitz's radiological classification: I: 26 patients (25%) II: 58 patients (52.4%) III: 19 patients (18.8%) IV: 17 patients (16.9%). In reference to Neschis manometric classification we found II 88 (76%) III 77 (76%) In accordance with endoscopical classification we found I: 16 (15.8%); II: 49 (48.5%); III: 19 (18.8%); IV: 17 (16.9%); Although this motor and organic oesophageal alterations have an evident diagnostic value, they have also been referred in another metabolic and collagen diseases but with lesser frequency than was found in the systemic sclerosis by us.
Assuntos
Doenças do Esôfago/etiologia , Escleroderma Sistêmico/complicações , Adolescente , Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-IdadeRESUMO
La esclerosis sistémica progresiva, es una colagenopatia con alta frecuencia de compromiso esofágico, especialmente si se utiliza la manometría como método de evaluación y que asume elevadas complicaciones clínicas en un alto porcentaje de pacientes. El objetivo fue evaluar la prevalencia del compromiso esofágico a través de la clínica, radiológia, endoscopia, manometría, y comparar los resultados con los de otros autores. Entre enero de 1978 y febrero de 1993, se evaluaron 101 pacientes con distintas formas clínicas de esclerodermia, 89 mujeres y 12 varones de edades entre 16 y 83 años, con X de 49,19 años. Para establecer el diagnóstico de esclerosis sistémica se tomaron en cuenta los criterios establecidos por Masi, Rodnan (1978). De los 101 casos, 83 tuvieron disfagia (82,2 por ciento), motora 66 (65 por cento) orgánica 17(34,7 por ciento). Reflujo gastroesofágico se observó en 41 casos (40,5 por ciento). Según la clasificación radiológica de Heitz: estadio I, 26 pacientes (25 por ciento), estadio II, 58 pacientes (57,4 por ciento), estadio III, 17 pacientes (16,9 por ciento). Endoscópicamente según Gibbs se encontraron: estadío I, 16 pacients (15,8 por ciento), estadío II 49 pacientes (48,5 por ciento), estadío III, 19 pacients (18,8 por ciento) y estadío IV, 17 pacientes (16,9 por ciento). Manometria, según Neschis, observamos 77 pacientes (76//) en estadío II y III. Si bien estas anormalidades motoras y orgánicas esofágicas tienen un valor diagnóstico evidente también han sido referidas en otras colagenopatías y enfermedades metabólicas, que aunque con frecuencia significativamente menor a la hallada por los autores en la esclerosis sistémica progresiva