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INTRODUCTION: Progressive supranuclear palsy is a disease that normally presents only sporadically in adults and courses in a progressive, chronic manner. It is characterised by the presence of supranuclear ophthalmoplegia, postural instability, a Parkinsonian syndrome, pseudobulbar affect, cervical dystonia and cognitive impairment. PATIENTS AND METHODS: We conducted a descriptive study of clinical and epidemiological features in a series of 18 patients who satisfied the mandatory NINDS-SPSP clinical eligibility criteria for the likely diagnosis of progressive supranuclear palsy, using the scale developed by Golbe et al. RESULTS AND CONCLUSIONS: The mean age of onset of the disease was 58.6 +/- 8.2 years, 55.5% of the patients were males, the average history of the disease at the time of diagnosis was 4.39 +/- 2.3 years, and there was a diagnostic subregister in the first 4 years of the disease. Gait disorders, falls and slowness were the most frequently observed presenting forms of the disease. During their first four years with the disease, 75% of the patients were totally independent when it came to carrying out activities of daily living, whereas after the fourth year there was a predominance of the need for aid and absolute dependence. Dysphagia was more frequent in the later stages of the disease. Ocular motility disorders and impaired cognitive functioning were obvious in the initial stages of the disease, and there was a strong correlation between the length of time the disease had been coursing and the severity of the ocular and cognitive disorders.

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The present design is a descriptive study in which people bitten by animals, rabies treatment used and the reactions to it are described. The frequency of adverse effects to the vaccine and to the serum are pointed out. The forms of clinical presentation and the clinical symptoms of the reactions observed in the Ciego de Avila province, Cuba, in the period from 1981 to 2001, were evaluated. In this period prevailed the reactions to the heterologous serum and the reactions caused by the human rabies vaccine. Local reactions to the vaccine were more common than the systemic ones. Four neuroparalytic reactions produced by the vaccines were observed. The most frequent symptoms and signs of the patients with reaction to the vaccine were pruritus, rash, localized urticaria, papule in the point of injection and local pain. The clinical manifestations considered as reactions to the heterologous serum that prevailed in the patients were rash in gluteal regions, pruritus, local erythyema and fever. No patient was detected with neurological manifestations caused by the heterologous serum.

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Se describen 2 casos de actinomicosis, uno podal y otro genital. El primero correspondió a una lesión en la planta del pie derecho de un paicente de 33 años de edad, con buena evolución clínica después de un tratamiento con ciprofloxacino y sin recidivas después de 2 años de observación. El segundo se registró en una paciente de 27 años de edad, que concurrió al servicio de ginecología dels hospital provincial Dr. Antonio Luaces Iraola de la provincia Ciego de Avila, Cuba. La pacientes después de noventa días de inicio del cuadro clínico, presenta un aumento de volumen en el abdomeninferior. Al ingreso se detectó palidez cutánea, pérdida de peso, tos no productiva y palpación de una masa tumoral. Se realizó ultrasonido abdominal y laparoscopía, observándose una masa sólida de gran tamaño de aproximadamente 10 cm. Se realizó investigación quirúrgica detectándose un gran plastrón que abarcaba útero, ambos anexos con asas intestinales y epiplón. Se confirmó actinmicosis genital por biopsia en anatomía patológica. La paciente falleció a los 7 días del postoperatorio por insuficiencia renal. (AU)

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