1.
J Chromatogr B Analyt Technol Biomed Life Sci
; 795(1): 141-4, 2003 Sep 25.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12957178
RESUMO
The aim of the present study was to develop a simple method to measure ranitidine, using 100 microL of plasma, by high-performance liquid chromatography with a Symmetry C(18) column and UV detection at 313 nm. Linearity was assessed in the range from 50 to 1500 ng ml(-1) and had a correlation coefficient of 0.999. The inter- and intra-day coefficients of variation were less than 7%. The limits of detection and quantitation were 5 and 15 ng ml(-1), respectively. Drug levels were determined satisfactorily in three patients. A simple and reliable method was developed which uses a microvolume of plasma, particularly useful in low-weight children.
Assuntos
Cromatografia Líquida de Alta Pressão/métodos , Antagonistas dos Receptores H2 da Histamina/sangue , Ranitidina/sangue , Humanos , Reprodutibilidade dos Testes , Espectrofotometria Ultravioleta/métodos
2.
Cochabamba; UMSS-Fac. Agronomía. TESIS; 1994. 136 ; 28 cm p. graf.
Tese
em Espanhol
| LIBOCS, LIBOSP
| ID: biblio-1334880