RESUMO

The critically ill patient, during the natural course of the disease often presents acid-base disturbances acidosis being the most common metabolic problem. Sodium bicarbonate has been used, for its correction but due to complications its use is restricted. In the present experimental study, mixed race dogs were artificially induced metabolic acidosis with in chloride acid. Arterial and venous blood gases were determined. Afterwards 0.1N sodium hydroxide was administered in the same amount statistically demonstrating modifications, in the pH values, as well as an excess of arterial and venous base which indicates the possibility of using this substance in humans to correct metabolic acidosis.

Assuntos

Acidose/tratamento farmacológico , Modelos Animais de Doenças , Hidróxido de Sódio/administração & dosagem , Acidose/induzido quimicamente , Acidose/epidemiologia , Análise de Variância , Animais , Cães , Avaliação Pré-Clínica de Medicamentos , Ácido Clorídrico , Concentração de Íons de Hidrogênio , Soluções