Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 1 de 1
Filtrar
Mais filtros











Base de dados
Intervalo de ano de publicação
1.
Auton Neurosci ; 159(1-2): 51-61, 2011 Jan 20.
Artigo em Inglês | MEDLINE | ID: mdl-20817619

RESUMO

In the present study the role of 5-HT(3) receptors located at the medial septum/vertical limb of the diagonal band complex (MS/vDB) in the control of blood pressure in unanaesthetized rats was investigated. Microinjections of ondansetron, a selective 5-HT(3) receptor antagonist, into this area caused a dose-dependent increase in blood pressure. This rise was attenuated by the blockade of alpha-adrenoceptors with i.v. prazosin and blunted by the prior microinjection of losartan, an AT1 antagonist, into this brain area. Microinjections of the 5-HT(3) agonist m-CPBG into this area failed to have any effect on blood pressure in non-stressed rats but significantly reduced the stress-induced hypertensive response. The reflex bradycardia evoked by i.v. phenylephrine was significantly increased after microinjections of ondansetron into this brain area but not the tachycardia evoked by i.v. sodium nitroprusside, suggesting that the pressor part of baroreflex has been enhanced. The data suggest that 5-HT(3) receptors at this brain level exert a tonic sympathoinhibitory action that is mediated via the local release of angiotensin in the MS/vDB. This tonic 5-HT(3) receptor drive also exerts an inhibitory action on the pressor component of the baroreflex. Also, the present data show that 5-HT(3) receptors located in the MS/vDB participate in the regulation of stress-induced hypertensive response.


Assuntos
Pressão Sanguínea/fisiologia , Hipertensão/fisiopatologia , Receptores 5-HT3 de Serotonina/metabolismo , Núcleos Septais/fisiologia , Antagonistas da Serotonina/farmacologia , Serotonina/metabolismo , Angiotensinas/metabolismo , Animais , Pressão Sanguínea/efeitos dos fármacos , Masculino , Inibição Neural/fisiologia , Prosencéfalo/metabolismo , Ratos , Ratos Wistar , Núcleos Septais/efeitos dos fármacos , Núcleos Septais/metabolismo , Regulação para Cima/fisiologia
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA