RESUMO
Heparin-induced thrombocytopenia (HIT) is immune-mediated. It occurs more frequently with unfractionated heparin (UFH) than with low molecular weight heparins (LMWH). It is associated with thromboembolic rather than hemorrhagic events, as opposed to thrombocytopenia of other etiologies. The key in therapy is the cessation of heparin and the start of another anticoagulant. We report a 58 years old female with HIT secondary to the use of Enoxaparin who was successfully managed with Rivaroxaban. Our goal is to report a novel therapy and provide the evidence that supports its use.
Assuntos
Humanos , Feminino , Pessoa de Meia-Idade , Trombocitopenia/induzido quimicamente , Trombocitopenia/tratamento farmacológico , Heparina/uso terapêutico , Inibidores do Fator Xa/uso terapêutico , Rivaroxabana/uso terapêutico , Anticoagulantes/efeitos adversos , Fatores de Risco , Resultado do Tratamento , Trombose Venosa/etiologia , Trombose Venosa/prevenção & controleRESUMO
Heparin-induced thrombocytopenia (HIT) is immune-mediated. It occurs more frequently with unfractionated heparin (UFH) than with low molecular weight heparins (LMWH). It is associated with thromboembolic rather than hemorrhagic events, as opposed to thrombocytopenia of other etiologies. The key in therapy is the cessation of heparin and the start of another anticoagulant. We report a 58 years old female with HIT secondary to the use of Enoxaparin who was successfully managed with Rivaroxaban. Our goal is to report a novel therapy and provide the evidence that supports its use.
Assuntos
Anticoagulantes/efeitos adversos , Inibidores do Fator Xa/uso terapêutico , Heparina/efeitos adversos , Rivaroxabana/uso terapêutico , Trombocitopenia/induzido quimicamente , Trombocitopenia/tratamento farmacológico , Feminino , Humanos , Pessoa de Meia-Idade , Fatores de Risco , Resultado do Tratamento , Trombose Venosa/etiologia , Trombose Venosa/prevenção & controleRESUMO
Background: Cat-scratch disease is common among children. Among adults the disease is less often considered in the differential diagnosis of enlarged lymph nodes and fever. Aim: To report the clinical and laboratory features of eight patients with cat-scratch disease. Material and methods: Review of the medical records of eight patients (aged 22 to 57 years, six males) with a serological diagnosis of cat-scratch disease (an IgG titer over 1:256, by immunofluorescence). Results: Only five patients recalled having had contact with cats. Seven had fever and weight loss. Six had excessive sweating and five had chills. Seven had painfully enlarged lymph nodes mainly in submandibular and axillary regions. All had an increased C reactive protein and six had elevated erythrocyte sedimentation rate. Five had leukocytosis and four an elevated serum lactate dehydrogenase. The disease subsided in all, even in one patient that did not receive antimicrobials. Conclusions: Cat-scratch disease should be considered in the differential diagnosis of adult patients with lymph adenitis and fever.