RESUMO
In this study, we revealed that OA and UA significantly inhibited the expression of most genes related to peptidoglycan biosynthesis in S. mutans UA159. To the best of our knowledge, this is the first report to introduce the antimicrobial mechanism of OA and UA against S. mutans.
Assuntos
Antibacterianos/farmacologia , Vias Biossintéticas/efeitos dos fármacos , Vias Biossintéticas/genética , Ácido Oleanólico/farmacologia , Peptidoglicano/biossíntese , Streptococcus mutans/efeitos dos fármacos , Triterpenos/farmacologia , Regulação Bacteriana da Expressão Gênica/efeitos dos fármacos , Ácido UrsólicoRESUMO
In this study, we revealed that OA and UA significantly inhibited the expression of most genes related to peptidoglycan biosynthesis in S. mutans UA159. To the best of our knowledge, this is the first report to introduce the antimicrobial mechanism of OA and UA against S. mutans.
Assuntos
Antibacterianos/farmacologia , Vias Biossintéticas/efeitos dos fármacos , Vias Biossintéticas/genética , Ácido Oleanólico/farmacologia , Peptidoglicano/biossíntese , Streptococcus mutans/efeitos dos fármacos , Triterpenos/farmacologia , Regulação Bacteriana da Expressão Gênica/efeitos dos fármacosRESUMO
In this study, we revealed that OA and UA significantly inhibited the expression of most genes related to peptidoglycan biosynthesis in S. mutans UA159. To the best of our knowledge, this is the first report to introduce the antimicrobial mechanism of OA and UA against S. mutans.(AU)