RESUMO
UNLABELLED: After intracoronary platelet aggregation, malondialdehyde (MDA), a lipid peroxide product is released. MDA renders some lipoproteins more atherogenic. OBJECTIVE: The objective of this study was to determine the sanguineous concentration of MDA in patients with type 2 diabetes mellitus (DM2) and patients with coronary disease. We measured methods and material MDA in plasma of 131 consecutive normal subjects, 44 hyperlipidemic, hyperglycemic patients with type 2-diabetes mellitus (DM2), 60 normolipidemic patients with angina, and 62 normolipidemic patients with acute myocardial infarction with and without DM2. STATISTICAL ANALYSIS: The concentration of MDA was lowest in normal subjects (42.5 +/- 7.2 micrograms per deciliter), intermediate in those with DM2 (62.7 +/- 10.1 micrograms per deciliter, p < 0.002), and highest in those with myocardial infarction (101.6 +/- 31.7 micrograms per deciliter, p < 0.001). The mean MDA concentration of patients with infarction was similar to that of patients with angina (121.8 +/- 51.9 micrograms per deciliter, p < 0.07). Stepwise logistic regression analysis showed that MDA was a possible predictor of myocardial infarction. CONCLUSIONS: The increase of plasma MDA might be a biochemical marker of coronary artery disease. We suggest that MDA levels greater than 62.7 micrograms per deciliter could indicate a high risk for myocardial infarction.
Assuntos
Doença das Coronárias/sangue , Diabetes Mellitus Tipo 2/sangue , Malondialdeído/sangue , Infarto do Miocárdio/sangue , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Glicemia/análise , Feminino , Humanos , Masculino , Pessoa de Meia-IdadeRESUMO
It is as if the embryo has learnt to foil the maternal inflammatory/immune system. Acting through trophoblastic protein-1, the conceptus inhibits prostaglandin F-2a synthesis and thereby prolongs corpus luteum survival. In addition, that protein (an interferon variant), suppresses T cell proliferation. Other interferons (b and g), prostaglandin E-2 and progesterone, synthesized by trophoblast and decidua, act in concert to help the embryo to elude the aggression of the immune system. Failure of these mechanisms leads to reactivation of maternal killer T cells, mononuclear infiltration in the conceptus and its demise.
Assuntos
Decídua/imunologia , Trofoblastos/imunologia , Embrião de Mamíferos/imunologia , Feminino , Humanos , Imunidade , GravidezRESUMO
Silver-staining of the nucleolus organizer region, which represents transcription of ribosomal ribonucleic acid genes, was herein studied in the acrocentric chromosomes of a patient with premature ovarian failure. The demonstration of an additional nucleolar organizer region in the peripheral lymphocytes, suggests a causal relationship between transcriptive activity and this type of ovarian failure.
Assuntos
Região Organizadora do Nucléolo , Insuficiência Ovariana Primária/genética , Adulto , Cromossomos Humanos , Feminino , Humanos , Recém-Nascido , Pessoa de Meia-Idade , Gravidez , RNA Ribossômico , Coloração pela Prata , Transcrição GênicaRESUMO
An improvement of the silver-staining method of the nucleolus organizer region with simultaneous trypsin-Giemsa-banding is described. The combined demonstration of such regions (which express the transcriptive activity of ribosomal ribonucleic acid genes) and the precise identification of chromosomes, particularly acrocentric chromosomes, should be of value in the investigation of parents with spontaneous abortion in whom abnormal acrocentric chromosomes are often encountered.
Assuntos
Bandeamento Cromossômico , Citogenética , Região Organizadora do Nucléolo , Obstetrícia , RNA Ribossômico , Adulto , Corantes Azur , Feminino , Humanos , Gravidez , RibossomosRESUMO
Over the past decade the study of Interleukins and Interferons has advanced from functional descriptions to detailed structural understanding. The ability of these growth factors to act, directly or through immune mechanisms on the pancreatic beta-cell and to affect in vitro and in vivo both its morphology and physiology, indicate that they may play a role in the pathogenesis and prevention of insulin-dependent diabetes mellitus. Also, the relation between these cytokines-constitutive or upon stimulation maybe useful to predict the development of diabetes mellitus.
Assuntos
Diabetes Mellitus/imunologia , Interferon gama/fisiologia , Interleucinas/fisiologia , Ilhotas Pancreáticas/imunologia , Fator de Necrose Tumoral alfa/fisiologia , HumanosRESUMO
The subject of endometrial epithelial growth control by the cytokine system has been scantily addressed in the literature. This article analyses the effects of cytokines on the endometrium in order to improve our understanding regarding the autocrine, paracrine and systemic mechanisms that govern cell differentiation and tumor formation in human endometrial epithelial cells.
Assuntos
Endométrio/crescimento & desenvolvimento , Interferons/fisiologia , Interleucinas/fisiologia , Transformação Celular Neoplásica/metabolismo , Neoplasias do Endométrio/etiologia , Neoplasias do Endométrio/fisiopatologia , Epitélio/crescimento & desenvolvimento , Feminino , Humanos , Fator de Necrose Tumoral alfa/fisiologiaRESUMO
El estudio ultraestructural de nueve especimenes quirurgicos de glandulas paratiroides obtenidos de nueve pacientes con hiperparatiroidismo primario (cinco adenomas de celulas principales y cuatro con hiperplasia de celulas principales) demostro, en un caso de hiperplasia de celulas principales, redundancia de la lamina basal. Este hallazgo morfologico no previamente descrito debe interpretarse como una reaccion del epitelio a un estimulo desconocido. Se comenta en esta comunicacion la posibilidad de que la hormona paratiroidea participe en el desarrollo de esta alteracion de la lamina basal, asi como la ausencia coincidente de fibrillas interlaminares en la lamina basal y de material amiloide en la hiperplasia de celulas principales de la glandula paratiroides
Assuntos
Adulto , Humanos , Feminino , Amiloide , Hiperplasia , Glândulas ParatireoidesRESUMO
A case of testicular feminization syndrome associated with lymphoma is reported. This association has not been previously described. We mentioned an hypothesis about this association.
Assuntos
Síndrome de Resistência a Andrógenos/complicações , Linfoma/complicações , Adulto , Síndrome de Resistência a Andrógenos/patologia , Biópsia , Humanos , Linfonodos/patologia , Linfócitos , Linfoma/patologia , Masculino , Testículo/patologiaRESUMO
This paper reports the association of diabetes mellitus and hyperlipidemia type III and the relation between the dose of insulin and the serum level of triglycerides and cholesterol. The coexistence of hiperglobulinemia, Bence Jones proteinuria and a positive rheumatoid factor is also reported.