RESUMO
Serial retinal examinations were performed in children aged 5 years and older and fluorescein angiography/angioscopy in children 6 years and older participating in a cohort study of sickle cell disease. There were 1229 patient years of observation among 389 children aged 5 - 13 years. Peripheral retinal vessel closure was present in approximately 50 percent of children with SS and SC genotypes at age 6 years and increased to affect 90 percent of children by age 12 years. A matched pair analysis, comparing groups with minimal and complete closure, indicated that complete closure was associated with significantly lower total haemoglobin and fetal haemoglobin levels and significantly lower weight in SS disease, whereas in SC disease the risk factors appeared to be high mean cell volume and low platelet count. Proliferative retinopathy was rare, occurring only once in an 8-year-old boy with SC disease, despite 592 patient years of observation in children over this age. (AU)
Assuntos
Humanos , Pré-Escolar , Criança , Adolescente , Masculino , Feminino , Anemia Falciforme/epidemiologia , Doenças Retinianas/epidemiologia , Fatores Etários , Peso Corporal , Estudos de Coortes , Hemoglobina Fetal/análise , Angiofluoresceinografia , Hematócrito , Hemoglobinas/análise , Jamaica , Fatores de Risco , Acuidade VisualRESUMO
Opthalmic assessment was performed on a random sample of 178 black Jamaican diabetics. Retinopathy was present in 69 percent. Severe visual loss (V.A.<5/200or