RESUMO

Circular RNAs (circRNAs) are circularized single-stranded ribonucleic acids that interacts with DNA, RNA, and proteins to play critical roles in cell biology. CircRNAs regulate microRNA content, gene expression, and may code for specific peptides. Indeed, circRNAs are differentially expressed in neurodegenerative disorders like Parkinson's disease (PD), playing a potential role in the mechanisms of brain pathology. The RNA molecules with aberrant expression in the brain can cross the blood-brain barrier and reach the bloodstream, which enable their use as non-invasive PD disease biomarker. Promising targets with valuable discriminatory ability in combined circRNA signatures include MAPK9_circ_0001566, SLAIN1_circ_0000497, SLAIN2_circ_0126525, PSEN1_circ_0003848, circ_0004381, and circ_0017204. On the other hand, regular exercises are effective therapy for mitigating PD symptoms, promoting neuroprotective effects with epigenetic modulation. Aerobic exercises slow symptom progression in PD by improving motor control, ameliorating higher functions, and enhancing brain activity and neuropathology. These improvements are accompanied by changes circRNA expression, including hsa_circ_0001535 (circFAM13B) and hsa_circ_0000437 (circCORO1C). The sensitivity of current methods for detecting circulating circRNAs is considered a limitation. While amplification kits already exist for low-abundant microRNAs, similar kits are needed for circRNAs. Alternatively, the use of digital PCR can help overcome this constraint. The current review examines the potential use of circRNAs as non-invasive biomarkers of PD and to assess the effects of rehabilitation. Although circRNAs hold promise as targets for PD diagnosis and therapeutics, further validation is needed before their clinical implementation.

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RESUMO

This study had as objective to correlate the resistance of the carotid artery and the functional autonomy of old women. The resistance of the carotid artery was evaluated through the method called Doppler and the functional autonomy through tests related to daily activities (Protocol GDLAM). In the description of the data it was used measures of localization and dispersion. The internal right carotid resistance got mean and pattern deviation respectively (0.71 +/- 0.07) and functional autonomy mean and pattern deviation respectively (30.40 +/- 6.31). The coefficient of the correlation of Spearman showed a strong association between the variation of the study (r = 0.998; p = 0.000). The results suggest that the bigger the table of contents of the resistance of the carotid artery is the bigger will be the difficulty of execution of the daily life tasks.

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RESUMO

Este estudo objetivou correlacionar resistência da artéria carótida e autonomia funcional de idosas. Avaliou-se a resistência da artéria carótida pelo método de ultra-som Doppler e a Autonomia Funcional por testes relacionados a atividades da vida diária (Protocolo GDLAM). Para a descrição dos dados, calculou-se média e desvio padrão, em que a resistência da carótida interna direita obteve respectivamente (0,71 ± 0,07) e o Índice geral de Autonomia Funcional apresentou (30,40 ± 6,31). O coeficiente de correlação de Spearman mostrou forte associação entre as variáveis do estudo (r = 0,998; p = 0,000). Os resultados sugerem que quanto maior o índice de resistência da artéria carótida, maior será a dificuldade de execução das tarefas da vida diária.

This study had as objective to correlate the resistance of the carotid artery and the functional autonomy of old women. The resistance of the carotid artery was evaluated through the method called Doppler and the functional autonomy through tests related to daily activities (Protocol GDLAM). In the description of the data it was used measures of localization and dispersion. The internal right carotid resistance got mean and pattern deviation respectively (0,71 ± 0,07) and functional autonomy mean and pattern deviation respectively (30,40 ± 6,31). The coefficient of the correlation of Spearman showed a strong association between the variation of the study (r = 0,998; p = 0,000). The results suggest that the bigger the table of contents of the resistance of the carotid artery is the bigger will be the difficulty of execution of the daily life tasks.

Este estudio objetivou correlacionar resistência de la arteria carótida interna derecha Y autonomía funcional de ancianas. Se evaluó la resistência de la arteria carótida por el método de ultra-sonido Doppler e a autonomia funcional a través de testes relacionados la actividad da vida diaria (Protocolo GDLAM). Em la descripción de los datos, se calculou media y desvío padrón, donde la resistência de la arteria carótida interna derecha tuvo respectivamente (0,71 ± 0,07) y em lo índice geral de la autonomía funcional fueron respectivamente (30,40 ± 6,31). Lo coeficiente de la correlación de Spearman mostrou fuerte associación entre las variables de el estudio (r = 0,998; p = 0,000). Los resultados sugerem que cuanto mayor lo índice de la resistência de la arteria carótida, mayor fuerón las dificuldades de execucusión de las actividad de la vida diaria.

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O presente trabalho foi realizado através da seleção de um individuo idoso portador de osteoartrite de joelho, no qual foram utilizados para confirmação da patologia o diagnóstico médico, o exame radiológico e a sintomatologia clínica. Foram realizados um total de 36 sessões de fisioterapia exclusivamente de alongamento estático e fortalecimento excêntrico do quadríceps femoral, com freqüência de três sessões por semana, com duração média de 50 minutos cada sessão. Foram utilizadas as escalas de força manual, goniometria passiva, perimetria, índice algo-funcional de Lequesne e escala de Cincinnati, para mensuração, com obtenção de ganhos significativos, demonstrados em forma de grá. cos. Devemos considerar que apesar de haverem possíveis variáveis nesta pesquisa por ter sido realizada somente com uma amostra, concluímos que o exercício excêntrico de quadríceps femoral produz uma melhora substancial no quadro álgico e incapacitante em indivíduos portadores de osteoartrite de joelho, resultando em uma melhor qualidade de vida.

The current work was performed through the selection of an elderly individual with knee osteoarthritis, confirmed by medical diagnostic, radiology examination, and clinical symptoms. A total of 36 physical therapy sessions exclusively of static stretching and eccentric strengthening of the femoral quadriceps were performed, with a frequency of three sessions per week, with an average duration of 50 minutes each session. The manual force scales, the passive goniometry, perimetry, Lequesne index and Cincinnati scale used for mensuration with significant gains, shown in graphs were also performed. We should consider that although there might be possible variables in this research, since it was performed only with one person, we concluded that the eccentric exercise of femoral quadriceps produces a substantial improvement in the algic and disability process in patients with knee osteoarthritis, resulting in a better quality of life.

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Este artigo tem como objetivo esclarecer os resultados de um estudo quantitativo de marcha, realizado com dez idosos institucionalizados escolhidos aleatoriamente, dando prioridade á cadencia, á amplitude de passos á direita e a esquerda, á amplitude da passada e a largura da passada. As fases e subfases da marcha tambem foram observadas, contudo, com menos ênfase. Os resultados obtidos sao relevantes, á medida que fornecem uma visao geral de como estes idosos locomovem-se na instituicao e como a sua marcha é alterada em relaçao ás pessoas mais jovens.

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