RESUMEN
BACKGROUND: We report the case of a road worker with a food allergy to banana, who developed urticaria and rhinitis when cutting shrubs of Ficus benjamina and breadfruit. He did not develop an allergy to latex of Hevea brasiliensis. RESULTS: Sensitization to latex of F. benjamina, H. brasiliensis, breadfruit and banana was demonstrated using skin tests and specific IgE measurements. RAST inhibitions procedures showed that specific IgE to breadfruit latex cross-reacted more strongly with latex of H. brasiliensis and banana than with latex of F. benjamina with the same extract. CONCLUSION: Given the wide distribution of Moracea trees in tropical regions, sensitization to latex of H. brasiliensis and banana could be a consequence of sensitization to Moracea members; F. benjamina does not seem to be the only Moracea responsible for cross-allergy with latex and fruit. Consequently, it seems interesting to test other members of the Moracea family in patients sensitized to latex of H. brasiliensis and banana. Sensitization to breadfruit could be a risk factor for sensitization to latex of H. brasiliensis.
Asunto(s)
Hipersensibilidad a los Alimentos/inmunología , Frutas/efectos adversos , Hipersensibilidad al Látex/inmunología , Enfermedades Profesionales/inmunología , Plantas/efectos adversos , Rinitis Alérgica Perenne/inmunología , Urticaria/inmunología , Zingiberales/efectos adversos , Adulto , Angioedema/etiología , Angioedema/inmunología , Reacciones Cruzadas , Dermatitis Profesional/etiología , Dermatitis Profesional/inmunología , Hipersensibilidad a los Alimentos/etiología , Frutas/inmunología , Humanos , Inmunoglobulina E/inmunología , Látex/inmunología , Hipersensibilidad al Látex/epidemiología , Masculino , Martinica , Enfermedades Profesionales/etiología , Plantas/inmunología , Prueba de Radioalergoadsorción , Rinitis Alérgica Perenne/etiología , Factores de Riesgo , Pruebas Cutáneas , Árboles/inmunología , Urticaria/etiología , Zingiberales/inmunologíaRESUMEN
Comunicamos 6 casos de telangiectasia macularis eruptiva perstans, forma de mastocitosis cutánea de rara observación en la casuística nacional e internacional. Exponemos el hallazgo inusual de compromiso facial, con la presencia de lesiones maculosas y telangiectásicas en dos de los pacientes, así como la ausencia de dermografismo y signo de Darier en todos los casos, hechos que motivaron la presentación de este trabajo. Se efectúa una revisión de las características de la mastocitosis y de distintas clasificaciones de la misma. Se destaca el valor relativo del aumento del número de mastocitos en el estudio histológico de esta entidad
Asunto(s)
Humanos , Masculino , Femenino , Adulto , Persona de Mediana Edad , Degranulación de la Célula , Mastocitos/efectos de los fármacos , Mastocitosis/clasificación , Medios de Contraste/efectos adversos , Erupciones por Medicamentos/patología , Frutas/efectos adversos , Compuestos de Yodo/efectos adversos , Mastocitos/fisiología , Mastocitosis/diagnóstico , Mastocitosis/terapia , Productos de la Carne/efectos adversos , Educación del Paciente como Asunto , Factores Desencadenantes , Telangiectasia/etiología , Zingiberales/efectos adversosRESUMEN
Comunicamos 6 casos de telangiectasia macularis eruptiva perstans, forma de mastocitosis cutánea de rara observación en la casuística nacional e internacional. Exponemos el hallazgo inusual de compromiso facial, con la presencia de lesiones maculosas y telangiectásicas en dos de los pacientes, así como la ausencia de dermografismo y signo de Darier en todos los casos, hechos que motivaron la presentación de este trabajo. Se efectúa una revisión de las características de la mastocitosis y de distintas clasificaciones de la misma. Se destaca el valor relativo del aumento del número de mastocitos en el estudio histológico de esta entidad (AU)
Asunto(s)
Humanos , Masculino , Femenino , Adulto , Persona de Mediana Edad , Mastocitosis/clasificación , Degranulación de la Célula/efectos de los fármacos , Mastocitos/efectos de los fármacos , Mastocitosis/diagnóstico , Mastocitosis/terapia , Factores Desencadenantes , Mastocitos/fisiología , Educación del Paciente como Asunto , Telangiectasia/etiología , Productos de la Carne/efectos adversos , Compuestos de Yodo/efectos adversos , Medios de Contraste/efectos adversos , Zingiberales/efectos adversos , Frutas/efectos adversos , Erupciones por Medicamentos/patologíaRESUMEN
Alguns alimentos têm sido apontados como fatores deflagadores alimentares das crises de migrânea. Frutas cítricas como laranja e limäo säo particularmente reconhecidos como deflagadores de migrânea. Banana foi sugerida no passado mas näo houve provas de que realmente precipitava um episódio de migrânea. O objetivo deste estudo foi o de avaliar a ingestäo de banana como um fator deflagrador alimentar de uma crise de migrânea. Foram estudados retrospectivamente 616 pacientes, 112 homens e 504 mulheres com o diagnóstico migrânea de acordo com os critérios da Sociedade Internacional de Cefaléias. A banana foi considerada como um fator preciptador de um ataque de migrânea, quando o paciente referiu que a sua ingestäo trouxe claramente um ataque dentro de 6 horas, pelo menos em duas ocasiöes. 138 pacientes (22,4 por cento) relataram que pelo menos dois episódios de migrânea foram iniciados dentro de 6 horas após a ingestäo de no mínimo 1 banana. Interessantemente, 96 pacientes (69,5 por cento) reportaram que somente um tipo específico de banana, conhecido como banana d`água, foi o responsável pelo início dos ataques. Em conclusäo, a banana, principalmente um tipo denominado de banana d`água, foi claramente responsabilizada como um fator deflagrador de crises de migrâneas por 22,4 por cento de uma populaçäo de 616 migranosos. Estudos controlados, utilizando uma metodologia duplo-cega e cruzada, säo necessários para confirmar estas observaçöes
Asunto(s)
Humanos , Masculino , Femenino , Cefalea/etiología , Factores Desencadenantes , Zingiberales/efectos adversosRESUMEN
The use of herbal medicine is widespread and growing, with as many as 3 in 10 Americans using botanical remedies in a given year. Because many herbal medicines have significant pharmacological activity, and thus potential adverse effects and drug interactions, healthcare professionals must be familiar with this therapeutic modality. This article summarizes the history and current use of plant-based medicine and highlights the evidence of the risks and benefits associated with 6 plants: echinacea, garlic, ginger, ginkgo, St John's wort, and valerian. Therapies outside the medical mainstream tend to suffer from a dearth of research and critical evaluation. Critics and supporters alike note the conceptual and practical difficulties in studying many complementary and alternative therapies such as acupuncture, homeopathy, and meditation. Herbal medicine, however, lends itself well to standard evaluation methods. This article summarizes and evaluates evidence from randomized controlled trials and meta-analyses. We present the results of meta-analyses and subsequent randomized controlled trials for garlic and St John's wort; a comprehensive critical review and subsequent randomized controlled trials for ginkgo; and summaries of all identified randomized controlled trials for echinacea, ginger, and valerian.
Asunto(s)
Plantas Medicinales/efectos adversos , Ericales/efectos adversos , Ajo/efectos adversos , Ginkgo biloba/efectos adversos , Humanos , Extractos Vegetales/efectos adversos , Medición de Riesgo , Valeriana/efectos adversos , Zingiberales/efectos adversosRESUMEN
BACKGROUND: Banana allergy has been associated with the latex-fruit syndrome. Several IgE-binding components, the relevant ones being proteins of 30-37-kDa, have been detected in banana fruit, but none of them have been isolated and characterized yet. Objective To purify and characterize the 30-37 kDa banana allergens. METHODS: Fifteen patients allergic to banana were selected on the grounds of a latex-allergic population. Prick by prick tests to this fruit were performed. Total and specific IgE to banana were determined. Banana allergens were isolated by affinity chromatography, followed by cation-exchange chromatography. Their characterization includes N-terminal sequencing, enzymatic activity assays, immunodetection with sera from allergic patients and with antichitinase antibodies, and CAP and immunoblot inhibition tests. Skin prick tests with banana extracts and with the purified allergens were also carried out. RESULTS: Two major IgE-binding proteins of 34 and 32 kDa, also recognized by polyclonal antibodies against chestnut chitinases, were immunodetected in crude banana extracts. Purification and characterization of both proteins have allowed their identification as class I chitinases with an hevein-like domain. Each isolated allergen reached inhibition values higher than 90% in CAP inhibition assays, and fully inhibited the IgE-binding by the crude banana extract when tested by an immunoblot inhibition method. The two purified allergens provoked positive skin prick test responses in more than 50% of the banana-allergic patients. CONCLUSIONS: Class I chitinases with an hevein-like domain are major allergens in banana fruit. Their presence in other fruits and nuts, such as avocado and chestnut, could explain the cross-sensitization among these foods.