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The intravenous injection of cimetidine in a dose of 20 mg/kg enhanced verografine and iodamide excretion in chronic canine experiments. The higher verografine and iodamide excretion was due to their increased renal tubular secretion. In dogs, cimetidine unchanged the secretion of cardiotrast, a test agent for anionic transport. Possible extrarenal mechanisms of action of cimetidine on verografine and iodamide transport were also examined.

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Administration of cardiotrast (50-80 mg twice a day subcutaneously) during pregnancy was shown to induce a significant suppression of tubular secretion of the xenobiotic in the offspring. When cardiotrast was given only in the postnatal period, tolerance failed to develop.

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A new inducer of the monooxygenase system zixoryn (oral dose--100 mg/kg, for 4 days) increased the excretion and maximum tubular transport of cardiotrast (diodrast) in rats. Zixoryn had no effect on daily and water diuresis and renal excretion of sodium, potassium and creatinine.

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I. v. infusion of dopamine increased diuresis, glomerular filtration rate, maximal reabsorption of glucose and tubular secretion of cardiotrast. Infusion of dopamine into the renal artery did not affect glomerular filtration rate and tubular secretion of cardiotrast while maximal reabsorption rate of glucose was increased. Dopamine exerted some direct effect on the transport of glucose, which effect can be blocked with haloperidol.

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Vinblastin or copper chloride inhibiting the microtubules, decrease tubular excretion of cardiotrast in rats. After incubation of the kidney tissue homogenat at pH 9.0 the augmentation of inorganic phosphate was more obvious in rats preliminarily injected with cardiotrast. The data obtained indicate the possible role of microtubules in the tubular secretion of organic substances and the participation of phosphorylation in this process.

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Single injection of insulin (1 AU/kg) enhanced maximal glucose absorption, cardiotrast secretion and decreased sodium excretion without any changes of glomerular filtration in dogs. These effects depended on the direct action of insulin so far as the effect is expressed in the kidney only at the side of infusion when the preparation is administered into one of the renal arteries. Prednisolone had no significant effect on the glucose and cardiotrast transport in single injection (3--4 mg/kg) and 10-day (1.5--2 mg/kg daily) injections.

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Effects of intrarenal infusion of potassium cyanide and strophanthinum were studied in acute experiments on dogs. The decrease fractional of reabsorption of sodium to 80--82 per cent did not affect renal reabsorption of glucose and tubular excretion of cardiotrast. Combined infusion of strophanthinum and cyanide decreased the fractional sodium reabsorption to 65.6 per cent. During this period maximal reabsorption of glucose reduced but not so the tubular excretion of cardiotrast.

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Following a protracted introduction of dichlothiazide to rats (20 mg/kg) and to dogs (5 mg/kg) there occurs a marked increase in the tubular secretion of the cardiotrast and passage of urates with urine. A single and long-term administration of the drug to dogs did not have any substantial effect on the maximal reabsorption of glucose.

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The influence of furosemide on the maximal glucose reabsorption, cardiotrast secretion and urate excretion was studied in chronic experiment. Single injection of furosemide increased the maximal glucose reabsorption in dogs. Thesere was no alteration in the secretory cardiotrast transport in response to the drug administration. Furosemide administration produced an uricosuric action in dogs and rats.

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Interaction of renal cardiotrast, glucose and urate transport was investigated in dogs in chronic experiments. There was no alteration in the maximum secretion of cardiotrast and in the malximum glucose reabsorption during simultaneous injection of cardiotrast and glucose. It was also shown that with the maximum saturation of the renal secretory and reabsorption transport there was no significant change in the urate excretion. The data obtained pointed to a possibility of combined administration of cardiotrast and glucose solutions with simultaneous determination of values of maximum cardiotrast secretion, maximum glucose reabsorption and urate excretion.

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Chronic experiments on dogs and rats showed retabolil, an anabolic steroid (given in a dose of 2-5 mg/kg for 7 days) to produce an increase in renal tubular secretion of cardiotrast. Rats displayed a simultaneous elevation in the content of protein and RNA in the kidney cortex. The data obtained were interpreted from the aspect of protein nature of carriers taking part in the renal secretory transport.

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