RESUMEN
ABSTRACT Objective: To report the use of virtual reality (VR) in pain intensity during dressing change of two burned children hospitalized in a Burn Treatment Center (BTC) in Southern Brazil. Method: Case report on the use of VR during dressing change of two burned children hospitalized in a BTC, from May to July 2016. For assessing pain, a facial pain rating scale was applied at four times: just before the dressing, during the dressing without the use of VR, during the dressing with the VR, and after the use of VR. Results: The use of goggles was easy to apply and well-accepted by the children, and also had a relevant effect reducing pain. Conclusion: VR can become an important nonpharmacological method for treating pain in burned children.
RESUMEN Objetivo: Relatar la utilización de la Realidad Virtual (RV) en disminución de intensidad del dolor durante cambio de vendajes de dos niños quemados, internados en un Centro de Tratamiento del Quemado (CTQ) del Sur de Brasil. Método: Relato de caso de utilización de RV durante cambio de vendajes de dos niños quemados internados en CTQ, de mayo a julio de 2016. Se evaluó el dolor utilizando escala numérica conjuntamente con la de faces, aplicándosela en cuatro momentos: inmediatamente antes del vendaje, durante el vendaje sin utilizar la RV, durante el vendaje utilizando RV y luego de la utilización de la RV. Resultado: El uso de los visores fue simple y bien recibido por los niños; además, hubo efectos relevantes en relación a la disminución del dolor. Conclusión: La RV puede constituir un importante método no farmacológico para el tratamiento del dolor en niños quemados.
RESUMO Objetivo: Relatar a utilização da Realidade Virtual (RV) na diminuição da intensidade dolorosa durante a troca de curativo de duas crianças queimadas internadas em um Centro de Tratamento ao Queimado (CTQ) do Sul do Brasil. Método: Relato de caso da utilização da RV durante a troca de curativos de duas crianças queimadas internadas em um CTQ, de maio a julho de 2016. Para avaliar a dor, foi utilizada escala numérica sobreposta à de faces, sendo aplicada em quatro momentos: imediatamente antes do curativo, durante o curativo sem uso da RV, durante o curativo com a RV e após a utilizaçãoda RV. Resultado: O uso dos óculos foi de fácil aplicação e bem aceito pelas crianças, além disso houce efeitos relevantes em relação à diminuição da dor. Conclusão: A RV pode se tornar um importante método não farmacológico no tratamento da dor em crianças queimadas.
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Humanos , Masculino , Niño , Vendajes/efectos adversos , Quemaduras/terapia , Manejo del Dolor/normas , Realidad Virtual , Pediatría/métodos , Pediatría/normas , Pediatría/estadística & datos numéricos , Brasil , Unidades de Quemados/organización & administración , Unidades de Quemados/estadística & datos numéricos , Manejo del Dolor/métodosRESUMEN
OBJECTIVE: To report the use of virtual reality (VR) in pain intensity during dressing change of two burned children hospitalized in a Burn Treatment Center (BTC) in Southern Brazil. METHOD: Case report on the use of VR during dressing change of two burned children hospitalized in a BTC, from May to July 2016. For assessing pain, a facial pain rating scale was applied at four times: just before the dressing, during the dressing without the use of VR, during the dressing with the VR, and after the use of VR. RESULTS: The use of goggles was easy to apply and well-accepted by the children, and also had a relevant effect reducing pain. CONCLUSION: VR can become an important nonpharmacological method for treating pain in burned children.
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Vendajes/efectos adversos , Quemaduras/terapia , Manejo del Dolor/normas , Realidad Virtual , Brasil , Unidades de Quemados/organización & administración , Unidades de Quemados/estadística & datos numéricos , Niño , Humanos , Masculino , Manejo del Dolor/métodos , Pediatría/métodos , Pediatría/normas , Pediatría/estadística & datos numéricosRESUMEN
AIMS AND OBJECTIVES: To investigate whether the type of dressing used (occlusive vs. semi-occlusive) impacts on exit-site infection. BACKGROUND: The exit-site infections are a major predisposing factor for peritoneal dialysis-related peritonitis, the main cause of technique failure and an important cause of mortality. The care taken in exit-site dressing is considered an important procedure for the prevention of trauma and contamination of this area. Nevertheless, to our knowledge, no study has yet analysed the impact of different dressing types on early exit-site infection (up to two months after catheter insertion). DESIGN: A prospective observational study involving the BRAZPD II (Brazilian Peritoneal Dialysis Multicenter Study) cohort. METHODS: All incident patients with data available for dressing type applied following peritoneal dialysis catheter insertion were included in the study. A multilevel logistic regression model was used to compare the log-odds of exit-site infections between groups. RESULTS: A total of 2460 incident patients were included. Occlusive and semi-occlusive dressings were applied in 82·6% (n = 2031) and 17·4% (n = 427) of patients, respectively. Exit-site infection incidence was not affected by the type of dressing used, with a logit for occlusive dressing of 2·15 (95% CI 0·81-5·70). The combined outcome of exit-site infection and tunnel infection also showed no significance between the groups (logit 1·46, 95% CI 0·72-2·97). CONCLUSION: Our results indicate that the type of exit-site dressing used during the healing phase following peritoneal dialysis catheter insertion has no impact on early exit-site infection rates. RELEVANCE TO CLINICAL PRACTICE: Provides evidence to support the similarity between occlusive and semi-occlusive dressing regarding infection rates in exit site of peritoneal dialysis catheter, therefore allowing the choice to be made accordingly to routine or availability.
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Vendajes/efectos adversos , Cateterismo/efectos adversos , Diálisis Peritoneal/efectos adversos , Infección de la Herida Quirúrgica/etiología , Adulto , Anciano , Brasil/epidemiología , Cateterismo/enfermería , Catéteres de Permanencia/efectos adversos , Femenino , Humanos , Incidencia , Masculino , Persona de Mediana Edad , Peritonitis/prevención & control , Estudios Prospectivos , Infección de la Herida Quirúrgica/epidemiología , Infección de la Herida Quirúrgica/prevención & controlRESUMEN
Os retalhos interpolados têm sido um dos mais importantes e funcionais retalhos no arsenal da cirurgia plástica reconstrutiva, tornando-se uma opção segura mesmo nos casos mais difíceis. O pedículo do retalho interpolado necessita de curativo para evitar sangramento e a contaminação local. Este curativo frequentemente falha na prevenção de pequenos sangramentos que ocorrem durante as primeiras 24-48 horas, forçando a troca recorrente do mesmo, em média de três a cinco trocas. A técnica proposta neste trabalho consiste na aplicação direta de uma camada de GELFOAM®, envolto por gaze petrolizada, para prevenção do sangramento da área cruenta do pedículo do retalho, acarretando melhor hemostasia e menos manipulação do pedículo vascular.
Interpolated flaps are among the most important and functional flaps in reconstructive plastic surgery, representing a safe option even in the most difficult cases. The pedicle of the interpolated flap requires a dressing to avoid bleeding and local contamination. This dressing often fails to prevent minor bleedings, which occurs within the first 24-48 hours. As a result, it needs to be continuously changed, from three to five times on average. The technique proposed in this study consists in a direct application of a GELFOAM® layer. This is subsequently wrapped with petroleum gauze to prevent bleeding of the open area in the pedicle flap, improving hemostasis and reducing the manipulation of the vascular pedicle.
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Humanos , Masculino , Femenino , Adulto , Persona de Mediana Edad , Anciano , Anciano de 80 o más Años , Historia del Siglo XXI , Complicaciones Posoperatorias , Colgajos Quirúrgicos , Terapéutica , Vendajes , Hemorragia Posoperatoria , Difusión de Innovaciones , Hemostasis , Hemostasis Quirúrgica , Complicaciones Posoperatorias/terapia , Colgajos Quirúrgicos/cirugía , Terapéutica/métodos , Vendajes/efectos adversos , Hemorragia Posoperatoria/cirugía , Hemorragia Posoperatoria/terapia , Hemostasis/efectos de los fármacos , Hemostasis Quirúrgica/métodosRESUMEN
BACKGROUND: Fracture of the clavicle is common, accounting for 2.6 to 4.0 % of all fractures, with an overall incidence of 36.5 to 64 per 100,000 per year. Around 80 % of clavicle fractures occur in the middle third of the clavicle. Randomised controlled trials comparing treatment interventions have failed to indicate the best therapeutic practices for these fractures. The objective of this study is to evaluate the effects (benefits and harms) of two commonly-used conservative interventions: the figure-of-eight bandage versus the arm sling as treatments of middle-third clavicle fractures. METHODS/DESIGN: This project has been designed as a single-centre, two-arm randomised controlled trial that will compare two interventions: figure-of-eight bandage versus the arm sling. We propose to recruit 110 adults, aged 18 years or older, with an acute (less than 10 days since injury) middle-third clavicle fracture. The primary outcomes to be evaluated will be function and/or disability measured by the Disability of the Arm, Shoulder, and Hand (DASH) questionnaire. In order to assess the secondary outcomes, the Modified University of California at Los Angeles (modified - UCLA) Shoulder Rating Scale will be used. The occurrence of pain (Visual Analogue Scale for pain (VAS)), treatment failure, adverse events and the ability to return to previous activities will also be recorded and evaluated as secondary outcomes. DATA ANALYSIS: the primary outcome DASH score and the secondary outcomes - modified UCLA and VAS scores - will be analysed graphically. We will apply generalised mixed models with the intervention groups (two levels), and time-point assessments (seven levels) as fixed effects and patients as a random effect. DISCUSSION: According to the current literature there is very limited evidence from two small trials regarding the effectiveness of different methods of conservative interventions for treating clavicle fractures. This is the first randomised controlled trial comparing the figure-of-eight bandage versus the arm sling for treating clavicle fractures that follows the CONSORT Statement guidelines. TRIAL REGISTRATION: ClinicalTrials.gov NCT02398006 .
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Vendajes , Clavícula/lesiones , Curación de Fractura , Fracturas Óseas/terapia , Procedimientos Ortopédicos/instrumentación , Adolescente , Adulto , Anciano , Vendajes/efectos adversos , Brasil , Clavícula/fisiopatología , Protocolos Clínicos , Evaluación de la Discapacidad , Femenino , Fracturas Óseas/diagnóstico , Fracturas Óseas/fisiopatología , Humanos , Masculino , Persona de Mediana Edad , Procedimientos Ortopédicos/efectos adversos , Dimensión del Dolor , Recuperación de la Función , Proyectos de Investigación , Encuestas y Cuestionarios , Factores de Tiempo , Resultado del Tratamiento , Adulto JovenRESUMEN
This work presents the development of a new bioactive material for wound therapeutics which may play a dual role of modulate metallo proteinases activity while prevents infection blocking out pathogenic microorganisms and foreign materials. A CGP/PVA film was activated by covalent immobilization of trypsin. Results from biocompatibility test revealed that PDL fibroblasts grown on the surface of CGP/PVA and the high amount of viable cells proved absence of cytotoxicity. Trypsin immobilized onto CGP/PVA film remained 100% active after 28 days stored dried at room temperature. In addition, CGP/PVA-trypsin film could be used for 9 cycles of storage/use without loss of activity. After immobilization, trypsin retained its collagenolytic activity, indicating this material as a promising material for wound dressing applications.
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Anacardium/química , Vendajes , Materiales Biocompatibles/farmacología , Gomas de Plantas/química , Polisacáridos/farmacología , Cicatrización de Heridas/efectos de los fármacos , Animales , Vendajes/efectos adversos , Materiales Biocompatibles/efectos adversos , Materiales Biocompatibles/química , Materiales Biocompatibles/aislamiento & purificación , Bovinos , Supervivencia Celular/efectos de los fármacos , Colágeno/metabolismo , Estabilidad de Enzimas , Enzimas Inmovilizadas/química , Enzimas Inmovilizadas/metabolismo , Humanos , Concentración de Iones de Hidrógeno , Hidrólisis , Modelos Moleculares , Oxidación-Reducción , Polisacáridos/efectos adversos , Polisacáridos/química , Polisacáridos/aislamiento & purificación , Alcohol Polivinílico/química , Conformación Proteica , Temperatura , Tripsina/química , Tripsina/metabolismoRESUMEN
INTRODUÇÃO: O objetivo deste estudo é relatar a nossa experiência com curativo de colágeno e alginato (Fibracol®) para cobrir áreas doadoras de enxerto de pele de espessura parcial. MÉTODO: Estudamos, retrospectivamente, 35 prontuários de pacientes que utilizaram o Fibracol® em áreas doadoras. Nossa rotina para cobrir a área doadora é a seguinte: cobertura da área com uma ou mais unidades de Fibracol® e, em seguida, com uma película à prova de água. Depois de três ou quatro dias, remover o curativo, limpar delicadamente com soro fisiológico e gaze e, quando julgava-se necessário, cobria-se novamente. A idade média foi de 25,52 anos (1-65). RESULTADOS: A coxa foi usada como área doadora em 29 pacientes, o braço em 2, a perna em 4 e tronco em 3 (2 pacientes tiveram mais de uma área doadora). O tempo médio necessário para epitelização foi de 4,51 dias (3-8). O valor de R do coeficiente de correlação de Pearson correlacionando a idade e tempo de epitelização foi -0,0755, com p = 0,6685. Nenhum dos pacientes teve infecção na área doadora. O curativo ideal para a área doadora do enxerto de pele de espessura parcial teria muitas características, incluindo: preço baixo, bom conforto do paciente, baixa taxa de infecção, período curto de tempo para epitelização, etc. CONCLUSÃO: Os autores relatam uma boa experiência usando Fibracol® em 35 pacientes, durante um período de 22 meses. O tempo para epitelização foi de 4,51 dias, mais curta do que a maioria dos trabalhos publicados, e não tinha correlação com a idade do paciente.
INTRODUCTION: The objective of this study was to report our findings with a collagen and alginate dressing (Fibracol®) used to cover donor areas of partial-thickness skin grafts. METHOD: We retrospectively evaluated the medical records of 35 patients in whom Fibracol® was used on donor areas. The routine used to manage the donor area is as follows: The area is covered with one or more units of Fibracol®, followed by application of a waterproof film. After three or four days, the dressing is removed and the area cleaned gently with saline and gauze; the area is dressed again if necessary. The mean patient age was 25.52 years (range, 1-65 years). RESULTS: The thigh was used as the donor area in 29 patients, the arm in 2, the leg in 4, and the trunk in 3. Two patients had more than one donor area. The mean time needed for epithelization was 4.51 days (range, 3-8 days). The Pearson correlation coefficient value correlating age and time of epithelization was -0.0755; p = 0.6685. None of the patients experienced an infection in the donor area. The ideal dressing for the donor area of split-thickness skin grafts would have multiple characteristics including low price, good patient comfort, low infection rate, and a short epithelization period. CONCLUSION: The authors report a positive experience with the use of Fibracol® in 35 patients over a period of 22 months. The mean epithelization period was 4.51 days, shorter than that in the majority of published studies, and had no correlation with the age of the patient.
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Humanos , Masculino , Femenino , Adulto , Persona de Mediana Edad , Historia del Siglo XXI , Vendajes , Quemaduras , Registros Médicos , Estudios Retrospectivos , Colágeno , Trasplante de Piel , Vendas Hidrocoloidales , Alginatos , Vendajes/efectos adversos , Vendajes/normas , Quemaduras/cirugía , Quemaduras/terapia , Registros Médicos/normas , Colágeno/uso terapéutico , Trasplante de Piel/métodos , Vendas Hidrocoloidales/efectos adversos , Vendas Hidrocoloidales/normas , Alginatos/uso terapéuticoRESUMEN
Introdução: O sucesso de um enxerto de pele é avaliado não apenas pela integração do enxerto em si, mas também pela qualidade da recuperação da área doadora. A despeito de as áreas doadoras de enxertos representarem o melhor local para estudo de cicatrização de feridas, regimes de tratamento, de áreas doadoras, tem sido incompletamente estudados. Objetivo: Avaliação da eficácia de espumas de poliuretano como curativo de áreas doadoras de enxertos. Método: Estudo prospectivo no qual áreas doadoras de enxertos foram tratadas com espumas de poliuretano como alternativa a filmes de acetato de celulose. Resultados: Foram tratados 11 pacientes e catorze áreas doadoras de enxerto. Aderência prolongada (73%) e odor desagradável (45%) foram os problemas encontrados. Os resultados foram considerados insatisfatórios na grande maioria dos casos (73%). Conclusões: O uso de espumas de poliuretano mostrou-se ineficaz, nesse grupo de pacientes, devido à ocorrência de alto índice de complicações.
Introduction: The success of a skin graft is evaluated by not only the integration of the graft itself, but also the quality of the recovery of the donor site. Despite the fact that graft donor sites represent the best place to study wound healing, treatment regimens for donor sites have not been studied extensively. Method: To evaluate the efficiency of polyurethane foam as a dressing for graft donor sites. Methods: We conducted a prospective study in which graft donor sites were treated with polyurethane foam dressing, as an alternative to a cellulose acetate film. Results: We treated 11 patients and 14 donor graft sites. Problems associated with the use of polyurethane foam included prolonged adherence (73%) and an unpleasant odor (45%). The majority of patients reported that they found the dressing to be unsatisfactory (73%). Conclusions: The use of a polyurethane foam was shown to be ineffective as a graft donor site dressing, due to the high rate of associated complications.
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Humanos , Masculino , Femenino , Adulto , Persona de Mediana Edad , Historia del Siglo XXI , Poliuretanos , Complicaciones Posoperatorias , Piel , Vendajes , Cicatrización de Heridas , Heridas y Lesiones , Apósitos Biológicos , Eficacia , Estudios Prospectivos , Trasplante de Piel , Estudio de Evaluación , Procedimientos Quirúrgicos Dermatologicos , Poliuretanos/análisis , Poliuretanos/uso terapéutico , Complicaciones Posoperatorias/cirugía , Piel/anatomía & histología , Vendajes/efectos adversos , Vendajes/normas , Heridas y Lesiones/cirugía , Heridas y Lesiones/terapia , Apósitos Biológicos/efectos adversos , Apósitos Biológicos/normas , Eficacia/métodos , Trasplante de Piel/efectos adversos , Trasplante de Piel/métodos , Trasplante de Piel/normas , Procedimientos Quirúrgicos Dermatologicos/efectos adversos , Procedimientos Quirúrgicos Dermatologicos/métodosRESUMEN
BACKGROUND: One of the major risk variables for surgical site infection is wound management. Understanding infection risk factors for breast operations is essential in order to develop infection-prevention strategies and improve surgical outcomes. The aim of this trial is to assess the influence of dressing wear time on surgical site infection rates and skin colonization. Patients' perception at self-assessment will also be analyzed. METHODS/DESIGN: This is a two-arm randomized controlled trial. Two hundred breast cancer patients undergoing immediate or delayed breast reconstruction will be prospectively enrolled. Patients will be randomly allocated to group I (dressing removed on postoperative day one) or group II (dressing removed on postoperative day six). Surgical site infections will be defined by standard criteria from the Centers for Disease Control and Prevention (CDC). Skin colonization will be assessed by culture of samples collected at predefined time points. Patients will score dressing wear time with regard to safety, comfort and convenience. DISCUSSION: The evidence to support dressing standards for breast surgery wounds is empiric and scarce. CDC recommends protecting, with a sterile dressing for 24 to 48 hours postoperatively, a primarily closed incision, but there is no recommendation to cover this kind of incision beyond 48 hours, or on the appropriate time to shower or bathe with an uncovered incision. The results of the ongoing trial may support standard recommendations regarding dressing wear time after breast reconstruction. TRIAL REGISTRATION: ClinicalTrials.gov identifier: http://NCT01148823.
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Vendajes , Neoplasias de la Mama/cirugía , Control de Infecciones/métodos , Mamoplastia , Proyectos de Investigación , Infección de la Herida Quirúrgica/prevención & control , Vendajes/efectos adversos , Brasil , Protocolos Clínicos , Femenino , Humanos , Mamoplastia/efectos adversos , Mastectomía , Satisfacción del Paciente , Estudios Prospectivos , Piel/microbiología , Infección de la Herida Quirúrgica/microbiología , Factores de Tiempo , Resultado del Tratamiento , Cicatrización de HeridasRESUMEN
BACKGROUND: The natural biomembrane of latex extracted from Hevea brasiliensis has been used as a dressing for skin ulcers. OBJECTIVES: To evaluate how safe the natural biomembrane is in relation to hypersensitivity to latex when used as a dressing. METHODS: We selected patients with skin ulcers, forming the following groups: control - low occupational exposure to latex (n = 17); latex-exposed control - high occupational exposure (n = 14); ulcerated, using the natural biomembrane (n = 13); ulcerated control, not using the natural biomembrane (n = 14); and new cases (n = 9), assessed before and after 3 months of using the natural biomembrane. All patients underwent clinical and epidemiological evaluation for latex hypersensitivity and specific IgE (UniCap(®)), and the control and latex-exposed control groups underwent the patch test. RESULTS: Hypersensitivity was positive in 64.7% of the patients in the control group, 71.4% of the patients in the latex-exposed control group, 61.5% of the ulcerated using the natural biomembrane, 35.7% of the ulcerated control, and only 22 , 2% of the new cases. In the patch test of the control and latex-exposed control groups, only one individual in the control group (low contact) showed erythema in the first reading, which became negative in the second. The mean contact with latex in the latex-exposed control group was 3.42 hours / day. In the fluoroimmunoenzymatic assay, most of the sera was classified as zero (range 0-6). No serum was rated above 2, which is not considered significant for hypersensitivity (classification > 4). CONCLUSION: The natural biomembrane proved to be safe as a dressing, for it did not induce hypersensitivity reactions among the volunteers who underwent the patch test or among users of the natural biomembrane, as it was clinically and immunologically demonstrated by IgE levels.
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Vendajes/efectos adversos , Materiales Biocompatibles/uso terapéutico , Hevea , Hipersensibilidad al Látex/diagnóstico , Úlcera de la Pierna/terapia , Adulto , Materiales Biocompatibles/efectos adversos , Estudios de Casos y Controles , Reacciones Cruzadas , Femenino , Humanos , Látex/inmunología , Masculino , Persona de Mediana Edad , Pruebas del Parche , Adulto JovenRESUMEN
FUNDAMENTOS: A biomembrana vegetal do látex da seringueira Hevea brasiliensis tem sido usada como curativo para úlceras cutâneas. OBJETIVOS: Avaliar a segurança da biomembrana vegetal como curativo em relação à hipersensibilidade ao látex. MÉTODOS: Foram selecionados pacientes com úlceras cutâneas constituindo-se os grupos: controle - baixa exposição profissional ao látex (n=17); alta exposição profissional (n=14); ulcerados em uso da biomembrana vegetal (n=13); ulcerados-controle sem uso da biomembrana vegetal (n=14) e casos novos (n=9), submetidos à avaliação pré e após 3 meses de uso da biomembrana vegetal. Todos foram submetidos à avaliação clínico-epidemiológica quanto à hipersensibilidade ao látex e IgE específica (UniCap®), e os grupos controle e controle exposto ao látex ao "patch test". RESULTADOS: A história de hipersensibilidade foi positiva em 64,7 por cento dos pacientes do grupo-controle, 71,4 por cento do controle exposto ao látex, 61,5 por cento dos ulcerados em uso da biomembrana vegetal, 35,7 por cento dos ulcerados-controle, e apenas 22,2 por cento no grupo casos novos. Ao teste de contato dos grupos controle e controle exposto ao látex, apenas um indivíduo do grupo C (baixo contato) apresentou eritema na primeira leitura, negativando-se na segunda. A média de contato com látex no grupo-controle exposto ao látex foi de 3,42 horas/dia. No ensaio fluoroimunoenzimático, a grande maioria dos soros foi classificada como zero (variação 0 a 6). Nenhum soro recebeu classificação acima de 2, não sendo considerada classificação significante para hipersensibilidade (classificação > 4). CONCLUSÃO: A biomembrana vegetal mostrou-se segura como curativo, pois não induziu reações de hipersensibilidade entre os voluntários submetidos ao "patch test", nem entre os usuários da biomembrana vegetal, como demonstrado clinica e imunologicamente pela dosagem de IgE.
BACKGROUND: The natural biomembrane of latex extracted from Hevea brasiliensis has been used as a dressing for skin ulcers. OBJECTIVES: To evaluate how safe the natural biomembrane is in relation to hypersensitivity to latex when used as a dressing. METHODS: We selected patients with skin ulcers, forming the following groups: control - low occupational exposure to latex (n = 17); latex-exposed control - high occupational exposure (n = 14); ulcerated, using the natural biomembrane (n = 13); ulcerated control, not using the natural biomembrane (n = 14); and new cases (n = 9), assessed before and after 3 months of using the natural biomembrane. All patients underwent clinical and epidemiological evaluation for latex hypersensitivity and specific IgE (UniCap®), and the control and latex-exposed control groups underwent the patch test. RESULTS: Hypersensitivity was positive in 64.7 percent of the patients in the control group, 71.4 percent of the patients in the latex-exposed control group, 61.5 percent of the ulcerated using the natural biomembrane, 35.7 percent of the ulcerated control, and only 22 , 2 percent of the new cases. In the patch test of the control and latex-exposed control groups, only one individual in the control group (low contact) showed erythema in the first reading, which became negative in the second. The mean contact with latex in the latex-exposed control group was 3.42 hours / day. In the fluoroimmunoenzymatic assay, most of the sera was classified as zero (range 0-6). No serum was rated above 2, which is not considered significant for hypersensitivity (classification > 4). CONCLUSION: The natural biomembrane proved to be safe as a dressing, for it did not induce hypersensitivity reactions among the volunteers who underwent the patch test or among users of the natural biomembrane, as it was clinically and immunologically demonstrated by IgE levels.
Asunto(s)
Adulto , Femenino , Humanos , Masculino , Persona de Mediana Edad , Adulto Joven , Vendajes/efectos adversos , Materiales Biocompatibles/uso terapéutico , Hevea , Hipersensibilidad al Látex/diagnóstico , Úlcera de la Pierna/terapia , Materiales Biocompatibles/efectos adversos , Estudios de Casos y Controles , Reacciones Cruzadas , Látex/inmunología , Pruebas del ParcheRESUMEN
Hidrogéis compreendem uma importante classe de materiais poliméricos adequados à aplicação como curativos de feridas e queimaduras. A estrutura tridimensional hidrofílica dos hidrogéis permite que estes mantenham a umidade ideal no leito das feridas, absorvam o exsudato e não causem danos ao novo tecido durante as trocas dos curativos. No caso dos hidrogéis, essas trocas podem ser menos frequentes. Além disso, curativos que auxiliem na remoção de tecidos necrosados e ainda sejam capazes de oferecer tratamentos extras que acelerem o processo de cicatrização são desejáveis. Este trabalho apresenta a produção de materiais à base de hidrogel capazes de auxiliar neste processo de diferentes maneiras. Primeiramente, são apresentados hidrogéis formados a partir de nanofibras de poli(N-vinil-2-pirrolidona) (PVP) produzidas por eletrofiação, seguido da reticulação através da utilização de radiação UV-C ou reação de Fenton. A utilização da eletrofiação como técnica auxiliar na formação dos hidrogéis permitiu o controle da porosidade através da formação de fibras de diferentes diâmetros. A evidência de tal propriedade foi constatada através da produção de materiais que apresentam diferentes perfis de liberação da proteína modelo albumina de soro bovino (BSA). O hidrogel de PVP nanoestruturado foi capaz de liberar e manter a atividade da colagenase, uma importante enzima aplicada no tratamento de feridas via desbridamento enzimático, durante as 48 horas em que foi avaliado. Além disso, hidrogéis bactericidas nanoestruturados foram produzidos a partir de nanocompósitos de PVP e nanopartículas de prata (AgNP) produzidos por eletrofiação. Esses hidrogéis apresentaram propriedades térmicas semelhantes aos hidrogéis sem AgNP, diminuindo, contudo, a sua capacidade de intumescimento. Esses hidrogéis mostraram-se ativos contra bactérias gram-positivas e gram-negativas a partir de 100 ppm de AgNPs. Adicionalmente, foi estudada a formação de um hidrogel modelo composto PVP/AgNP/Imidazol, almejando-se a produção de um material bactericida-fungicida a base de hidrogel. Este hidrogel apresentou atividade conta três espécies de Candida a partir de 500 ppm de imidazol no material. Embora exista a formação de um complexo estável entre AgNP e Imidazol, cálculos teóricos e a constatação da atividade fungicida corroboram com o fato de que derivados imidazólicos podem ser liberados a partir deste hidrogel híbrido. A produção de hidrogéis físicos compostos por blendas de PVP/Polianidridos sintetizados a partir de derivados de hidroxicinamatos e ácido salicílico, capazes de liberar moléculas de interesse biológico quando parcialmente degradados hidroliticamente, também é descrita neste trabalho. Os resultados indicam que interações hidrofóbicas entre a PVP e os polianidridos sintetizados podem ser responsáveis pela formação dos hidrogéis físicos e pela miscibilidade das blendas produzidas. Os hidrogéis físicos de PVP/Polianidridos foram obtidos na forma de filmes por evaporação do solvente. Micro- e nanofibras também foram obtidas por eletrofiação. Desta maneira, o presente trabalho contribui com o desenvolvimento de uma geração de curativos multifuncionais aplicados no tratamento de feridas crônicas e queimaduras
Hydrogels comprise an important class of polymeric materials that finds application as wound and burn dressings. The hydrophilic three-dimensional structure of hydrogels helps to provide the ideal humidity at the wound bed, to remove exsudates and to prevent damages to the new tissue during dressing substitution. Furthermore, these wound dressings are able to remove necrotic tissues and, therefore, capable to offer extra treatments that would benefit the healing processes. This work describes the production of hydrogel based materials that are able to act in wound healing by different ways. First, it is presented hydrogels composed of poly(N-vinyl-2-pyrrolidone) (PVP) nanofibers produced by electrospinning, followed by its crosslinking using UV-C radiation or Fenton reaction. The use of electrospinning in the hydrogel formation allowed porosity control by obtaining fibers of different diameters. This was evidenced by achieving materials that present different release profiles of the model protein bovine serum albumin (BSA). The nanostructured PVP hydrogel was capable of releasing and maintaining collagenase activity during 48 hour of evaluation. This is an important enzyme that find application in wound healing based on enzymatic debridement. Moreover, nanostructured bactericidal hydrogels were produced from PVP and silver nanoparticles (AgNP) composite through electrospinning, resulting in hydrogels with thermal properties similar to those hydrogels without AgNP, decreasing its swelling ability. These hydrogels were active against gram-positives and gram-negatives bacteria starting from 100 ppm of AgNP. In addition, the production of a model hydrogel composed by PVP/AgNP/Imidazole was investigated, aiming at a bactericidal-fungicidal hydrogel based material. This hydrogel was active against three Candida having 500 ppm of imidazole into the structure. In spite of the formation of a stable complex between AgNP and imidazole, theoretic calculations and the observed fungicidal activity corroborate with the fact that imidazoles derivatives can be released from this hybrid hydrogel. Physical hydrogels composed of PVP/Polyanhydrides blends were synthesized from hydroxycinammates derivatives and salicylic acid. These materials which were capable of releasing molecules with biological potential upon hydrolysis, are also described in this work. The results indicate that hydrophobic interactions between PVP and the synthesized polyanhydrides could be responsible for the hydrogel formation and blend miscibility as well. PVP/Polyanhydride physical hydrogels were obtained from cast films. Micro- and nanofibers were also obtained by electrospinning. Thus, the present work contributes with the development of the new generation of smart dressings for wound and burn healing
Asunto(s)
Polianhídridos/análisis , Vendas Hidrocoloidales/estadística & datos numéricos , Vendajes/efectos adversos , Hidrogeles/análisis , Nanopartículas/estadística & datos numéricos , Nanotecnología/métodos , Povidona/efectos adversosRESUMEN
The purpose of the present study was to ascertain whether artificial skull deformation, carried out during infancy, has an effect on the pneumatization of the frontal and maxillary sinuses and on the osseous structure of the frontal bone. Thus, two normal and 12 artificially deformed adult human skulls (12 males, two females) from the collection of pre-Columbian Peruvian skeletons and mummies in the Institute of Anthropology and Human Genetics (University of Munich) were investigated by computed tomography. These skulls had been excavated from four sites on the Peruvian coast: Las Trancas, Cahuachi. Pacatnamu, and Estaqueria. The volumes of the maxillary sinuses varied from 5.18 mL to 17.19 mL. Those of the frontal sinuses varied from zero to 6.21 mL. The artificial deformation of the skull, which occurred during infancy, had no influence on the size of the maxillary and frontal sinuses. There was also no difference in the average bone thickness of the os frontale; however, artificial deformation in infancy had an influence on the bone structure, resulting in a tremendous rarefication of the diploe of the frontal bones. Based on these findings we conclude that the various types of skull deformation instituted in infancy seem to exert no inhibitory effect on the pneumatization of either the frontal or maxillary sinuses.
Asunto(s)
Vendajes/efectos adversos , Discapacidades del Desarrollo/diagnóstico por imagen , Discapacidades del Desarrollo/etiología , Hueso Frontal/diagnóstico por imagen , Momias/diagnóstico por imagen , Senos Paranasales/diagnóstico por imagen , Enfermedades Óseas/diagnóstico por imagen , Enfermedades Óseas/etiología , Femenino , Humanos , Masculino , Enfermedades de los Senos Paranasales/diagnóstico por imagen , Enfermedades de los Senos Paranasales/etiología , Perú , RadiografíaAsunto(s)
Humanos , Traumatismos Abdominales/cirugía , Vendajes/estadística & datos numéricos , Procedimientos Quirúrgicos Operativos , Absceso Abdominal/etiología , Vendajes/efectos adversos , Hemorragia/etiología , Hemorragia/terapia , Hígado/lesiones , Factores de Riesgo , Síndromes Compartimentales/etiologíaRESUMEN
A case of iodoform toxicity caused by use of 5% iodoformed bandage in occlusive surgical dressings for tamponing of diffuse hemorrhage in pelvic cavity, following amputation for treatment of rectum adenocarcinoma. Despite the frequent use of iodoformed dressings following surgical procedures, the signs and symptoms of iodoform toxicity syndrome can be easily mistook for other syndromes. A revision of the published observations suggest that this syndrome is not as rare as thought but probably has been underdiagnosed.
Asunto(s)
Vendajes/efectos adversos , Hidrocarburos Yodados/envenenamiento , Anciano , Estudios de Seguimiento , Humanos , Masculino , Periodo PosoperatorioRESUMEN
Three children with the rare occurrence of zygomycosis are descibed: two had involvement of a solitary lesion of gangrenous cellulitis on the buttocks, and th third was a neonate with gastric performation and a gangrenous appendicitis. All three patients were compromised hosts (two with leukemia and one a premature infant with respiratory distress syndrome). All three patients appeared to have acquired the same organism. Rhizopus oryzae, from the same fomites, elastic bondages (Elastoplast). The Center for Disease Control has received several other reports of zygomycosis traceable to the same material. Alll three of our patients were cured of their infections. Early diagnosis and a combined surgical and chemotherapeutic approach appear to prevent death from zygomycosis.
Asunto(s)
Mucormicosis/etiología , Anfotericina B/uso terapéutico , Apendicitis/etiología , Vendajes/efectos adversos , Celulitis (Flemón)/etiología , Niño , Femenino , Humanos , Recién Nacido , Leucemia Linfoide/complicaciones , Masculino , Mucormicosis/complicaciones , Mucormicosis/transmisión , Úlcera Péptica Perforada/complicaciones , Síndrome de Dificultad Respiratoria del Recién Nacido/complicaciones , Rhizopus/aislamiento & purificación , Úlcera Gástrica/complicacionesRESUMEN
Strips of gauze and furacin gauze were implanted into the subcutaneous space and employed as dressing of dorsal incisions of albino rats. The animals were sacrificed after 24 hours, 2, 5, and 7 post-operative days. The pieces were processed for histological examination. It is possible to conclude that the furacin gauze provokes more severe inflammatory reactions and does not favour the connective neoformation and the epithelization. The furacin gauze should be utilized only as germicide aim.