RESUMEN
Reported are the results obtained with different immunization schedules on adjuvant or freeze-dried concentrated (FDC) primary hamster kidney cell (PHKC) rabies vaccine on volunteers. The FDC vaccine (potency, 4.5 IU), which was inoculated in six doses, on days 0, 3, 7, 14, 30 and 90 and the adjuvant vaccine (potency 2.5 IU), which was inoculated in five doses, on days 0 to 7 (double dose), 14, 30 and 90, induced earlier, higher, and more persistent neutralizing antibody titres than the adjuvant vaccine which was inoculated in five doses on days 0, 3, 7, 14, 30. The persistance of the neutralizing antibody titres induced by three intradermal doses of vaccine administered on days 0 (4 sites), 7 (2 sites), and 28 (1 site) was lower than that induced by six intramuscular doses administered on days 0, 3, 7, 14, 30 and 90
A cell-mediated immunity (CMI) was also induced in vaccinees who received the adjuvant vaccine. The protective effect of the adjuvant vaccine was better than that of the previously used Semple vaccine and has had a positive effect on the epidemiology of human rabies in China
Asunto(s)
Rabia/prevención & control , Vacunas Antirrábicas/terapia , Pruebas de Neutralización , Liofilización , Vacunas Antirrábicas/aislamiento & purificación , Línea Celular , Inmunidad Celular , Riñón/citología , Virus de la Rabia/inmunología , Formación de Anticuerpos , ChinaRESUMEN
Four comparable groups were constituted, of 14 bovines each. One was kept as a control group and the others were inoculated with Formidogel, Flury and modified Fuenzalida anti-rabies vaccines, respectively
After eight months, all the animals in the experiment were submitted to the "challenge", with the following results in mortality rates: control group, 12/13 (92.3 per cent); group inoculated with the Fuenzalida vaccine, 13/14 (92.9 per cent); group inoculated with the Flury vaccine, 6/13 (46.2 per cent); group inoculated with the Formidogel vaccine, 3/13 (23.1 per cent). According to this experiment, the Fuenzalida vaccine did not give satisfactory results with bovines; account must be taken of the modification introduced in its preparation
A statistical analysis of the results revealed that, at the 5 per cent rejection level adopted:
1) the mortality rate for the group inoculated with the Formidogel vaccine did not differ significantly from that of the group receiving the Flury vaccine;
2) the mortality rate for the group that received the Formidogel vaccine and for the group inoculated with the Flury vaccine was significantly lower than either that of the group inoculated with the modified Fuenzalida vaccine or that of the control group;
3) the mortality rate observed in the group inoculated with the modified Fuenzalida vaccine did not differ significantly from that of the group ...(AU)
Asunto(s)
Vacunas Antirrábicas/inmunología , Vacunas Antirrábicas/terapia , Rabia/inmunología , Enfermedades de los Bovinos , BrasilRESUMEN
Currently available antirabies vaccines prepared from either animal brains or embryonated eggs have the unavoidable disadvantage of products prepared in vivo; the bulk of antigenic material in the vaccine is not viral but cellular. The hazards associated with the use of such material are well known
Combined use of antiserum and vaccine as recommended by the WHO Expert Committee on Rabies has greatly reduced the mortality rate for persons severely exposed to bites by wild animansl, but at the cost of the added risk of postvaccinal reactions from administration of heterologous serum
Development of a tissue culture source of virus for vaccine production appears to be the most promising possibility for greater progress toward rabies control
Antirabies vaccine prepared with a human diploid cell strain (WI-38) has proved a very potent antigen when tested in monkeys
Attenuated live virus (Flury HEP) vaccine and beta-propiolactone inactivated vaccine prepared with the Pitman-Moore strain of rabies virus (both of tissue culture origin) have been compared with the conventional type of vaccine by serum neutralization tests and animal resistance to challenge with standard strain of rabies virus; Rhesus and African green monkeys have been used as test animals
Tissue culture vaccine administered in one or three doses has induced an earlier appearance of antibodies at a much higher titer, and has ...(AU
Asunto(s)
Vacunas Antirrábicas/efectos adversos , Vacunas Antirrábicas/terapia , Virus de la Rabia/inmunologíaRESUMEN
The rabies campaign on the northern border of Mexico is being conducted in accordance with established procedures. These activities will be reinforced by the work done in laboratories with fluorescent microscopy and by the establishment of observation kennels. Greater attention was paid to such basic program activities as the vaccination and destruction of dogs, the observation of suspect animals, laboratory tests, vaccination of bitten persons, and so forth. The bi-national committees must operate, but they must work with true enthusiasm if their work is to be effective. Programs make more progress when there are frequent exchanges of ideas and steps are taken to implement every detail of the rabies campaign